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1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-

Product Name
1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-
CAS No.
1256349-48-0
Chemical Name
1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-
Synonyms
Chiauranib;ibcasertib;Chiauranib (CS2164);Chiauranib/1256349-48-0;Chiauranib, 10 mM in DMSO;N-(2-Aminophenyl)-6-((7-methoxyquinolin-4-yl)oxy)-1-naphthamide;N-(2-Aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-1-naphthalenecarboxamide;1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-;CSF-1R,VEGFR2,CSF1R,Vascular endothelial growth factor receptor,VEGFR3,anti-angiogenesis,CD117,Aurora Kinase,c-Kit,CS-2164,CSF-1 receptor,Chiauranib,colony stimulating factor 1 receptor,PDGFRα,PDGFR,Aurora-B,anticancer,inhibit,SCFR,Inhibitor,VEGFR,Platelet-derived growth factor receptor,CS 2164,VEGFR1,c-Fms
CBNumber
CB98119659
Molecular Formula
C27H21N3O3
Formula Weight
435.47
MOL File
1256349-48-0.mol
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1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]- Property

Boiling point:
604.6±50.0 °C(Predicted)
Density 
1.333±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
DMSO : 62.5 mg/mL (143.52 mM; Need ultrasonic)
pka
12.77±0.70(Predicted)
form 
Solid
color 
White to light brown
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Hazard and Precautionary Statements (GHS)

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1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]- Chemical Properties,Usage,Production

Uses

Chiauranib (CS2164) is an orally active multi-target inhibitor against tumor angiogenesis. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF-1R, with IC50 values ranging from 1-9 nM. Chiauranib has strongly anticancer effects[1].

in vivo

Chiauranib (CS2164; 0.5-40 mg/kg; oral administration; once daily; for 33 days or 43 days) treatment induces remarkable regression or complete inhibition of tumor growth at well-tolerated oral doses in several human tumor xenograft models. Chiauranib exhibits broad and potent in vivo anti-tumor activities[1].

Animal Model:Female BALB/c athymic (nu+/nu+) mice (6-week old) bearing HCT-8, SMMC-7721, MGC‐803 or A549 cells[1]
Dosage:2.5 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg, 40 mg/kg
Administration:Oral administration; once daily; for 33 days or 43 days
Result:Induced remarkable regression or complete inhibition of tumor growth in several human tumor xenograft models.

IC 50

Flt-1: 8 nM (IC50); KDR: 7 nM (IC50); Flt-4: 9 nM (IC50); PDGFRα: 1 nM (IC50); c-Kit: 4 nM (IC50); Aurora B: 9 nM (IC50); PDGFRβ: 93 nM (IC50); CSF-1R: 7 nM (IC50)

References

[1] You Zhou, et al. CS2164, a novel multi-target inhibitor against tumor angiogenesis, mitosis and chronic inflammation with anti-tumor potency. Cancer Sci. 2017 Mar;108(3):469-477. DOI:10.1111/cas.13141

1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]- Suppliers

China 34 United States 3 Global 37
Nanjing Chemlin Chemical Co., Ltd
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18149758185
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Shanghai Chaolan Chemical Technology Center
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Aikon International Limited
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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Shanghai Dongyang Biotechnology Co., Ltd.
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1256349-48-0, 1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-Related Search:


  • 1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-
  • N-(2-Aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-1-naphthalenecarboxamide
  • Chiauranib
  • Chiauranib (CS2164)
  • ibcasertib
  • CSF-1R,VEGFR2,CSF1R,Vascular endothelial growth factor receptor,VEGFR3,anti-angiogenesis,CD117,Aurora Kinase,c-Kit,CS-2164,CSF-1 receptor,Chiauranib,colony stimulating factor 1 receptor,PDGFRα,PDGFR,Aurora-B,anticancer,inhibit,SCFR,Inhibitor,VEGFR,Platelet-derived growth factor receptor,CS 2164,VEGFR1,c-Fms
  • N-(2-Aminophenyl)-6-((7-methoxyquinolin-4-yl)oxy)-1-naphthamide
  • Chiauranib, 10 mM in DMSO
  • Chiauranib/1256349-48-0
  • 1256349-48-0