2-Bromo-4-fluorobenzonitrile
- Product Name
- 2-Bromo-4-fluorobenzonitrile
- CAS No.
- 36282-26-5
- Chemical Name
- 2-Bromo-4-fluorobenzonitrile
- Synonyms
- Bromo-4-fluorobenzonitrile;2-BROMO-4-FLUOROBENZONITRILE;Benzonitrile, 2-broMo-4-fluoro-;2-Bromo-4-fluorobenzonitrile98%;2-Bromo-4-fluorobenzonitrile >2-Bromo-4-fluorobenzonitrile 98%
- CBNumber
- CB9732074
- Molecular Formula
- C7H3BrFN
- Formula Weight
- 200.01
- MOL File
- 36282-26-5.mol
2-Bromo-4-fluorobenzonitrile Property
- Melting point:
- 77-78°C
- Boiling point:
- 262.4±25.0 °C(Predicted)
- Density
- 1.69±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Gray to Brown
- BRN
- 1940597
- InChI
- InChI=1S/C7H3BrFN/c8-7-3-6(9)2-1-5(7)4-10/h1-3H
- InChIKey
- MNNDREXLRLDWEY-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC=C(F)C=C1Br
- CAS DataBase Reference
- 36282-26-5(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xi,Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 22-36/37/39-36/37-26-9
- RIDADR
- 3439
- WGK Germany
- 3
- Hazard Note
- Toxic
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29269090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 736031
- Product name
- 2-Bromo-4-fluorobenzonitrile
- Purity
- 97%
- Packaging
- 25g
- Price
- $165
- Updated
- 2023/06/20
- Product number
- B2744
- Product name
- 2-Bromo-4-fluorobenzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $28
- Updated
- 2025/07/31
- Product number
- B2744
- Product name
- 2-Bromo-4-fluorobenzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $76
- Updated
- 2025/07/31
- Product number
- B692018
- Product name
- 2-Bromo-4-fluorobenzonitrile
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 009433
- Product name
- 2-Bromo-4-fluorobenzonitrile
- Purity
- 98%
- Packaging
- 5g
- Price
- $10
- Updated
- 2021/12/16
2-Bromo-4-fluorobenzonitrile Chemical Properties,Usage,Production
Chemical Properties
Off-white to light yellow powder
Synthesis
59142-68-6
36282-26-5
General procedure for the synthesis of 2-bromo-4-fluorobenzonitrile from 2-bromo-4-fluorobenzaldehyde: In a dry 2 mL reaction vial, 2-bromo-4-fluorobenzaldehyde (3a, 0.136 g, 1 mmol, 1 eq.) and pyridine (0.474 g, 6.0 mmol, 6 eq.) were added followed by the addition of acetonitrile (2 mL) to make the concentration of 3a to be 0.5 M. Next, to the reaction vial was added Ru(bpy)3(PF6)2 (0.017 g, 0.02 mmol, 0.02 eq.), 2 (0.043 g, 0.20 mmol, 0.20 eq.), (NH4)2S2O8 (0.501 g, 2.2 mmol, 2.2 eq.), and activated 3?molecular sieves (~0.2 g). The reaction vial was sealed and placed in a blue LED reactor for 24 hours of irradiation. The temperature of the mixture was maintained at ~50 °C during the reaction without fan cooling. Upon completion of irradiation, the reaction was quenched with EtOAc and the mixture was transferred to a dispensing funnel. Additional EtOAc (30 mL) and 0.5 M HCl (aq, 30 mL) were added to separate the organic and aqueous layers. The aqueous layer was extracted with EtOAc (3 × 20 mL), and the combined organic layers were washed sequentially with 0.5 M HCl (aq, 2 × 20 mL), saturated aqueous NaHCO3 (2 × 20 mL), and brine (20 mL). The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to obtain the crude product. The crude product was adsorbed on silica gel (the amount of silica gel was 1.5 times the weight of the theoretical product) and gently loaded onto a silica gel column. The target product was first rinsed with excess hexane (about 5 times the volume of the column), and then eluted with a hexane/EtOAc solvent mixture (3-4 times the volume of the column) with a volume ratio of 90:10. The eluate was concentrated by rotary evaporation to give pure 2-bromo-4-fluorobenzonitrile (3c, 0.066 g, 50% yield) as a white solid.
References
[1] Synlett, 2018, vol. 29, # 16, p. 2185 - 2190
[2] Organic and Biomolecular Chemistry, 2018, vol. 16, # 42, p. 7959 - 7963
2-Bromo-4-fluorobenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-4-fluorobenzonitrile manufacturers
- Product
- 2-Bromo-4-fluorobenzonitrile 36282-26-5
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 98%min
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20