ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE
- Product Name
- ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE
- CAS No.
- 73956-17-9
- Chemical Name
- ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE
- Synonyms
- ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE;5-ethyl-2-formyl-4-thiazolecarboxylate;2-FORMYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;4-Thiazolecarboxylic acid, 2-formyl-, ethyl ester;4-Thiazolecarboxylicacid,2-formyl-,ethylester(9CI)
- CBNumber
- CB9839320
- Molecular Formula
- C7H7NO3S
- Formula Weight
- 185.2
- MOL File
- 73956-17-9.mol
ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE Property
- Melting point:
- 64.3-65.6 °C(Solv: ligroine (8032-32-4))
- Boiling point:
- 311.6±34.0 °C(Predicted)
- Density
- 1.340±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.90±0.10(Predicted)
- Appearance
- White to light yellow Solid
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E918383
- Product name
- Ethyl2-Formylthiazole-4-carboxylate
- Packaging
- 100mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- P000145308
- Product name
- Ethyl 2-formylthiazole-4-carboxylate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $11
- Updated
- 2021/12/16
- Product number
- P000145308
- Product name
- Ethyl 2-formylthiazole-4-carboxylate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $19
- Updated
- 2021/12/16
- Product number
- P000145308
- Product name
- Ethyl 2-formylthiazole-4-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $37
- Updated
- 2021/12/16
- Product number
- CS-0158741
- Product name
- Ethyl2-formylthiazole-4-carboxylate
- Packaging
- 250mg
- Price
- $110
- Updated
- 2021/12/16
ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
73956-16-8
73956-17-9
General procedure for the synthesis of ethyl 2-formylthiazole-4-carboxylate from ethyl 2-(diethoxymethyl)thiazole-4-carboxylate: (v) Synthesis of ethyl 2-formylthiazole-4-carboxylate (see literature: Inami, K., Shiba, T., Bull. Chem. Soc. Jpn., 1985, 58, 352). Ethyl 2-(diethoxymethyl)thiazole-4-carboxylate (1.34 g, 5.17 mmol; see step (iv) above) was dissolved in acetone (100 mL) followed by addition of 1N HCl solution (12.8 mL). The reaction mixture was refluxed for 45 min, after which the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (40 mL) and washed sequentially with saturated NaHCO3 solution (2 x 40 mL) and brine (2 x 40 mL). The organic phase was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure to give ethyl 2-formylthiazole-4-carboxylate as a light brown solid (0.937 g, 98% yield). Melting point: 65-67°C (literature value: 67-68°C). IR (KBr, cm^-1): 3116 (Ar-H), 2983, 2910, 2814 (CH), 1730 (C=O), 1513 (C=N), 1060 (C-O). 1H NMR (CDCl3): δ 1.47 (3H, t, CH3, J = 8.0 Hz), 4.0%. 8.0 Hz), 4.50 (2H, q, CH2, J = 8.0 Hz), 8.52 (1H, d, Ar-H, J = 1.2 Hz), 10.08 (1H, d, Ar-CHO, J = 1.2 Hz).HRFABMS: measured value m/z 186.0228 (M + H), calculated value for CH7H7NO3S 185.0147.
References
[1] Bulletin of the Chemical Society of Japan, 1985, vol. 58, # 1, p. 352 - 360
[2] Organic and Biomolecular Chemistry, 2009, vol. 7, # 9, p. 1843 - 1850
[3] Patent: WO2008/38018, 2008, A1. Location in patent: Page/Page column 65
[4] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 21, p. 6827 - 6843
[5] Synthetic Communications, 2012, vol. 42, # 14, p. 2098 - 2109
ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE Suppliers
- Tel
- 150-2103-5486 18017383231
- Fax
- qq：2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9342
- Advantage
- 55
- Tel
- 027-027-87342388 18086026008
- Fax
- 027-87342388
- sales@kaymke.com
- Country
- China
- ProdList
- 3731
- Advantage
- 55
- Tel
- 025-66028182 18626450290
- yftan@aikonchem.com
- Country
- China
- ProdList
- 16679
- Advantage
- 50
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 716
- Advantage
- 55
- Tel
- 021-64340559 13651849907;
- Fax
- 021- 64345308
- xinyu_shi@jwypharmlab.com.cn
- Country
- China
- ProdList
- 12000
- Advantage
- 58
- Tel
- 21-33526724 18930996265
- Fax
- +86 21 37023730
- info@carlowchem.com
- Country
- China
- ProdList
- 1969
- Advantage
- 50
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 18621295758
- Fax
- -QQ:1449085402
- 1449085402@qq.com
- Country
- China
- ProdList
- 1724
- Advantage
- 55
- Tel
- 15026866316
- 180642609@qq.com
- Country
- China
- ProdList
- 4967
- Advantage
- 58
- Tel
- 15088289376
- 248775804@qq.com
- Country
- China
- ProdList
- 4995
- Advantage
- 58