ChemicalBook > CAS DataBase List > Propylthiouracil

Propylthiouracil

Product Name
Propylthiouracil
CAS No.
51-52-5
Chemical Name
Propylthiouracil
Synonyms
T 72;6-PTU;PROPYCIL;PROPACIL;PROCASIL;NSC 6498;PROTHYRAN;NSC 70461;Prothycil;Protiural
CBNumber
CB9777662
Molecular Formula
C7H10N2OS
Formula Weight
170.23
MOL File
51-52-5.mol
More
Less

Propylthiouracil Property

Melting point:
218-220 °C (lit.)
Density 
1.1880 (rough estimate)
refractive index 
1.5960 (estimate)
Flash point:
300 °C
storage temp. 
2-8°C
solubility 
1.1g/l
pka
pKa 7.8; 8.3 (Uncertain)
form 
Solid
color 
White
PH
6-7.5 (5g/l, H2O, 20℃)(slurry)
Water Solubility 
1.1 g/L
Merck 
14,7869
BRN 
130039
BCS Class
3
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive.
CAS DataBase Reference
51-52-5(CAS DataBase Reference)
NIST Chemistry Reference
Tegretol(51-52-5)
IARC
2B (Vol. Sup 7, 79) 2001
EPA Substance Registry System
Propylthiouracil (51-52-5)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-40
Safety Statements 
36/37-45
WGK Germany 
3
RTECS 
YR1400000
Hazard Note 
Harmful/Irritant
HS Code 
29335995
Hazardous Substances Data
51-52-5(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 1250 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H351Suspected of causing cancer

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2609
Product name
Propylthiouracil
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500MG
Price
$200
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22137
Product name
4-Propyl-2-thiouracil
Purity
for synthesis
Packaging
25g
Price
$55.1
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22137
Product name
4-Propyl-2-thiouracil
Purity
for synthesis
Packaging
100g
Price
$183
Updated
2024/03/01
Sigma-Aldrich
Product number
46698
Product name
6-Propyl-2-thiouracil
Purity
VETRANAL , analytical standard
Packaging
250mg
Price
$71.1
Updated
2024/03/01
Sigma-Aldrich
Product number
1578000
Product name
Propylthiouracil
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$261.6
Updated
2024/03/01
More
Less

Propylthiouracil Chemical Properties,Usage,Production

Description

Propylthiouracil (PTU) is a thioamide antithyroid agent. It inhibits thyroid peroxidase activity in rat and monkey thyroid microsomes (IC50s = 0.081 and 4.1 μM, respectively). PTU (30 mg/kg) increases thyroid weight and serum thyroid stimulating hormone levels and decreases serum 3,5,3''-triiodothyronine and thyroxine levels in rats. Sensitivity to the bitter taste of PTU is genetically mediated and is associated with increased sensitivity to other sweet and bitter compounds. Formulations containing propylthiouracil have been used in the treatment of Graves'' disease and hyperthyroidism.

Chemical Properties

White Crystalline Powder

Chemical Properties

White crystalline solid or powder. Odorless. Bitter taste.

Uses

antibacterial

Uses

Antihyperthyroid. Has been used to promote fattening. This substance is reasonably anticipated to be a human carcinogen.

Definition

ChEBI: A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group.

General Description

Odorless white crystalline powder of starch-like appearance. Bitter taste. Saturated solution is neutral or slightly acid to litmus.

General Description

Propylthiouracil, 6-propyl-2-thiouracil (Propacil), is a stable, white, crystalline powderwith a bitter taste. It is slightly soluble in water but readilysoluble in alkaline solutions (salt formation).

Air & Water Reactions

Sensitive to light. May be sensitive to prolonged exposure to air. Insoluble in water.

Reactivity Profile

Propylthiouracil is incompatible with strong oxidizing agents, strong acids and strong bases. Forms complexes with divalent metals. Reacts with sulfhydryl-oxidizing agents . When reduced will produce hydrogen sulfide.

Hazard

Possible carcinogen.

