ChemicalBook > CAS DataBase List > S14-95

S14-95

Product Name
S14-95
CAS No.
419532-92-6
Chemical Name
S14-95
Synonyms
S14-95;S14-95, JAK/STAT pathway inhibitor;2H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-11-one, 3-(acetyloxy)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-4,4,6a,12b-tetramethyl-9-phenyl-, (3S,4aR,6aR,12aR,12bS)-
CBNumber
CB9807781
Molecular Formula
C28H34O5
Formula Weight
450.57
MOL File
419532-92-6.mol
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S14-95 Property

Boiling point:
559.0±50.0 °C(Predicted)
Density 
1.20±0.1 g/cm3(Predicted)
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Hazard and Precautionary Statements (GHS)

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S14-95 Chemical Properties,Usage,Production

Uses

Phenylpyropene C (S14-95), a JAK/STAT pathway inhibitor, can inhibit IFN-γ mediated expression of the reporter gene (IC50=5.4~10.8 μM). Phenylpyropene C also is an inhibitor of acyl-CoA, with an IC50 of 16.0 μM[1][2].

IC 50

ACAT: 16.0 μM (IC50)

References

[1] Rho MC, et, al. Phenylpyropene C, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Penicillium griseofulvum F1959. J Antibiot (Tokyo). 2002 Feb;55(2):211-4. DOI:10.7164/antibiotics.55.211
[2] Erkel G, et, al. S14-95, a novel inhibitor of the JAK/STAT pathway from a Penicillium species. J Antibiot (Tokyo). 2003 Apr;56(4):337-43. DOI:10.7164/antibiotics.56.337

S14-95 Preparation Products And Raw materials

Raw materials

Preparation Products

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S14-95 Suppliers

CHINA 22 Switzerland 1 United States 4 Global 27
Zhejiang Huida Biotech Co., LTD
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419532-92-6, S14-95Related Search:


  • S14-95
  • 2H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-11-one, 3-(acetyloxy)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-4,4,6a,12b-tetramethyl-9-phenyl-, (3S,4aR,6aR,12aR,12bS)-
  • S14-95, JAK/STAT pathway inhibitor
  • 419532-92-6