ChemicalBook > CAS DataBase List > 1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE

1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE

Product Name
1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE
CAS No.
98224-03-4
Chemical Name
1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE
Synonyms
DU-28853;EltoprazineHCl;Eltoprazine (DU-28853);ELTOPRAZINE HYDROCHLORIDE;5-Piperazino-2,3-dihydro-1,4-benzodioxin;5-(Piperazin-1-yl)-2,3-dihydro-1,4-benzodioxin;N-(2,3-Dihydrobenzo[1,4]dioxin-5-yl)piperazine;4(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazine;1-[(2,3-Dihydro-1,4-benzodioxin)-5-yl]piperazine;Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-
CBNumber
CB9777521
Molecular Formula
C12H16N2O2
Formula Weight
220.27
MOL File
98224-03-4.mol
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1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE Property

storage temp. 
Store at RT
solubility 
DMSO : ≥ 25 mg/mL (113.50 mM)
form 
Powder
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E507503
Product name
Eltoprazine
Packaging
10mg
Price
$160
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611664
Product name
Eltoprazine hydrochloride
Packaging
100mg
Price
$510
Updated
2021/12/16
Matrix Scientific
Product number
187791
Product name
1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)piperazine
Packaging
500mg
Price
$750
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611664
Product name
Eltoprazine hydrochloride
Packaging
250mg
Price
$765
Updated
2021/12/16
Matrix Scientific
Product number
187791
Product name
1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)piperazine
Packaging
1g
Price
$1200
Updated
2021/12/16
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1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Eltoprazine is a partial agonist at SR-1 and SR-2C. Also, it is a 5-HT1A/1B receptor agonist.

Biological Activity

5-HT 1 and 5-HT 2C receptor partial agonist (K i values are 40, 52 and 81 nM for 5-HT 1A , 5-HT 1B and 5-HT 2C receptors respectively). Reduces 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo .

in vivo

Rats are chronically treated with Mianserin (10 mg/kg i.p.) or Eltoprazine (1 mg/kg i.p.) and are tested in the elevated plus-maze test for anxiety. Mianserin and Eltoprazine display opposite effects in the elevated plus-maze: Mianserin induces anxiolytic-like effects, while Eltoprazine shows anxiogenic-like ones[2].

IC 50

5-HT1A Receptor; 5-HT1B Receptor; 5-HT2C Receptor

1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE Suppliers

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View Lastest Price from 1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Eltoprazine 98224-03-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Eltoprazine 98224-03-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

98224-03-4, 1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDERelated Search:

HEXAETHYLDISILOXANE Phthalan Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride 2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBONITRILE 6-(bromomethyl)-2,3-dihydrobenzo[b][1,4]dioxine 2,3-DIHYDRO-1,4-BENZODIOXINE-5-CARBONYL CHLORIDE 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid 5-Amino-1,4-benzodioxane 6-Bromo-1,3-benzodioxole-4-carbaldehyde 2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHANOL 4-BROMO-1,3-BENZODIOXOLE (6-Bromo-benzo[1,3]dioxol-4-)-methylamine 1,4-Benzodioxin-2-Methanol, 6-aMino-2,3-dihydro- 1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE 2-HYDROXYMETHYL-5-(1-PIPERAZINYL)-1,4-BENZODIOXANE-BENZOATE HYDROCHLORIDE 1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-4-(2,3-DIHYDRO-1H-INDEN-2-YL)-PIPERAZINE Flesinoxan FLESINOXAN

  • 1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE
  • ELTOPRAZINE HYDROCHLORIDE
  • 1-[(2,3-Dihydro-1,4-benzodioxin)-5-yl]piperazine
  • 5-(Piperazin-1-yl)-2,3-dihydro-1,4-benzodioxin
  • 5-Piperazino-2,3-dihydro-1,4-benzodioxin
  • DU-28853
  • 1-(2,3-DIHYDROBENZO[B][1,4]DIOXIN-5-YL)PIPERAZINE HYDROCHLORIDE
  • 4(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazine
  • N-(2,3-Dihydrobenzo[1,4]dioxin-5-yl)piperazine
  • EltoprazineHCl
  • Eltoprazine (DU-28853)
  • Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-
  • 98224-03-4
  • Pyrans, Piperidines &Piperazines
  • Pyrans, Piperidines & Piperazines