2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
- Product Name
- 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
- CAS No.
- 65836-72-8
- Chemical Name
- 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
- Synonyms
- DKM 2-93;Brn 2857211;CHEMBRDG-BB 9070724;N-(Dimethoxy-3,4 benzyl)-chloroacetamide;2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE;N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french];2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide;2-chloro-N-[(3,4-dimethoxyphenyl)methyl]ethanamide;Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-;2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE)
- CBNumber
- CB9796621
- Molecular Formula
- C11H14ClNO3
- Formula Weight
- 243.69
- MOL File
- 65836-72-8.mol
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Property
- Melting point:
- 116-118 °C(Solv: carbon tetrachloride (56-23-5))
- Boiling point:
- 425.7±45.0 °C(Predicted)
- Density
- 1.194±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 150 mg/mL (615.54 mM)
- form
- Solid
- pka
- 13.42±0.46(Predicted)
- color
- White to light yellow
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H331Toxic if inhaled
H341Suspected of causing genetic defects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-6514
- Product name
- DKM2-93
- Purity
- 98.76%
- Packaging
- 100mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- FC114033
- Product name
- 2-Chloro-N-(3,4-dimethoxybenzyl)acetamide
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 029584
- Product name
- 2-Chloro-N-(3,4-dimethoxybenzyl)acetamide
- Packaging
- 500mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- CS-6514
- Product name
- DKM2-93
- Purity
- 98.76%
- Packaging
- 200mg
- Price
- $144
- Updated
- 2021/12/16
- Product number
- FC114033
- Product name
- 2-Chloro-N-(3,4-dimethoxybenzyl)acetamide
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Chemical Properties,Usage,Production
Biological Activity
DKM 2-93 is a relatively selective UBA5 inhibitor with IC50 value of 430 μM.
in vitro
Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC 50 s of 90 and 30 μM, respectively.
in vivo
DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.
target
IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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