ChemicalBook > CAS DataBase List > BAY-1797

BAY-1797

Product Name
BAY-1797
CAS No.
2055602-83-8
Chemical Name
BAY-1797
Synonyms
BAY-1797;BAY-1797, 10 mM in DMSO;Benzeneacetamide, N-[3-(aminosulfonyl)-4-(3-chlorophenoxy)phenyl]-;paw,ion,inhibit,anti-inflammatory,CFA,Complete,P2XRs,BAY-1797,Freund’s,selective,channel,P2X Receptor,inflamed,Inhibitor,BAY1797,Adjuvant,BAY 1797,P2X,anti-nociceptive
CBNumber
CB98022694
Molecular Formula
C20H17ClN2O4S
Formula Weight
416.88
MOL File
2055602-83-8.mol
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BAY-1797 Property

Density 
1.414±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (>25 mg/ml)
pka
9.84±0.60(Predicted)
form 
solid
color 
Pale brown
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey
CSJYMAFXYMYNCK-UHFFFAOYSA-N
SMILES
ClC1=CC=CC(OC2=C(C=C(NC(CC3=CC=CC=C3)=O)C=C2)S(=O)(N)=O)=C1
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2817
Product name
BAY-1797
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$111
Updated
2026/03/19
Sigma-Aldrich
Product number
SML2817
Product name
BAY-1797
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$356
Updated
2026/03/19
ChemScene
Product number
CS-0109406
Product name
BAY-1797
Purity
98.66%
Packaging
50mg
Price
$695
Updated
2021/12/16
ChemScene
Product number
CS-0109406
Product name
BAY-1797
Purity
98.66%
Packaging
100mg
Price
$1250
Updated
2021/12/16
ChemScene
Product number
CS-0109406
Product name
BAY-1797
Purity
98.66%
Packaging
5mg
Price
$205
Updated
2021/12/16
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BAY-1797 Chemical Properties,Usage,Production

Description

BAY-1797 (2055602-83-8) is a selective P2X4 receptor antagonist (IC50 = 211 nM HEK cellular assay; P2X4 calcium influx based assays – hIC50 = 108 nM, mIC50 = 112 nM, rIC50 = 233 nM).1 Displayed antinociceptive and anti-inflammatory effects in mouse CFA inflammatory pain models.

Uses

BAY-1797 is a potent, orally active, and selective P2X4 antagonist, with an IC50 of 211 nM against human P2X4. BAY-1797 displays no or very weak activity on the other P2X ion channels. BAY-1797 shows anti-nociceptive and anti-inflammatory effects[1].

in vivo

BAY-1797 (12.5-50 mg/kg; p.o.) shows a significant induction of PGE2 levels in the inflamed paw in the mouse Complete Freund’s Adjuvant (CFA) inflammatory pain model[1].
BAY-1797 (50 mg/kg; once daily for multiple p.o. administrations) induces a significant reduction of the ipsilateral paw load 24 and 48 h after CFA injection[1].
BAY-1797 treatment shows the AUCnorm, Vss and t1/2 are 1.06 kg h/L, 3.67 L/kg and 2.64 hours, respectively[1].

Animal Model:Female adult C57BL/6N mice (CFA inflammatory pain model)[1]
Dosage:12.5, 25, 50 mg/kg
Administration:p.o.; once
Result:Dose-dependently reduced PGE2 concentration in inflamed paw.
Animal Model:Rat male Wistar[1]
Dosage:1 mg/kg
Administration:i.v. (Pharmacokinetic Analysis)
Result:The AUCnorm, Vss and t1/2 were 1.06 kg h/L, 3.67 L/kg and 2.64 hours, respectively.

IC 50

P2X4 Receptor

storage

Store at -20°C

References

[1] STEFAN WERNER*. Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile[J]. Journal of Medicinal Chemistry, 2019, 62 24: 11194-11217. DOI:10.1021/acs.jmedchem.9b01304

BAY-1797 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY-1797 Suppliers

China 38 United States 4 Global 42
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070 13770331960
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16027
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Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4817
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9505
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Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29661
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68
Jilin Province Woda Biotechnology Co., Ltd.
Tel
13504435624
Email
1927928688@qq.com
Country
China
ProdList
1634
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58
Zhengzhou Alfa Chemical Co.,Ltd
Tel
+8618530059196
Email
sale04@alfachem.cn
Country
China
ProdList
9548
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
Shanghai Dongyang Biotechnology Co., Ltd.
Tel
0512-0512-13601744364 13601744364
Email
chemsharker@126.com
Country
China
ProdList
1133
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58

2055602-83-8, BAY-1797Related Search:

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  • BAY-1797
  • paw,ion,inhibit,anti-inflammatory,CFA,Complete,P2XRs,BAY-1797,Freund’s,selective,channel,P2X Receptor,inflamed,Inhibitor,BAY1797,Adjuvant,BAY 1797,P2X,anti-nociceptive
  • Benzeneacetamide, N-[3-(aminosulfonyl)-4-(3-chlorophenoxy)phenyl]-
  • BAY-1797, 10 mM in DMSO
  • 2055602-83-8