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4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE

Product Name
4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE
CAS No.
26475-62-7
Chemical Name
4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE
Synonyms
EOS-60875;1-DIOXIDE-4-THIOMORPHOLINEETHANOL;1-DIXOIDE-4-THIOMORPHOLINEETHANOL;4-THIOMORPHOLINEETHANOL-1-DIOXIDE;2-(1,1-DIOXOTHIOMORPHOLINO)ETHANOL;4-Thiomorpholineethanol, 1,1-dioxide;2-(1,1-DIOXO-1,4-THIAZINAN-4-YL)ETHANOL;2-(1,1-dioxidothiomorpholin-4-yl)ethanol;4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE;N-(2-HYDROXYETHYL) THIOMORPHOLINE 1,1-DIOXIDE
CBNumber
CB9752515
Molecular Formula
C6H13NO3S
Formula Weight
179.24
MOL File
26475-62-7.mol
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4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE Property

Melting point:
74 °C
Boiling point:
197 °C / 1mmHg
Density 
1.287±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
soluble in Methanol
form 
powder to crystal
pka
14.80±0.10(Predicted)
color 
White to Light yellow to Light orange
InChI
InChI=1S/C6H13NO3S/c8-4-1-7-2-5-11(9,10)6-3-7/h8H,1-6H2
InChIKey
GILLKIJFJOBJCD-UHFFFAOYSA-N
SMILES
N1(CCO)CCS(=O)(=O)CC1
CAS DataBase Reference
26475-62-7(CAS DataBase Reference)
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
H1140
Product name
4-(2-Hydroxyethyl)thiomorpholine 1,1-Dioxide
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$100
Updated
2025/07/31
TCI Chemical
Product number
H1140
Product name
4-(2-Hydroxyethyl)thiomorpholine 1,1-Dioxide
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$296
Updated
2025/07/31
TRC
Product number
H998233
Product name
4-(2-Hydroxyethyl)thiomorpholine 1,1-Dioxide
Packaging
100mg
Price
$60
Updated
2021/12/16
Ark Pharm
Product number
P000476283
Product name
4-(2-Hydroxyethyl)thiomorpholine 1,1-Dioxide
Purity
95+%
Packaging
250mg
Price
$15
Updated
2021/12/16
Ark Pharm
Product number
P000476283
Product name
4-(2-Hydroxyethyl)thiomorpholine 1,1-Dioxide
Purity
95+%
Packaging
1g
Price
$38
Updated
2021/12/16
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4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE Chemical Properties,Usage,Production

Synthesis

39093-93-1

540-51-2

26475-62-7

To a stirred solution of 2-bromoethanol (11.78 mL, 165.92 mmol, 7.0 equiv) in acetonitrile (68 mL) was added potassium carbonate (9.8 g, 71.10 mmol, 3.0 equiv). The reaction mixture was stirred at room temperature for 30 minutes before thiomorpholine-1,1 -dioxide (3.2 g, 23.70 mmol, 1.0 eq.) was added. The reaction mixture was heated to reflux and stirred overnight. The progress of the reaction was monitored by thin layer chromatography (TLC) to confirm that the feedstock was completely consumed and the target product was generated. Upon completion of the reaction, the mixture was cooled to room temperature and filtered. The filtrate was concentrated to obtain the crude product, which was subsequently purified by column chromatography using a mixture of dichloromethane and 3% methanol as eluent, resulting in 4-(2-hydroxyethyl)thiomorpholine-1,1-dioxide (2.5 g, 60.0% yield) as a brown liquid. The product was characterized by 1H NMR (DMSO-d6, 300 MHz): δ 4.50 (t, 1H), 3.51 (q, 2H), 3.07 (m, 4H), 2.95 (m, 4H), 2.58 (t, 2H); Mass Spectrometry (MS): [M + H]+ m/z 180.19 (10%).

References

[1] Patent: WO2017/149518, 2017, A1. Location in patent: Page/Page column 24; 25

4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE Suppliers

Americas 1 China 71 Europe 1 India 2 Japan 1 United Kingdom 5 United States 12 Global 93
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006356688 18621169109
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86-21-61259102
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market03@meryer.com
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China
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
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021-67121385
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Sales-CN@TCIchemicals.com
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China
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Energy Chemical
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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Tongchuang Pharma(Suzhou). Co., Ltd.
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China
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+32 (0)37350701
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sales@tcieurope.eu
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Europe
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TCI AMERICA
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800-4238616
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+1-888-520-1075 / +1-503-283-1987
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sales@tciamerica.com
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9ding chemical ( Shanghai) Limited
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4009209199
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86-021-52271987
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sales@9dingchem.com
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China
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View Lastest Price from 4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
4-(2-Hydroxyethyl)thiomorpholine-1,1-dioxide 26475-62-7
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-26
Career Henan Chemical Co
Product
4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE 26475-62-7
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10 Tons
Release date
2020-02-19

26475-62-7, 4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDERelated Search:

4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE Thiomorpholine Thiomorpholine-1,1-dioxide 2-(1,1-DIOXO-1LAMBDA6,4-THIAZINAN-4-YL)-3-PHENYLPROPANOIC ACID (1,1-DIOXOTHIOMORPHOLINO)ACETIC ACID MONOHYDRATE ETHYL 2-(1,1-DIOXO-1LAMBDA6,4-THIAZINAN-4-YL)ACETATE 2-(1,1-DIOXO-1LAMBDA6,4-THIAZINAN-4-YL)-2-PHENYLACETIC ACID 2-(1,1-DIOXO-1LAMBDA6,4-THIAZINAN-4-YL)-3-METHYLBUTANOIC ACID 2-(1,1-DIOXIDOTHIOMORPHOLIN-4-YL)PROPANOIC ACID METHYL 3-CYCLOHEXYL-2-(1,1-DIOXO-1LAMBDA6,4-THIAZINAN-4-YL)PROPANOATE METHYL 2-(1,1-DIOXO-1LAMBDA6,4-THIAZINAN-4-YL)-3-PHENYLPROPANOATE 3-CYCLOHEXYL-2-(1,1-DIOXO-1LAMBDA6,4-THIAZINAN-4-YL)PROPANOIC ACID 4-(2-HYDROXY-1-PHENYLETHYL)-1LAMBDA6,4-THIAZINANE-1,1-DIONE 2-(1,1-DIOXO-1LAMBDA6,4-THIAZINAN-4-YL)-2-PHENYLETHYL 3,4-DICHLOROBENZENECARBOXYLATE 2-(1,1-DIOXO-1LAMBDA6,4-THIAZINAN-4-YL)-3,3-DIMETHYLBUTANOIC ACID 4-(2-BENZYLOXY-PROPYL)-THIOMORHOLINE 1,1-DIOXIDE 2-(1,1-DIOXO-1LAMBDA6,4-THIAZINAN-4-YL)-3-(1H-INDOL-3-YL)PROPANOIC ACID 4-(2-HYDROXY-1-METHYLETHYL)-1LAMBDA6,4-THIAZINANE-1,1-DIONE

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