2-GUANIDINOBENZIMIDAZOLE

Product Name: 2-GUANIDINOBENZIMIDAZOLE
CAS No.: 5418-95-1
Chemical Name: 2-GUANIDINOBENZIMIDAZOLE
Synonyms: AKOS BC-1905;TIMTEC-BB SBB003790;TOSLAB-BB TOS-BB-1283;OTAVA-BB BB0111070250;2-Guanidinobenzimiazole;2-GUANIDINOBENZIMIDAZOLE;2-benzimidazolylguanidine;2-GUANIDINOBENZIMIDAZOLE 95%;2-Guanidinobenzimidazole,95%;1h-benzimidazol-2-yl-guanidin
CBNumber: CB9773033
Molecular Formula: C8H9N5
Formula Weight: 175.19
MOL File: 5418-95-1.mol

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2-GUANIDINOBENZIMIDAZOLE Property

Melting point:: 242-244 °C (dec.) (lit.)
Boiling point:: 296.48°C (rough estimate)
Density: 1.2954 (rough estimate)
refractive index: 1.6900 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in DMSO (up to 50 mg/ml) or in Water (up to 4 mg/ml with warming)
pka: 13.67±0.30(Predicted)
form: solid
color: Beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 5418-95-1(CAS DataBase Reference)
EPA Substance Registry System: Guanidine, 1H-benzimidazol-2-yl- (5418-95-1)

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Safety

WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G11802
Product name: 2-Guanidinobenzimidazole
Purity: 95%
Packaging: 5g
Price: $66.5
Updated: 2024/03/01

TRC

Product number: B197035
Product name: N-1H-Benzimidazol-2-ylguanidine
Packaging: 2.5g
Price: $120
Updated: 2021/12/16

Usbiological

Product number: 457868
Product name: N-1H-Benzimidazol-2-ylguanidine
Packaging: 500mg
Price: $319
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H41-1-05
Product name: 2-Guanidinobenzimiazole
Packaging: 5G
Price: $248
Updated: 2021/12/16

Matrix Scientific

Product number: 065372
Product name: N-1H-Benzimidazol-2-ylguanidine
Packaging: 500mg
Price: $315
Updated: 2021/12/16

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2-GUANIDINOBENZIMIDAZOLE Chemical Properties,Usage,Production

Description

2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1?2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3? Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4

Chemical Properties

BROWN-PURPLE FINE CRYSTALLINE POWDER

Uses

N-1H-Benzimidazol-2-ylguanidine is used as a reagent in the synthesis of novel fused pyrimidines and imidazoles as potential analgesics.

Definition

ChEBI: 2-Benzimidazolylguanidine is an aminoimidazole.

References

1) Hong?et al. (2015),?Interrogation of the intersubunit interface if the open Hv1 proton channel with a probe of allosteric coupling; Sci. Rep.,?5?14077 2) Hong?et al.?(2014),?Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives; Proc. Natl. Acad. Sci. USA,?111?9971 3) Gianti?et al. (2016),?On the role of water density fluctuations in the inhibition of a proton channel; Proc. Natl. Acad. Sci. USA,?113?E8359 4) Pupo and Gonzalez (2014),?In pursuit of an inhibitory drug for the proton channel; Proc. Natl. Acad. Sci. USA,?111?9673

2-GUANIDINOBENZIMIDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-GUANIDINOBENZIMIDAZOLE Suppliers

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5418-95-1, 2-GUANIDINOBENZIMIDAZOLERelated Search:

2-GUANIDINOBENZIMIDAZOLE Benzimidazole N-(5-CHLORO-1H-BENZIMIDAZOL-2-YL)GUANIDINE 4-(2-CHLOROPHENYL)-1,4-DIHYDRO[1,3,5]TRIAZINO[1,2-A][1,3]BENZIMIDAZOL-2-AMINE AKOS BBS-00005568 4-(4-CHLORO-PHENYL)-1,4-DIHYDRO-BENZO[4,5]IMIDAZO[1,2-A][1,3,5]TRIAZIN-2-YLAMINE 4-(4-FLUOROPHENYL)-1,4-DIHYDRO[1,3,5]TRIAZINO[1,2-A][1,3]BENZIMIDAZOL-2-AMINE AKOS BBS-00005576 AKOS BBS-00005563 4-THIOPHEN-2-YL-1,4-DIHYDRO-BENZO[4,5]IMIDAZO[1,2-A][1,3,5]TRIAZIN-2-YLAMINE AKOS BBS-00005569 N-(5,6-DIMETHYL-1H-BENZIMIDAZOL-2-YL)GUANIDINE AKOS BBS-00005564 4-(3,4,5-TRIMETHOXY-PHENYL)-1,4-DIHYDRO-BENZO[4,5]IMIDAZO[1,2-A][1,3,5]TRIAZIN-2-YLAMINE AKOS BBS-00005572 AKOS BBS-00005575 4-(4-METHOXY-PHENYL)-1,4-DIHYDRO-BENZO[4,5]IMIDAZO[1,2-A][1,3,5]TRIAZIN-2-YLAMINE 4-(3-PYRIDYL)-1,4-DIHYDRO[1,3,5]TRIAZINO[1,2-A][1,3]BENZIMIDAZOL-2-AMINE

2-benzimidazolylguanidine

N-1H-benzimidazol-2-ylguanidine hydrate

1-(1H-Benzimidazol-2-yl)guanidine

2-(Diaminomethyleneamino)-1H-benzimidazole

AKOS BC-1905

2-GUANIDINOBENZIMIDAZOLE

OTAVA-BB BB0111070250

TOSLAB-BB TOS-BB-1283

TIMTEC-BB SBB003790

1h-benzimidazol-2-yl-guanidin

1-(benzimidazol-2-yl)guanidine

2-GUANIDINOBENZIMIDAZOLE 95%

Guanidine, 1H-benzimidazol-2-yl- (9CI)

N-(1H-1,3-benzodiazol-2-yl)guanidine

2-Guanidinobenzimiazole

2-(3aH-benzimidazol-2-yl)guanidine

1-(1H-Benzo[d]imidazol-2-yl)guanidine

2-[(Diaminomethylene)amino]-1H-benzimidazole

2-Guanidinobenzimidazole,95%

N-1H-Benzimidazol-2-ylguanidine

Guanidine, N-1H-benzimidazol-2-yl-

5418-95-1

C8H9N5

C8H10N5

Benzimidazoles

Building Blocks

Heterocyclic Building Blocks

BENZIMIDAZOLE

Benzimidazoles

Building Blocks

Heterocyclic Building Blocks

Building Blocks

Chemical Synthesis

Heterocyclic Building Blocks