ChemicalBook > CAS DataBase List > S14-95
S14-95
- Product Name
- S14-95
- CAS No.
- 419532-92-6
- Chemical Name
- S14-95
- Synonyms
- S14-95;S14-95, JAK/STAT pathway inhibitor;2H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-11-one, 3-(acetyloxy)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-4,4,6a,12b-tetramethyl-9-phenyl-, (3S,4aR,6aR,12aR,12bS)-
- CBNumber
- CB9807781
- Molecular Formula
- C28H34O5
- Formula Weight
- 450.57
- MOL File
- 419532-92-6.mol
More
Less
S14-95 Property
- Boiling point:
- 559.0±50.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
More
Less
S14-95 Chemical Properties,Usage,Production
Uses
Phenylpyropene C (S14-95), a JAK/STAT pathway inhibitor, can inhibit IFN-γ mediated expression of the reporter gene (IC50=5.4~10.8 μM). Phenylpyropene C also is an inhibitor of acyl-CoA, with an IC50 of 16.0 μM[1][2].
IC 50
ACAT: 16.0 μM (IC50)
References
[1] Rho MC, et, al. Phenylpyropene C, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Penicillium griseofulvum F1959. J Antibiot (Tokyo). 2002 Feb;55(2):211-4. DOI:10.7164/antibiotics.55.211
[2] Erkel G, et, al. S14-95, a novel inhibitor of the JAK/STAT pathway from a Penicillium species. J Antibiot (Tokyo). 2003 Apr;56(4):337-43. DOI:10.7164/antibiotics.56.337
S14-95 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
S14-95 Suppliers
- Tel
- --
- Fax
- --
- alexis-ch@alexis-corp.ch
- Country
- Switzerland
- ProdList
- 3599
- Advantage
- 74