Thiomorpholine-1,1-dioxide
- Product Name
- Thiomorpholine-1,1-dioxide
- CAS No.
- 39093-93-1
- Chemical Name
- Thiomorpholine-1,1-dioxide
- Synonyms
- THIOMORPHOLINE 1,1-DIOXIDE;1,1-DIOXOTHIOMORPHOLINE;DK771;DKSI157;EOS-62289;TIMTEC-BB SBB010267;THIOMORPHOLINE DIOXIDE;Thiomorpholine-1,1-oxide;1,1-DioxidothioMorpholine;ThioMorpholine-1,1-dioxid
- CBNumber
- CB7140484
- Molecular Formula
- C4H9NO2S
- Formula Weight
- 135.18
- MOL File
- 39093-93-1.mol
Thiomorpholine-1,1-dioxide Property
- Melting point:
- 0°C
- Boiling point:
- 0°C
- Density
- 1.239±0.06 g/cm3(Predicted)
- Flash point:
- 0°C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 6.48±0.20(Predicted)
- color
- White to Off-White
- InChI
- InChI=1S/C4H9NO2S/c6-8(7)3-1-5-2-4-8/h5H,1-4H2
- InChIKey
- NDOVLWQBFFJETK-UHFFFAOYSA-N
- SMILES
- N1CCS(=O)(=O)CC1
- CAS DataBase Reference
- 39093-93-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- T2193
- Product name
- Thiomorpholine 1,1-Dioxide
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $170
- Updated
- 2025/07/31
- Product number
- T2193
- Product name
- Thiomorpholine 1,1-Dioxide
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $523
- Updated
- 2025/07/31
- Product number
- T344568
- Product name
- Thiomorpholine 1,1-Dioxide
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 291067
- Product name
- Thiomorpholine 1,1-Dioxide
- Packaging
- 1g
- Price
- $396
- Updated
- 2021/12/16
- Product number
- T344568
- Product name
- Thiomorpholine 1,1-Dioxide
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
Thiomorpholine-1,1-dioxide Chemical Properties,Usage,Production
Chemical Properties
light yellow solid
Uses
Thiomorpholine 1,1-Dioxide is a useful building block, used in the synthetic preparation of antibacterial biaryloxazolidinone analogues, and isothiazolo-pyridine derivatives for use as cyclin G-associated kinase inhibitors and antiviral agents.
Synthesis
To a solution of tert-butylthiomorpholine-4-carboxylate (5.8 g, 0.024 mol) in dichloromethane (50 ml) was added trifluoroacetic acid (70 ml), and the resulting mixture was stirred at 25°C. 5 hours until TLC showed the reaction was complete. Concentrate under reduced pressure to obtain a mixture. Water (30 mL) was added to the mixture, the mixture was basified to pH=8.0 with aqueous ammonia solution, and the mixture was extracted three times with dichloromethane (50 mLx3). The organic extracts were combined and washed with water and brine. The organic extract was dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated under reduced pressure to obtain Thiomorpholine 1,1-dioxide.
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 158, p. 247 - 258
[2] Patent: US2006/100426, 2006, A1. Location in patent: Page/Page column 17
[3] Patent: US2006/135764, 2006, A1. Location in patent: Page/Page column 21
[4] Patent: US2006/100236, 2006, A1. Location in patent: Page/Page column 19
[5] Patent: US2006/199839, 2006, A1. Location in patent: Page/Page column 21
Thiomorpholine-1,1-dioxide Preparation Products And Raw materials
Raw materials
Preparation Products
Thiomorpholine-1,1-dioxide Suppliers
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View Lastest Price from Thiomorpholine-1,1-dioxide manufacturers
- Product
- Thiomorpholine-1,1-dioxide 39093-93-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000kg
- Release date
- 2025-04-17
- Product
- Thiomorpholine-1,1-dioxide 39093-93-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- Thiomorpholine-1,1-dioxide 39093-93-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2019-12-31