10-DEBC HYDROCHLORIDE
- Product Name
- 10-DEBC HYDROCHLORIDE
- CAS No.
- 201788-90-1
- Chemical Name
- 10-DEBC HYDROCHLORIDE
- Synonyms
- aktX;CCG-206734;CCG 206734;10-DEBC HYDROCHLORIDE;10H-Phenoxazine-10-butanaMine,2-chloro-N,N-diethyl-;10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazinehydrochloride
- CBNumber
- CB9838323
- Molecular Formula
- C20H25ClN2O
- Formula Weight
- 344.88
- MOL File
- 201788-90-1.mol
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10-DEBC HYDROCHLORIDE Property
- Melting point:
- >178°C (dec.)
- Boiling point:
- 465.1±45.0 °C(Predicted)
- Density
- 1.134±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at +4°C
- form
- White crystalline solid.
- pka
- 10.46±0.25(Predicted)
- color
- White to Off-White
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N-Bromosuccinimide Price
Tocris
- Product number
- 2558
- Product name
- 10-DEBChydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $151
- Updated
- 2021/12/16
Tocris
- Product number
- 2558
- Product name
- 10-DEBChydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $634
- Updated
- 2021/12/16
Usbiological
- Product number
- 254339
- Product name
- 10-DEBC hydrochloride
- Packaging
- 10mg
- Price
- $409
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- INB0001188
- Product name
- 10-DEBC HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $148.05
- Updated
- 2021/12/16
AK Scientific
- Product number
- 9464CW
- Product name
- 10-Debchydrochloride
- Packaging
- 5mg
- Price
- $229
- Updated
- 2021/12/16
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10-DEBC HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
10-DEBC Hydrochloride is an AKT inhibitor. Study shows that efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine.
Biological Activity
Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μ M), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC 50 ~ 2-6 μ M) and induces apoptosis in rhabdomyosarcoma cells.
10-DEBC HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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