2-GUANIDINOBENZIMIDAZOLE
- Product Name
- 2-GUANIDINOBENZIMIDAZOLE
- CAS No.
- 5418-95-1
- Chemical Name
- 2-GUANIDINOBENZIMIDAZOLE
- Synonyms
- AKOS BC-1905;TIMTEC-BB SBB003790;TOSLAB-BB TOS-BB-1283;OTAVA-BB BB0111070250;2-Guanidinobenzimiazole;2-GUANIDINOBENZIMIDAZOLE;2-benzimidazolylguanidine;2-GUANIDINOBENZIMIDAZOLE 95%;2-Guanidinobenzimidazole,95%;1h-benzimidazol-2-yl-guanidin
- CBNumber
- CB9773033
- Molecular Formula
- C8H9N5
- Formula Weight
- 175.19
- MOL File
- 5418-95-1.mol
2-GUANIDINOBENZIMIDAZOLE Property
- Melting point:
- 242-244 °C (dec.) (lit.)
- Boiling point:
- 296.48°C (rough estimate)
- Density
- 1.2954 (rough estimate)
- refractive index
- 1.6900 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO (up to 50 mg/ml) or in Water (up to 4 mg/ml with warming)
- pka
- 13.67±0.30(Predicted)
- form
- solid
- color
- Beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
- CAS DataBase Reference
- 5418-95-1(CAS DataBase Reference)
- EPA Substance Registry System
- Guanidine, 1H-benzimidazol-2-yl- (5418-95-1)
Safety
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- G11802
- Product name
- 2-Guanidinobenzimidazole
- Purity
- 95%
- Packaging
- 5g
- Price
- $66.5
- Updated
- 2024/03/01
- Product number
- B197035
- Product name
- N-1H-Benzimidazol-2-ylguanidine
- Packaging
- 2.5g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 457868
- Product name
- N-1H-Benzimidazol-2-ylguanidine
- Packaging
- 500mg
- Price
- $319
- Updated
- 2021/12/16
- Product number
- 3H41-1-05
- Product name
- 2-Guanidinobenzimiazole
- Packaging
- 5G
- Price
- $248
- Updated
- 2021/12/16
- Product number
- 065372
- Product name
- N-1H-Benzimidazol-2-ylguanidine
- Packaging
- 500mg
- Price
- $315
- Updated
- 2021/12/16
2-GUANIDINOBENZIMIDAZOLE Chemical Properties,Usage,Production
Description
2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1?2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3? Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4
Chemical Properties
BROWN-PURPLE FINE CRYSTALLINE POWDER
Uses
N-1H-Benzimidazol-2-ylguanidine is used as a reagent in the synthesis of novel fused pyrimidines and imidazoles as potential analgesics.
Definition
ChEBI: 2-Benzimidazolylguanidine is an aminoimidazole.
References
1) Hong?et al. (2015),?Interrogation of the intersubunit interface if the open Hv1 proton channel with a probe of allosteric coupling; Sci. Rep.,?5?14077 2) Hong?et al.?(2014),?Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives; Proc. Natl. Acad. Sci. USA,?111?9971 3) Gianti?et al. (2016),?On the role of water density fluctuations in the inhibition of a proton channel; Proc. Natl. Acad. Sci. USA,?113?E8359 4) Pupo and Gonzalez (2014),?In pursuit of an inhibitory drug for the proton channel; Proc. Natl. Acad. Sci. USA,?111?9673