ChemicalBook > CAS DataBase List > NAPHTHOL AS-E PHOSPHATE
NAPHTHOL AS-E PHOSPHATE
- Product Name
- NAPHTHOL AS-E PHOSPHATE
- CAS No.
- 18228-17-6
- Chemical Name
- NAPHTHOL AS-E PHOSPHATE
- Synonyms
- kg-501;NASEP;KD-501;NAPHTHOL AS-E PHOSPHATE;2-naphthol-AS-E-phosphate;KG-501(NaphtholAS-Ephosphate);KG-501 (2-naphthol-AS-E-phosphate);NAPHTHOL AS-E PHOSPHATE NAPHTHOL FREE;NAPHTHOL AS-E-PHOSPHATE, FOR HISTOLOGY;2-NAPHTHOL-AS-E-PHOSPHATE;NAPHTHOL AS-E PHOSPHATE
- CBNumber
- CB9737978
- Molecular Formula
- C17H13ClNO5P
- Formula Weight
- 377.72
- MOL File
- 18228-17-6.mol
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NAPHTHOL AS-E PHOSPHATE Property
- Density
- 1.567±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO: soluble
- form
- A crystalline solid
- pka
- 1.04±0.30(Predicted)
- color
- White to light yellow
- BRN
- 6664478
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Safety
- WGK Germany
- 3
- F
- 8-10-21
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 70485
- Product name
- Naphthol AS-E phosphate
- Purity
- for histology
- Packaging
- 250mg
- Price
- $105
- Updated
- 2024/03/01
TRC
- Product number
- N368028
- Product name
- Naphthol AS-E phosphate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- EN69791
- Product name
- Naphthol AS-E phosphate - 60%
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0027313
- Product name
- KG-501
- Purity
- 98.08%
- Packaging
- 5mg
- Price
- $50
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0027313
- Product name
- KG-501
- Purity
- 98.08%
- Packaging
- 10mg
- Price
- $70
- Updated
- 2021/12/16
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NAPHTHOL AS-E PHOSPHATE Chemical Properties,Usage,Production
Biological Activity
Naphthol AS-E phosphate is a CREB inhibitor that disrupts CREB-dependent transcription (Ki=10 μM) and CREB:CBP interaction (Ki=50 μM). It also disrupts the binding of phosphorylated CREB (Ser-133) to KIX with a Ki of approximately 90 μM.
in vitro
Naphthol AS-E phosphate inhibited (or partially inhibited) the induction of cAMP-related genes by preventing CREB:CBP interaction. KG-501 inhibited neurite outgrowth, synaptogenesis and reduced MAP2+ neurons.
in vivo
Naphthol AS-E phosphate inhibited the expression of CREB, CCL2 and ERK phosphorylation, while significantly reducing cAMP levels. CREB may help to fight neuroinflammation through the cAMP/ERKadjustment pathway, thereby protecting nerves.It significantly promoted neurological function in a mouse model treated with azomethane oxide (AOM), reducing ERK phosphorylation levels and cAMP concentrations in the cortex.
target
| Target | Value |
| CREB () |