1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL
- Product Name
- 1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL
- CAS No.
- 214147-48-5
- Chemical Name
- 1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL
- Synonyms
- 1-Acetyl-4-aminopiperidine hyd;1-Acetyl-4-aminopiperidine HCl;1-(4-AMino-1-piperidinyl)-ethanone HCl;1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL;1-Acetylpiperidin-4-amine hydrochloride;1-Acetyl-4-aminopiperidine hydrochloride;4-Amino-1-acetylpiperidine hydrochloride;1-Acetylpiperidin-4-amine dihydrochloride;1-(4-Aminopiperidin-1-yl)ethanone hydrochloride;1-(4-Amino-1-piperidinyl)-ethanone hydrochloride
- CBNumber
- CB9846337
- Molecular Formula
- C7H15ClN2O
- Formula Weight
- 178.6598
- MOL File
- 214147-48-5.mol
1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL Property
- Melting point:
- 231-234℃
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- Appearance
- White to off-white Solid
- Sensitive
- Air Sensitive
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 24/25-26-36/37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 728764
- Product name
- 1-Acetyl-4-aminopiperidine hydrochloride
- Purity
- 96%
- Packaging
- 500mg
- Price
- $66
- Updated
- 2023/06/20
- Product number
- A632993
- Product name
- 1-(4-Aminopiperidin-1-yl)ethanoneHydrochloride
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 034755
- Product name
- 1-Acetylpiperidin-4-amine hydrochloride
- Purity
- 97%
- Packaging
- 500mg
- Price
- $51
- Updated
- 2021/12/16
- Product number
- JK983576
- Product name
- 1-Acetylpiperidin-4-aminehydrochloride
- Purity
- 98%
- Packaging
- 250mg
- Price
- $69
- Updated
- 2021/12/16
- Product number
- 034755
- Product name
- 1-Acetylpiperidin-4-amine hydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $79
- Updated
- 2021/12/16
1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL Chemical Properties,Usage,Production
Synthesis
283167-28-2
214147-48-5
The general procedure for the synthesis of 1-acetyl-4-aminopiperidine hydrochloride from tert-butyl (1-methylpiperidin-4-yl)carbamate was as follows: tert-butyl 1-(1-acetylpiperidin-4-yl)carbamate (7.72 g, 44.24 mmol) was dissolved in 1,4-dioxane (100 mL) and cooled to 0 °C, followed by the dropwise addition of 1.4 M HCl of 1,4- dioxane solution (12.2 mL, 48.7 mmol). Upon completion of the dropwise addition, a white precipitate was observed to be generated and the precipitate was separated by filtration. The resulting precipitate was dissolved in methanol (100 mL), 1,4- dioxane solution (12.2 mL, 48.7 mmol) of 4.0 M HCl was added and the reaction mixture was stirred for 16 hours at room temperature. After that, a 1,4-dioxane solution (6.10 mL, 24.4 mmol) of 4.0 M HCl was added and the reaction mixture was heated to 40 °C with continuous stirring for 1.5 hours. After completion of the reaction, the volatile solvent was removed by distillation under reduced pressure and the resulting white solid was dried at high temperature. 1-Acetyl-4-aminopiperidine hydrochloride (8.60 g, purity about 90%, yield >95%) was finally obtained. The structure of the product was confirmed by 1H NMR (400 MHz, d6-DMSO): δ 8.52-8.23 (m, 3H), 4.39-4.26 (m, 1H), 3.89-3.77 (m, 1H), 3.28-3.14 (m, 1H), 3.11-3.00 (m, 1H), 2.65-2.54 (m, 1H), 1.99 (s, 3H), 1.97-1.86 (m, 2H), 1.54-1.41 (m, 1H), 1.41-1.27 (m, 1H).
References
[1] Patent: WO2016/34675, 2016, A1. Location in patent: Page/Page column 68-69
[2] Patent: WO2016/34673, 2016, A1. Location in patent: Page/Page column 91
1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL manufacturers
- Product
- 1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL 214147-48-5
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-01