THIOMORPHOLINE 1,1-DIOXIDE HYDROCHLORIDE
Uses- Product Name
- THIOMORPHOLINE 1,1-DIOXIDE HYDROCHLORIDE
- CAS No.
- 59801-62-6
- Chemical Name
- THIOMORPHOLINE 1,1-DIOXIDE HYDROCHLORIDE
- Synonyms
- EOS-60876;THIOMORPHOLINE 1;1-DIOXIDE HYDROCHLORIDE;ine 1,1-dioxide hydrochL;1,4-thiazinane1,1-dioxide;THIOMORPHOLINE 1,1-DIOXIDE HCL;Thiomorpholine dioxide hydrogen;1,1-dioxothiomorpholine hydrochloride;s,s-dioxythiomorpholine hydrochloride;THIOMORPHOLINE-1,1-OXIDE HYDROCHLORIDE
- CBNumber
- CB8453664
- Molecular Formula
- C4H10ClNO2S
- Formula Weight
- 171.65
- MOL File
- 59801-62-6.mol
THIOMORPHOLINE 1,1-DIOXIDE HYDROCHLORIDE Property
- Melting point:
- 307 °C (decomp)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- color
- White
- InChI
- InChI=1S/C4H9NO2S.ClH/c6-8(7)3-1-5-2-4-8;/h5H,1-4H2;1H
- InChIKey
- UOMTVKMKHZMFMQ-UHFFFAOYSA-N
- SMILES
- C1S(=O)(=O)CCNC1.[H]Cl
Safety
- HazardClass
- IRRITANT
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- T430020
- Product name
- Thiomorpholine-1,1-dioxideHydrochloride
- Packaging
- 5mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- T430020
- Product name
- Thiomorpholine-1,1-dioxideHydrochloride
- Packaging
- 25mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 290867
- Product name
- Thiomorpholine-1,1-dioxide HCl
- Packaging
- 2g
- Price
- $333
- Updated
- 2021/12/16
- Product number
- P000368984
- Product name
- Thiomorpholine 1,1-dioxide hydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $8
- Updated
- 2021/12/16
- Product number
- P000368984
- Product name
- Thiomorpholine 1,1-dioxide hydrochloride
- Purity
- 97%
- Packaging
- 10g
- Price
- $37
- Updated
- 2021/12/16
THIOMORPHOLINE 1,1-DIOXIDE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
Thiomorpholine 1,1-dioxide hydrochloride is used as a pharmaceutical intermediate.
Chemical Properties
white to light yellow solid
Synthesis
215791-95-0
59801-62-6
The general procedure for the synthesis of thiomorpholine-1,1-dioxide hydrochloride from tert-butyl thiomorpholine-4-carboxylate 1,1-dioxide was as follows: tert-butyl 1,1-dioxothiomorpholine-4-carboxylate (2.03 g, 8.63 mmol) was dissolved in a hydrochloric acid-methanol (10%, 20 mL, purchased from Tokyo Kasei Kogyo Co.) and tetrahydrofuran (20 mL) in a solvent mixture. Concentrated hydrochloric acid (4.0 mL) was slowly added to the reaction system under stirring at room temperature. The reaction mixture was continued to be stirred at room temperature for 3 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure. Methanol (20 mL), tetrahydrofuran (20 mL), and concentrated hydrochloric acid (4.0 mL) were added to the resulting solid, followed by the addition of water (10 mL) to ensure complete dissolution of the solid. This solution was stirred at room temperature for 1 hour. The solvent was again concentrated under reduced pressure to remove the solvent. The resulting crystals were suspended in methanol, filtered, washed with methanol and dried under ventilated conditions to give thiomorpholine-1,1-dioxide hydrochloride as colorless crystals (1.49 g, 8.65 mmol, quantitative yield). The product was characterized by 1H-NMR (DMSO-d6): δ 3.54 (8H, m), 9.83 (2H, brs).
References
[1] Patent: EP1522540, 2005, A1. Location in patent: Page/Page column 70
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 20, p. 9541 - 9559
THIOMORPHOLINE 1,1-DIOXIDE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from THIOMORPHOLINE 1,1-DIOXIDE HYDROCHLORIDE manufacturers
- Product
- THIOMORPHOLINE 1,1-DIOXIDE HYDROCHLORIDE 59801-62-6
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-11-14
- Product
- Thiomorpholine-1,1-dioxide hydrochloride 59801-62-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- THIOMORPHOLINE 1,1-DIOXIDE HYDROCHLORIDE 59801-62-6
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-10