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6-CHLORO-N-METHYL-NICOTINAMIDE

Product Name
6-CHLORO-N-METHYL-NICOTINAMIDE
CAS No.
54189-82-1
Chemical Name
6-CHLORO-N-METHYL-NICOTINAMIDE
Synonyms
6-CHLORO-N-METHYL-NICOTINAMIDE;6-chloro-nicotinic acid N-MethylaMide;3-Pyridinecarboxamide, 6-chloro-N-methyl-
CBNumber
CB9786486
Molecular Formula
C7H7ClN2O
Formula Weight
170.6
MOL File
54189-82-1.mol
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6-CHLORO-N-METHYL-NICOTINAMIDE Property

Melting point:
152.8-153.4 °C(Solv: dichloromethane (75-09-2))
Boiling point:
347.6±27.0 °C(Predicted)
Density 
1.264±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
13.85±0.46(Predicted)
Appearance
White to light yellow Solid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.43924
Product name
6-Chloro-N-methyl nicotinamide
Purity
for synthesis
Packaging
5G
Price
$75.6
Updated
2022/05/15
Sigma-Aldrich
Product number
8.43924
Product name
6-Chloro-N-methyl nicotinamide
Purity
for synthesis
Packaging
25g
Price
$153
Updated
2022/05/15
TRC
Product number
C428858
Product name
6-Chloro-N-methyl nicotinamide
Packaging
100mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
5281AE
Product name
6-Chloro-N-methyl nicotinamide
Packaging
10g
Price
$384
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0055430
Product name
6-Chloro-N-methyl nicotinamide
Purity
95.00%
Packaging
1G
Price
$852.55
Updated
2021/12/16
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6-CHLORO-N-METHYL-NICOTINAMIDE Chemical Properties,Usage,Production

Synthesis

58757-38-3

74-89-5

54189-82-1

a) Preparation of 6-chloro-N-methylnicotinamide: 6-chloro-3-pyridinecarbonyl chloride (5.65 g, 32.1 mmol) was dissolved in tetrahydrofuran (64 mL), and triethylamine (5.59 mL, 40.1 mmol) and tetrahydrofuran solution of methylamine (20.1 mL, 40.1 mmol) were added sequentially, and the reaction was carried out under the condition of ice bath. After addition, the ice bath was withdrawn and the reaction was stirred at room temperature for 3.5 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure and the resulting residue was purified by recrystallization (ethyl acetate/hexane) to afford 6-chloro-N-methyl-nicotinamide (5.06 g, 92% yield) as light brown crystals.1H-NMR (CDCl3) δ: 3.05 (3H, d, J = 4.6 Hz), 6.14 (1H, brs), 7.42 (1H, d, J = 8.3 Hz), 8.09 (1H, dd, J = 2.4, 8.3 Hz), 8.72 (1H, d, J = 2.4 Hz).

References

[1] Patent: US2010/280013, 2010, A1. Location in patent: Page/Page column 13
[2] Patent: US2010/48610, 2010, A1. Location in patent: Page/Page column 22
[3] Patent: US2009/69300, 2009, A1. Location in patent: Page/Page column 28
[4] Patent: WO2005/97778, 2005, A1. Location in patent: Page/Page column 26

6-CHLORO-N-METHYL-NICOTINAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-CHLORO-N-METHYL-NICOTINAMIDE Suppliers

China 69 Germany 1 India 1 Ukraine 1 United Kingdom 2 United States 13 Global 87
Yangzhou Siyu Chemical Co.,Ltd.
Tel
0514-87325867
Fax
0086-514-87325867
Email
sales@siyuchem.com
Country
China
ProdList
370
Advantage
55
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
5000
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
Wuhan Kaymke Chemical Co., Ltd.,
Tel
027-027-87342388 18086026008
Fax
027-87342388
Email
sales@kaymke.com
Country
China
ProdList
3732
Advantage
55
Nanjing Chempioneer Pharmaceutical Co., Ltd.
Tel
18068075658
Fax
-
Email
sales@chempioneer.com
Country
China
ProdList
1811
Advantage
58
Nantong Zandery Biotechnology Co., Ltd.
Tel
0513-87582998 13912206938
Fax
+86 (513) 87581996
Email
xiaofeizhu@vip.163.com
Country
China
ProdList
252
Advantage
55
Zhengzhou kangnuochenrui Chemical Technology Co.,Ltd
Tel
18210788515
Fax
18210788515
Email
zhuzixin999@163.c0m
Country
China
ProdList
2998
Advantage
55
Yancheng KangdiSen Pharmaceutical Co., Ltd.
Tel
13812573443
Fax
-
Email
tongbenwan22@163.com
Country
China
ProdList
1980
Advantage
55
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View Lastest Price from 6-CHLORO-N-METHYL-NICOTINAMIDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
6-Chloro-N-methylnicotinamide 54189-82-1
Price
US $3.90-5.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-06-13
Career Henan Chemical Co
Product
6-CHLORO-N-METHYL-NICOTINAMIDE 54189-82-1
Price
US $3.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-04

54189-82-1, 6-CHLORO-N-METHYL-NICOTINAMIDERelated Search:

2-Chloro-N-methyl-nicotinamide 1-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-3-(2,5-DICHLOROPHENYL)IMIDAZOLIDINE-2,4,5-TRIONE 6-chloro-N-(4-methylphenyl)pyridine-3-carboxamide N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-(2,5-DICHLOROPHENYL)UREA N3-PHENYL-6-CHLORONICOTINAMIDE 1-[4-(4-CHLOROPHENOXY)PHENYL]-3-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]IMIDAZOLIDINE-2,4,5-TRIONE N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-(3,4-DICHLOROPHENYL)UREA N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-(2,4-DICHLOROPHENYL)UREA 1-CHLORO-N-(4-CHLOROPHENYL)-N-METHYL-4-ISOQUINOLINECARBOXAMIDE N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-(2,6-DICHLOROPHENYL)UREA N-[4-(4-CHLOROPHENOXY)PHENYL]-N'-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]UREA 1-CHLORO-N-(4-CHLOROPHENYL)-4-ISOQUINOLINECARBOXAMIDE N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-(3,5-DICHLOROPHENYL)UREA N-(4-CHLOROPHENYL)-N'-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]UREA N3-(4-CHLOROPHENYL)-6-CHLORONICOTINAMIDE N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-PIPERIDINOUREA N3-(2,4-DICHLOROBENZYL)-N3-PROPYL-6-CHLORO-4-(TRIFLUOROMETHYL)NICOTINAMIDE N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-MORPHOLINOUREA

  • 6-CHLORO-N-METHYL-NICOTINAMIDE
  • 6-chloro-nicotinic acid N-MethylaMide
  • 3-Pyridinecarboxamide, 6-chloro-N-methyl-
  • 54189-82-1