ChemicalBook > CAS DataBase List > SR 142948

SR 142948

Product Name
SR 142948
CAS No.
184162-64-9
Chemical Name
SR 142948
Synonyms
SR 142948;LWULHXVBLMWCHO-UHFFFAOYSA-N;inhibit,HT 29,Neurotensin Receptor,SR 142948,CHO cells,SR142948,SR-142948,dopamine,neurotensin,Inhibitor,psychotic disorders;2-[(5-(2,6-DIMETHOXY-PHENYL)-1-(4-[(3-DIMETHYLAMINO-PROPYL)-METHYL-CARBAMOYL]-2-ISOPROPYL-PHENYL)-1H-PYRAZOLE-3-CARBONYL)-AMINO]-ADAMANTANE-2-CARBOXYLIC ACID;2-[[[5-(2,6-DIMETHOXYPHENYL)-1-[4-[[[3-(DIMETHYLAMINO)PROPYL]METHYLAMINO]CARBONYL]-2-(1-METHYLETHYL)PHENYL]-1H-PYRAZOL-3-YL]CARBONYL]AMINO]-TRICYCLO[3.3.1.13,7]DECANE-2-CARBOXYLIC ACID;2-[[[5-(2,6-DIMETHOXYPHENYL)-1-[4-[[[3-(DIMETHYLAMINO)PROPYL]METHYLAMINO]CARBONYL]-2-(1-METHYLETHYL)PHENYL]-1H-PYRAZOL-3-YL]CARBONYL]AMINO]-TRICYCLO[3.3.1.13,7]DECANE-2-CARBOXYLIC ACID;TRICYCLO[3.3.1.13,7]DECANE-2-CARBOXYLIC ACID, 2-[[[5-(2,6-DIMETHOXYPHENYL)-1-[4-[[[3-(DIMETHYLAMINO)PROPYL]METHYLAMINO]CARBONYL]-2-(1-METHYLETHYL)PHENYL]-1H-PYRAZOL-3-YL]CARBONYL]AMINO]-
CBNumber
CB9787670
Molecular Formula
C39H51N5O6
Formula Weight
685.85214
MOL File
184162-64-9.mol
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SR 142948 Property

Boiling point:
824.7±65.0 °C(Predicted)
Density 
1.29±0.1 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
Soluble to 75 mM in DMSO and to 25 mM in water
form 
Powder
pka
3.28±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23911
Product name
SR 142948
Purity
≥98%
Packaging
1mg
Price
$75
Updated
2021/12/16
Cayman Chemical
Product number
23911
Product name
SR 142948
Purity
≥98%
Packaging
5mg
Price
$175
Updated
2021/12/16
Cayman Chemical
Product number
23911
Product name
SR 142948
Purity
≥98%
Packaging
10mg
Price
$250
Updated
2021/12/16
Tocris
Product number
2309
Product name
SR142948
Purity
≥97%(HPLC)
Packaging
10
Price
$298
Updated
2021/12/16
Tocris
Product number
2309
Product name
SR142948
Purity
≥97%(HPLC)
Packaging
1
Price
$141
Updated
2021/12/16
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SR 142948 Chemical Properties,Usage,Production

Uses

SR 142948 is an antagonist of NT1/NT2 receptors inhibiting bile acid secretion. Neurotensin receptor antagonist.

Definition

ChEBI: 2-[[[5-(2,6-dimethoxyphenyl)-1-[4-[[3-(dimethylamino)propyl-methylamino]-oxomethyl]-2-propan-2-ylphenyl]-3-pyrazolyl]-oxomethyl]amino]-2-adamantanecarboxylic acid is a N-acyl-amino acid.

Biological Activity

Potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC 50 = 0.32 - 3.96 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo .

storage

Store at +4°C

SR 142948 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR 142948 Suppliers

Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

184162-64-9, SR 142948Related Search:


  • TRICYCLO[3.3.1.13,7]DECANE-2-CARBOXYLIC ACID, 2-[[[5-(2,6-DIMETHOXYPHENYL)-1-[4-[[[3-(DIMETHYLAMINO)PROPYL]METHYLAMINO]CARBONYL]-2-(1-METHYLETHYL)PHENYL]-1H-PYRAZOL-3-YL]CARBONYL]AMINO]-
  • SR 142948
  • 2-[(5-(2,6-DIMETHOXY-PHENYL)-1-(4-[(3-DIMETHYLAMINO-PROPYL)-METHYL-CARBAMOYL]-2-ISOPROPYL-PHENYL)-1H-PYRAZOLE-3-CARBONYL)-AMINO]-ADAMANTANE-2-CARBOXYLIC ACID
  • LWULHXVBLMWCHO-UHFFFAOYSA-N
  • 2-[[[5-(2,6-DIMETHOXYPHENYL)-1-[4-[[[3-(DIMETHYLAMINO)PROPYL]METHYLAMINO]CARBONYL]-2-(1-METHYLETHYL)PHENYL]-1H-PYRAZOL-3-YL]CARBONYL]AMINO]-TRICYCLO[3.3.1.13,7]DECANE-2-CARBOXYLIC ACID
  • inhibit,HT 29,Neurotensin Receptor,SR 142948,CHO cells,SR142948,SR-142948,dopamine,neurotensin,Inhibitor,psychotic disorders
  • 2-[[[5-(2,6-DIMETHOXYPHENYL)-1-[4-[[[3-(DIMETHYLAMINO)PROPYL]METHYLAMINO]CARBONYL]-2-(1-METHYLETHYL)PHENYL]-1H-PYRAZOL-3-YL]CARBONYL]AMINO]-TRICYCLO[3.3.1.13,7]DECANE-2-CARBOXYLIC ACID
  • 184162-64-9
  • C39H51N5O6