9H-Carbazole-3-carboxylic acid, 1-hydroxy-, methyl ester
- Product Name
- 9H-Carbazole-3-carboxylic acid, 1-hydroxy-, methyl ester
- CAS No.
- 182261-83-2
- Chemical Name
- 9H-Carbazole-3-carboxylic acid, 1-hydroxy-, methyl ester
- Synonyms
- Clausine E, 10 mM in DMSO;9H-Carbazole-3-carboxylic acid, 1-hydroxy-, methyl ester
- CBNumber
- CB98081756
- Molecular Formula
- C14H11NO3
- Formula Weight
- 241.24
- MOL File
- 182261-83-2.mol
9H-Carbazole-3-carboxylic acid, 1-hydroxy-, methyl ester Property
- Melting point:
- 215-216.5 °C
- Boiling point:
- 512.7±30.0 °C(Predicted)
- Density
- 1.400±0.06 g/cm3(Predicted)
- pka
- 9.34±0.30(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CFN91823
- Product name
- ClausineE
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $318
- Updated
- 2021/12/16
9H-Carbazole-3-carboxylic acid, 1-hydroxy-, methyl ester Chemical Properties,Usage,Production
Uses
Clausine E, is a alkaloid which can be isolated from Clausena excavata, is a inhibitor of fat mass and obesity-associated protein (FTO) demethylase. Clausine E shows inhibitory activities against proliferation of synoviocytes and cancer cells.
Definition
ChEBI: Clausine E is a member of carbazoles. It has a role as a metabolite.
References
[1] Wang Y, Li J, Han X, et al. Identification of Clausine E as an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity. J Mol Recognit. 2019;32(10):e2800. DOI:10.1002/jmr.2800
[2] Guo JM, Yu XM, Jiang B, et al. Zhongguo Zhong Yao Za Zhi. 2021;46(17):4438-4445. DOI:10.19540/j.cnki.cjcmm.20210429.203
[3] Liger F, Popowycz F, Besson T, Picot L, Galmarini CM, Joseph B. Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres. Bioorg Med Chem. 2007;15(16):5615-5619. DOI:10.1016/j.bmc.2007.05.033
9H-Carbazole-3-carboxylic acid, 1-hydroxy-, methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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