2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE

ChemicalBook > CAS DataBase List > 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE

2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE

Product Name: 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
CAS No.: 65836-72-8
Chemical Name: 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
Synonyms: DKM 2-93;Brn 2857211;CHEMBRDG-BB 9070724;N-(Dimethoxy-3,4 benzyl)-chloroacetamide;2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE;N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french];2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide;2-chloro-N-[(3,4-dimethoxyphenyl)methyl]ethanamide;Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-;2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE)
CBNumber: CB9796621
Molecular Formula: C11H14ClNO3
Formula Weight: 243.69
MOL File: 65836-72-8.mol

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2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Property

Melting point:: 116-118 °C(Solv: carbon tetrachloride (56-23-5))
Boiling point:: 425.7±45.0 °C(Predicted)
Density: 1.194±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 150 mg/mL (615.54 mM)
form: Solid
pka: 13.42±0.46(Predicted)
color: White to light yellow

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6514
Product name: DKM2-93
Purity: 98.76%
Packaging: 100mg
Price: $84
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC114033
Product name: 2-Chloro-N-(3,4-dimethoxybenzyl)acetamide
Packaging: 250mg
Price: $85
Updated: 2021/12/16

Matrix Scientific

Product number: 029584
Product name: 2-Chloro-N-(3,4-dimethoxybenzyl)acetamide
Packaging: 500mg
Price: $95
Updated: 2021/12/16

ChemScene

Product number: CS-6514
Product name: DKM2-93
Purity: 98.76%
Packaging: 200mg
Price: $144
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC114033
Product name: 2-Chloro-N-(3,4-dimethoxybenzyl)acetamide
Packaging: 500mg
Price: $150
Updated: 2021/12/16

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2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Chemical Properties,Usage,Production

Biological Activity

DKM 2-93 is a relatively selective UBA5 inhibitor with IC50 value of 430 μM.

in vitro

Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC ₅₀ s of 90 and 30 μM, respectively.

in vivo

DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.

target

IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)

2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Suppliers

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65836-72-8, 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDERelated Search:

2-CHLORO-N-[1-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)ETHYL]ACETAMIDE 1-(CHLOROACETYL)-2-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)PYRROLIDINE 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE 2-CHLORO-N-[1-(3,4-DIPROPOXYPHENYL)ETHYL]ACETAMIDE 2-CHLORO-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHYL)-N-ETHYLACETAMIDE 2-(CHLOROACETYL)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE 1-(CHLOROACETYL)-5-(3,4-DIMETHOXYPHENYL)-3-THIEN-2-YL-4,5-DIHYDRO-1H-PYRAZOLE 1-(CHLOROACETYL)-2-(3,4-DIHYDRO-2H-1,5-BENZODIOXEPIN-7-YL)PYRROLIDINE 2-CHLORO-1-[1-(3,4-DIETHOXY-BENZYL)-6,7-DIETHOXY-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL]-ETHANONE 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)PROPANAMIDE 2-CHLORO-N-[1-(3,4-DIHYDRO-2H-1,5-BENZODIOXEPIN-7-YL)-2-METHYLPROPYL]ACETAMIDE 2-CHLORO-N-[4-(DIFLUOROMETHOXY)-3-METHOXYBENZYL]-N-METHYLACETAMIDE 2-CHLORO-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHYL)-N-METHYLACETAMIDE 2-CHLORO-N-(5,6-DIMETHOXY-3-OXO-INDAN-1-YL)-ACETAMIDE 2-CHLORO-N-METHYL-N-(2,3,4-TRIMETHOXYBENZYL)ACETAMIDE 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)-N-METHYLACETAMIDE 2-CHLORO-1-(6,7-DIMETHOXY-1-PHENYL-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-ETHANONE N-[4-(BENZYLOXY)-3-METHOXYBENZYL]-2-CHLOROACETAMIDE

2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE

CHEMBRDG-BB 9070724

2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide

Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-

Brn 2857211

N-(Dimethoxy-3,4 benzyl)-chloroacetamide

N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french]

2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE)

2-chloro-N-[(3,4-dimethoxyphenyl)methyl]ethanamide

DKM 2-93

E1 activating enzyme,Ubiquitin activating enzyme,E1/E2/E3 Enzyme,Inhibitor,DKM 2-93,Ubiquitin conjugating enzyme,Ubiquitin ligase,inhibit,E3 ligating enzyme,E2 conjugating enzyme,DKM 293,DKM 2 93

65836-72-8