ChemicalBook > CAS DataBase List > Thiomorpholine-1,1-dioxide

Thiomorpholine-1,1-dioxide

Product Name
Thiomorpholine-1,1-dioxide
CAS No.
39093-93-1
Chemical Name
Thiomorpholine-1,1-dioxide
Synonyms
THIOMORPHOLINE 1,1-DIOXIDE;1,1-DIOXOTHIOMORPHOLINE;DK771;DKSI157;EOS-62289;TIMTEC-BB SBB010267;THIOMORPHOLINE DIOXIDE;Thiomorpholine-1,1-oxide;1,1-DioxidothioMorpholine;ThioMorpholine-1,1-dioxid
CBNumber
CB7140484
Molecular Formula
C4H9NO2S
Formula Weight
135.18
MOL File
39093-93-1.mol
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Thiomorpholine-1,1-dioxide Property

Melting point:
0°C
Boiling point:
0°C
Density 
1.239±0.06 g/cm3(Predicted)
Flash point:
0°C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
6.48±0.20(Predicted)
color 
White to Off-White
InChI
InChI=1S/C4H9NO2S/c6-8(7)3-1-5-2-4-8/h5H,1-4H2
InChIKey
NDOVLWQBFFJETK-UHFFFAOYSA-N
SMILES
N1CCS(=O)(=O)CC1
CAS DataBase Reference
39093-93-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
T2193
Product name
Thiomorpholine 1,1-Dioxide
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$170
Updated
2025/07/31
TCI Chemical
Product number
T2193
Product name
Thiomorpholine 1,1-Dioxide
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$523
Updated
2025/07/31
TRC
Product number
T344568
Product name
Thiomorpholine 1,1-Dioxide
Packaging
50mg
Price
$55
Updated
2021/12/16
Usbiological
Product number
291067
Product name
Thiomorpholine 1,1-Dioxide
Packaging
1g
Price
$396
Updated
2021/12/16
TRC
Product number
T344568
Product name
Thiomorpholine 1,1-Dioxide
Packaging
10mg
Price
$45
Updated
2021/12/16
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Thiomorpholine-1,1-dioxide Chemical Properties,Usage,Production

Chemical Properties

light yellow solid

Uses

Thiomorpholine 1,1-Dioxide is a useful building block, used in the synthetic preparation of antibacterial biaryloxazolidinone analogues, and isothiazolo-pyridine derivatives for use as cyclin G-associated kinase inhibitors and antiviral agents.

Synthesis

To a solution of tert-butylthiomorpholine-4-carboxylate (5.8 g, 0.024 mol) in dichloromethane (50 ml) was added trifluoroacetic acid (70 ml), and the resulting mixture was stirred at 25°C. 5 hours until TLC showed the reaction was complete. Concentrate under reduced pressure to obtain a mixture. Water (30 mL) was added to the mixture, the mixture was basified to pH=8.0 with aqueous ammonia solution, and the mixture was extracted three times with dichloromethane (50 mLx3). The organic extracts were combined and washed with water and brine. The organic extract was dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated under reduced pressure to obtain Thiomorpholine 1,1-dioxide.

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 158, p. 247 - 258
[2] Patent: US2006/100426, 2006, A1. Location in patent: Page/Page column 17
[3] Patent: US2006/135764, 2006, A1. Location in patent: Page/Page column 21
[4] Patent: US2006/100236, 2006, A1. Location in patent: Page/Page column 19
[5] Patent: US2006/199839, 2006, A1. Location in patent: Page/Page column 21

Thiomorpholine-1,1-dioxide Preparation Products And Raw materials

Raw materials

Thiomorpholine Hydrogen peroxide

Preparation Products

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View Lastest Price from Thiomorpholine-1,1-dioxide manufacturers

Shaanxi Xianhe Biotech Co., Ltd
Product
Thiomorpholine-1,1-dioxide 39093-93-1
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
1000kg
Release date
2025-04-17
Henan Aochuang Chemical Co.,Ltd.
Product
Thiomorpholine-1,1-dioxide 39093-93-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08
Shaanxi Dideu Medichem Co. Ltd
Product
Thiomorpholine-1,1-dioxide 39093-93-1
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
99%
Supply Ability
2000tons
Release date
2019-12-31

39093-93-1, Thiomorpholine-1,1-dioxideRelated Search:

THIOMORPHOLINE 1,1-DIOXIDE HYDROCHLORIDE Thiomorpholine THIOMORPHOLINE-3-CARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE ThioMorpholine-1-oxide HCl thiomorpholin-3-one ALPHA-[BUTYLAMINO]METHYL-P-HYDROXYBENZYL ALCOHOL THIOACETIC ACID S-(2-AMINO-ETHYL) ESTERHYDROCHLORIDE 3-INDOXYL SULFATE POTASSIUM SALT 4-PHENYLTHIOMORPHOLINE 1,1-DIOXIDE 4-METHYLTHIOMORPHOLINE 1,1-DIOXIDE 4-PROPARGYLTHIOMORPHOLINE 1,1-DIOXIDE 4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE 4-BENZYLTHIOMORPHOLINE 1,1-DIOXIDE 4-(3-HYDROXYPROPYL)THIOMORPHOLINE 1,1-DIOXIDE 4-ALLYL-1LAMBDA6,4-THIAZINANE-1,1-DIONE 4-(2-FURYLMETHYL)-1LAMBDA6,4-THIAZINANE-1,1-DIONE (1,1-DIOXOTHIOMORPHOLINO)ACETIC ACID MONOHYDRATE 4-[4-[(2,6-dichloro-4-nitrophenyl)azo]phenyl]thiomorpholine 1,1-dioxide

  • THIOMORPHOLINE DIOXIDE
  • THIOMORPHOLINE 1,1-DIOXIDE
  • TIMTEC-BB SBB010267
  • 1,1-DIOXOTHIOMORPHOLINE
  • 1,1-DIOXIDE-4-THIOMORPHOLINE
  • Thiomorpholine-1,1-oxide
  • thiomorpholine 1,1-dioxide(SALTDATA: HCl)
  • ThioMorpholine-1,1-dioxid
  • 1$l^{6},4-thioMorpholine-1,1-dione
  • 1,1-DioxidothioMorpholine
  • 1,4-Thiazinane 1,1-dioxide, 1,1-Dioxidothiomorpholine
  • EOS-62289
  • Thiomorpholine, 1,1-dioxide (7CI, 9CI, ACI)
  • DK771
  • DKSI157
  • 39093-93-1
  • 500-57-9
  • Heterocycles series