Fire Hazard

Flash point data for Propylthiouracil are not available; however Propylthiouracil is probably combustible.

Biochem/physiol Actions

6-Propyl-2-thiouracil (6-PTU), a potential inhibitor of D1 iodothyronine deiodinase, is involved in the deiodination of iodothyronines. It is an uncompetitive inhibitor of iodothyronine substrates.

Mechanism of action

This drug has a pronounced thyrostatic effect and causes reduced thyroxine synthesis in the thyroid gland. It inhibits the process of iodination of thyroglobulin, reduces formation of the active form of iodine in the thyroid gland, and blocks the peroxidase system. Propylthiouracil is used for hyperthyrosis, thyrotoxic crises, and on thyrodectomia. Synonyms of this drug are propycil and tireostat.

Clinical Use

Propylthiouracil is useful in the treatment of hyperthyroidism.There is a delay in appearance of its effects because propylthiouracildoes not interfere with the activity of thyroid hormonesalready formed and stored in the thyroid gland. Thislag period may vary from several days to weeks, dependingon the condition of the patient. The need for three equallyspaced doses during a 24-hour period is often stressed, butevidence now indicates that a single daily dose is as effectiveas multiple daily doses in the treatment of most hyperthyroidpatients.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects: agranulocytosis, hepatitis, jaundice. Human teratogenic effects by ingestion: developmental abnormalities of the endocrine system and changes in newborn viability. Human and experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and NO,. See also MERCAPTANS.

Synthesis

Propylthiouracil, 6-propyl-2-thio-2,4-(1H,3H)-pyrimidindione (25.2.2), is synthesized by condensating ethyl butyroacetate with thiourea in the presence of sodium ethoxide.

Potential Exposure

Medication (antihyperthyroid; thyroid inhibitor) with human and veterinary applications.

Carcinogenicity

Propylthiouracil is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.

Metabolism

Propylthiouracil undergoes rapid first-pass metabolism in the liver, and is mainly excreted in the urine as the glucuronic acid conjugate, with very little excreted as unchanged drug.

Shipping

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Purify propacil by recrystallisation from H2O (soluble in 900 parts at 20o, and 100 parts at 100o). UV, MeOH: max 277nm. [Anderson et al. J Am Chem Soc 67 2197 1945, Vanderhaegue Bull Soc Chim Belg 59 689 1950, Beilstein 24 III/IV 1333.]

Incompatibilities

This chemical is probably combustible; it’s dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanga- nates, perchlorates, chlorine, bromine, fluorine, etc.); con- tact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Forms complexes with divalent metals. Reacts with sulfhydryl-oxidizing agents . Sensitive to light and may be sensitive to air.

Waste Disposal

It is inappropriate and possi- bly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding to trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely pack- age the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Propylthiouracil Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Propylthiouracil Suppliers

Americas 1 Belgium 4 Brazil 1 Canada 1 China 352 Egypt 1 Europe 4 France 2 Germany 11 India 8 Italy 2 Japan 5 Slovakia 1 South Korea 1 Spain 1 Switzerland 3 Ukraine 1 United Kingdom 18 United States 43 Global 460
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
ProdList
10404
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
ZETA Pharmaceuticals, L.L.C.
Tel
--
Fax
--
Email
zeta@zetapharm.com
Country
United States
ProdList
102
Advantage
58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
Chiral Management
Tel
--
Fax
--
Email
sales@chiralmanagement.com
Country
United States
ProdList
1332
Advantage
30
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
Lab Express
Tel
--
Fax
--
Email
sales@labexpress.com
Country
United States
ProdList
1577
Advantage
67
City Chemicals Corporation
Tel
--
Fax
--
Country
United States
ProdList
6460
Advantage
72
George Uhe Co., Inc.
Tel
--
Fax
--
Email
global@uhe.com
Country
United States
ProdList
520
Advantage
65
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
SST Corporation
Tel
--
Fax
--
Email
info@sst-corp.com
Country
United States
ProdList
237
Advantage
38
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
More
Less

