ChemicalBook > CAS DataBase List > ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE

ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE

Product Name: ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE
CAS No.: 73956-17-9
Chemical Name: ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE
Synonyms: ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE;5-ethyl-2-formyl-4-thiazolecarboxylate;2-FORMYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;4-Thiazolecarboxylic acid, 2-formyl-, ethyl ester;4-Thiazolecarboxylicacid,2-formyl-,ethylester(9CI)
CBNumber: CB9839320
Molecular Formula: C7H7NO3S
Formula Weight: 185.2
MOL File: 73956-17-9.mol

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ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE Property

Melting point:: 64.3-65.6 °C(Solv: ligroine (8032-32-4))
Boiling point:: 311.6±34.0 °C(Predicted)
Density: 1.340±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.90±0.10(Predicted)
Appearance: White to light yellow Solid

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Safety

HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: E918383
Product name: Ethyl2-Formylthiazole-4-carboxylate
Packaging: 100mg
Price: $220
Updated: 2021/12/16

Ark Pharm

Product number: P000145308
Product name: Ethyl 2-formylthiazole-4-carboxylate
Purity: 95%
Packaging: 100mg
Price: $11
Updated: 2021/12/16

Ark Pharm

Product number: P000145308
Product name: Ethyl 2-formylthiazole-4-carboxylate
Purity: 95%
Packaging: 250mg
Price: $19
Updated: 2021/12/16

Ark Pharm

Product number: P000145308
Product name: Ethyl 2-formylthiazole-4-carboxylate
Purity: 95%
Packaging: 1g
Price: $37
Updated: 2021/12/16

ChemScene

Product number: CS-0158741
Product name: Ethyl2-formylthiazole-4-carboxylate
Packaging: 250mg
Price: $110
Updated: 2021/12/16

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ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

73956-16-8

73956-17-9

General procedure for the synthesis of ethyl 2-formylthiazole-4-carboxylate from ethyl 2-(diethoxymethyl)thiazole-4-carboxylate: (v) Synthesis of ethyl 2-formylthiazole-4-carboxylate (see literature: Inami, K., Shiba, T., Bull. Chem. Soc. Jpn., 1985, 58, 352). Ethyl 2-(diethoxymethyl)thiazole-4-carboxylate (1.34 g, 5.17 mmol; see step (iv) above) was dissolved in acetone (100 mL) followed by addition of 1N HCl solution (12.8 mL). The reaction mixture was refluxed for 45 min, after which the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (40 mL) and washed sequentially with saturated NaHCO3 solution (2 x 40 mL) and brine (2 x 40 mL). The organic phase was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure to give ethyl 2-formylthiazole-4-carboxylate as a light brown solid (0.937 g, 98% yield). Melting point: 65-67°C (literature value: 67-68°C). IR (KBr, cm^-1): 3116 (Ar-H), 2983, 2910, 2814 (CH), 1730 (C=O), 1513 (C=N), 1060 (C-O). 1H NMR (CDCl3): δ 1.47 (3H, t, CH3, J = 8.0 Hz), 4.0%. 8.0 Hz), 4.50 (2H, q, CH2, J = 8.0 Hz), 8.52 (1H, d, Ar-H, J = 1.2 Hz), 10.08 (1H, d, Ar-CHO, J = 1.2 Hz).HRFABMS: measured value m/z 186.0228 (M + H), calculated value for CH7H7NO3S 185.0147.

References

[1] Bulletin of the Chemical Society of Japan, 1985, vol. 58, # 1, p. 352 - 360
[2] Organic and Biomolecular Chemistry, 2009, vol. 7, # 9, p. 1843 - 1850
[3] Patent: WO2008/38018, 2008, A1. Location in patent: Page/Page column 65
[4] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 21, p. 6827 - 6843
[5] Synthetic Communications, 2012, vol. 42, # 14, p. 2098 - 2109

ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE Suppliers

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73956-17-9, ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATERelated Search:

2,4-Thiazoledicarboxylic acid,4-(diphenylmethyl) 2-ethyl ester 2,4-Thiazoledicarboxylic acid,4-(1,1-dimethylethyl) ester 2,4-Thiazoledicarboxylic acid,4-(1,1-dimethylethyl) 2-ethyl ester ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE

ETHYL-2-FORMYLTHIAZOLE-4-CARBOXYLATE

4-Thiazolecarboxylicacid,2-formyl-,ethylester(9CI)

2-FORMYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

4-Thiazolecarboxylic acid, 2-formyl-, ethyl ester

5-ethyl-2-formyl-4-thiazolecarboxylate

73956-17-9

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