Losatuxizumab

Product Name: Losatuxizumab
CAS No.: 1801544-27-3
Chemical Name: Losatuxizumab
Synonyms: Losatuxizumab;Losatuxizumab (anti-EGFR);Research Grade Losatuxizumab;Research Grade Losatuxizumab(DHB86913)
CBNumber: CB98081019
Formula Weight: 0
MOL File: Mol file

More

Less

Losatuxizumab Property

form: Liquid
color: Colorless to light yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

Losatuxizumab Chemical Properties,Usage,Production

Uses

Losatuxizumab is an anti-EGFR monoclonal antibody. Losatuxizumab binds to EGFR with EC50s of 0.96 nM for EGFR wild-type, 0.09 nM for EGFRC271A,C283A, 0.12 nM for EGFRvIII, 0.66 nM for EGFR1-501. Losatuxizumab can be used for research of EGFR-expressing cancers[1][2].

in vivo

Lorigerlimab has antitumor activities in various wild-type EGFR-expressing squamous cell carcinoma xenograft model^[1].
Lorigerlimab (40 mg/kg, i.p.) significantly inhibits growth of U87MGde2-7 tumor in mice^[1].
Lorigerlimab (10 and 40 mg/kg, i.p.) prolongs survival and reduces levels of pEGFR in PDX GBM model (SN0207 tumor)^[1].

Animal Model:	PDX GBM model (SN0207 tumor)^[1]
Dosage:	40 mg/kg
Administration:	i.p.
Result:	Prolonged survival rate, and reduced levels of pEGFR in tumor.

References

[1] Reilly EB, et al. Characterization of ABT-806, a Humanized Tumor-Specific Anti-EGFR Monoclonal Antibody. Mol Cancer Ther. 2015 May;14(5):1141-51. DOI:10.1158/1535-7163.MCT-14-0820
[2] Phillips AC, et al. ABT-414, an Antibody-Drug Conjugate Targeting a Tumor-Selective EGFR Epitope. Mol Cancer Ther. 2016 Apr;15(4):661-9. DOI:10.1158/1535-7163.MCT-15-0901

Losatuxizumab Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Losatuxizumab Suppliers

China 13 Global 13

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Wuhan Chemstan Biotechnology Co., Ltd.

Tel: 027-65317797 15926423062
Fax: QQ：422450190
Email: 422450190@qq.com
Country: China
ProdList: 10308
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Biolab Reagents

Tel: 027-65279366 18108604356
Email: products@biolabreagent.com
Country: China
ProdList: 9868
Advantage: 58

Wuhan Jingkangen Biomedical Technology Co., Ltd

Tel: 13720134139 086-15871494362 13720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 6762
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

Changsha Fuzhen Biotechnology Co.，LTD

Tel: 0731-13823398 15111215862
Email: 313359644@qq.com
Country: China
ProdList: 4161
Advantage: 58

Atagenix Laboratories

Tel: 027-87008169 17762441161
Email: info@atagenix.com
Country: China
ProdList: 10001
Advantage: 58

AntibodySystem Laboratories SAS

Tel: 33175446423
Email: support@antibodysystem.com
Country: China
ProdList: 6739
Advantage: 58

1801544-27-3, LosatuxizumabRelated Search:

Talizumab Tucotuzumab Celmoleukin Trastuzumab Amatuximab Daxdilimab Immunoglobulin G4,anti-(human integrin R4) (human-mouse monoclonal AN100226 c4-chain),disulfide with human-mouse monoclonal AN100226 light chain,dimer Sifalimumab Tiragolumab Pritumumab Enavatuzumab

Losatuxizumab

Research Grade Losatuxizumab(DHB86913)

Research Grade Losatuxizumab

Losatuxizumab (anti-EGFR)

1801544-27-3