View Lastest Price from Propylthiouracil manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Propylthiouracil 51-52-5
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000KG
Release date
2021-06-08
Hebei Weibang Biotechnology Co., Ltd
Product
Propylthiouracil 51-52-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-21
Hebei Yanxi Chemical Co., Ltd.
Product
Propylthiouracil 51-52-5
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-16

51-52-5, PropylthiouracilRelated Search:

Thioacetic acid Calcium thioglycolate 2-Ethylhexyl mercaptoacetate POTASSIUM THIOGLYCOLATE 6-Mercaptopurine Thioacetamide Potassium thioacetate 3-Mercaptopropionic acid Sodium thioglycolate CHLOROPHOSPHONAZO III Sodium thiosulfate 2-Thiobarbituric acid 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL Methylthiouracil Mercaptoacetic acid Tetrapropylammonium hydroxide 4-Hydroxypyrimidine Malathion

  • 2,3-dihydro-6-propyl-2-thioxo-4(1h)-pyrimidinon
  • 2,3-dihydro-6-propyl-2-thioxo-4(1h)pyrimidinone
  • 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone
  • 2-Mercapto-4-hydroxy-6-n-propylpyrimidine
  • 2-Mercapto-6-propyl-4-pyrimidone
  • 4(1H)-Pyrimidinone, 2,3-dihydro-6-propyl-2-thioxo-
  • 6-n-Propylthiouracil
  • 6-Propil-tiouracile
  • 6-Propyl-2-sulfanyl-4-pyrimidinol
  • 6-propyl-2-thio-2,4(1h,3h)pyrimidinedione
  • 6-Propyl-2-thio-2,4(1H,3H)-pyrimidinedione
  • 6-PROPYL-2-THIOURACIL
  • 2-mercapto-6-propylpyrimid-4-one
  • 2-THIO-4-HYDROXY-6-N-PROPYL-PYRIMIDINE
  • 2-THIO-4-OXO-6-PROPYL-1,3-PYRIMIDINE
  • 2-THIO-6-PROPYL-1,3-PYRIMIDIN-4-ONE
  • PROPYCIL
  • PROPYLTHIOURACIL
  • PROTHYRAN
  • PROPACIL
  • PROCASIL
  • OTAVA-BB BB7012240174
  • 6-PROPYL-2-THIOURACYLE
  • 6-PROPYL-2-THIOURACILE VETRANAL, 250
  • PropylthiouracilB.P./U.S.P.
  • Propyl-2-thiouracil
  • NSC 6498
  • NSC 70461
  • 4-HYDROXY-2-MERCAPTO-6-PROPYLPYRIMIDINE 98%
  • 6-Propyl-2-thiouracil ,99%
  • 4-Hydroxy-2-mercapto-6-propylpyrimidine,98%
  • 6-Propyl-2-thiouracil,4-Hydroxy-2-mercapto-6-propylpyrimidine
  • Propylthiouracil (200 mg)
  • Propylthiouracil, USP
  • 3-propyl-2-sulfanylidene-1H-pyrimidin-4-one
  • 6-propyl-2-thio-uraci
  • 6-Propylthiouracil
  • 6-Thio-4-propyluracil
  • Propilthiouracil
  • Propyl-Thiorist
  • Propylthiorit
  • propyl-thiorit
  • Propyl-Thyracil
  • Propythiouracil
  • Prothiucil
  • Prothiurone
  • Prothycil
  • Protiural
  • ptu(thyreostatic)
  • T 72
  • Thiuragyl
  • Thyreostat II
  • thyreostatii
  • Uracil, 6-propyl-2-thio-
  • 4-HYDROXY-2-MERCAPTO-6-PROPYLPYRIMIDINE
  • 4-PROPYL-2-THIOURACIL
  • 6-N-PROPYL-2-MERCAPTO-4-HYDROXYPYRIMIDINE
  • 6-N-PROPYL-2-THIOURACIL