ChemicalBook > CAS DataBase List > Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-
Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-
- Product Name
- Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-
- CAS No.
- 757192-67-9
- Chemical Name
- Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-
- Synonyms
- EN106;2-Chloro-N-(2-cyanoethyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetamide;Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-
- CBNumber
- CB98291959
- Molecular Formula
- C13H13ClN2O3
- Formula Weight
- 280.71
- MOL File
- 757192-67-9.mol
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Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)- Property
- Boiling point:
- 489.1±45.0 °C(Predicted)
- Density
- 1.351±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 250 mg/mL (890.60 mM; Need ultrasonic)
- pka
- 0.42±0.20(Predicted)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML3516
- Product name
- EN106
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $63.27
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SML3516
- Product name
- EN106
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $268
- Updated
- 2025/07/31
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Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)- Chemical Properties,Usage,Production
Uses
EN106 is a potent inhibitor of FEMIB. EN106 is a cysteine-reactive covalent ligand. EN106 disrupts recognition of the key reductive stress substrate of FEM1B, FNIP1[1].
Biological Activity
EN106 is a cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B th at binds to C186 of FEM1B. EN106 disrupts FEM1B interactions with the FNIP1 degron and inhibits CUL2FEM1B-dependent ubiquitylation without detectable off-target effects. A modified EN106 bifunctional analog (PROTAC) recruits FEM1B and induces targeted BRD4 and BCR-ABL/c-ABL degradation.
References
[1] Henning NJ, et al. Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications. J Am Chem Soc. 2022;144(2):701-708. DOI:10.1021/jacs.1c03980
Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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