Uses
ChemicalBook > CAS DataBase List > 4-BROMO-2-METHYLQUINOLINE

4-BROMO-2-METHYLQUINOLINE

Uses
Product Name
4-BROMO-2-METHYLQUINOLINE
CAS No.
50488-44-3
Chemical Name
4-BROMO-2-METHYLQUINOLINE
Synonyms
4-Bromoquinaldine;4-BROMO-2-METHYLQUINOLINE;2-Methyl-4-broMoquinoline;Quinoline, 4-bromo-2-methyl-;4-Bromo-2-methylquinoline 97%min;4-BROMO-2-METHYLQUINOLINE ISO 9001：2015 REACH
CBNumber
CB9846711
Molecular Formula
C10H8BrN
Formula Weight
222.08
MOL File
50488-44-3.mol
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4-BROMO-2-METHYLQUINOLINE Property

Boiling point:
88-90℃ (1 Torr)
Density 
1.488±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
4.21±0.50(Predicted)
Appearance
Yellow to brown Solid
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Safety

HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

TRC
Product number
B697683
Product name
4-Bromo-2-methylquinoline
Packaging
100mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB142712
Product name
4-Bromo-2-methylquinoline
Packaging
250mg
Price
$100
Updated
2021/12/16
AK Scientific
Product number
Z4806
Product name
4-Bromo-2-methylquinoline
Packaging
250mg
Price
$114
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB142712
Product name
4-Bromo-2-methylquinoline
Packaging
500mg
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB142712
Product name
4-Bromo-2-methylquinoline
Packaging
1g
Price
$200
Updated
2021/12/16
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4-BROMO-2-METHYLQUINOLINE Chemical Properties,Usage,Production

Uses

4-Bromo-2-methylquinoline belongs to the quinoline class of organic compounds and can be used as a pharmaceutical intermediate. Literature reports that it can be used to prepare a class of carboxylic acid-substituted (hetero)aromatic ring derivatives with dual inhibitory activity against xanthine oxidase and URAT1, such as 4-(2-cyanoquinoline-4-yl)-2-hydroxybenzoic acid.

Synthesis

607-67-0

50488-44-3

(4a) 4-Hydroxy-2-methylquinoline (17.4 g, 109 mmol) and phosphorus oxyfluoride (47.1 g, 164 mmol) were added in a round bottom flask. The reaction mixture was heated to 130 °C and maintained for several hours. After completion of the reaction, it was cooled to room temperature and the residue was partitioned between saturated Na2CO3 solution and ethyl acetate. The organic layer was separated and the aqueous layer was extracted with ethyl acetate (5 × 300 mL). The organic layers were combined, washed sequentially with H2O (2 × 400 mL) and brine (1 × 400 mL), and dried with anhydrous MgSO4. After filtration, the filtrate was concentrated and the residue was purified by silica gel column chromatography to afford 4-bromo-2-methylquinoline (8.8 g, 36% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 7, p. 1865 - 1870
[2] Patent: US2003/229084, 2003, A1. Location in patent: Page/Page column 33
[3] Patent: WO2017/36404, 2017, A1. Location in patent: Page/Page column 130
[4] Patent: EP96214, 1991, B1
[5] European Journal of Medicinal Chemistry, 2013, vol. 69, p. 527 - 536

4-BROMO-2-METHYLQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BROMO-2-METHYLQUINOLINE Suppliers

China 63 Germany 1 India 2 United Kingdom 1 United States 3 Global 70
Shanghai Sunway Pharmaceutical Technology Co., Ltd
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18270980682
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021 51613951
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mlcheng@sunwaypharm.cn
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China
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Shanghai yirong biology science and technology co., ltd
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18049974220
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+86 (21) 51062076
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3060526242@qq.com
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China
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Chengdu Forest Science and Technology Development Co., Ltd.
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18030648795
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028-61777050
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sales@cdforestchem.com
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China
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Nanjing Norris-Pharm Technology Co., Ltd
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18652989687
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+86-25-52131256
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Shanghai Run-Biotech Co., Ltd.
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021-57171705 13817537615
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China
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Bide Pharmatech Ltd.
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400-164-7117 13681763483
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+86-21-61629029
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product02@bidepharm.com
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China
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Synchem OHG
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+86-21-56795266
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Chengdu Firster Pharmaceutical Co., Ltd.
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028-87078428 028-87074958
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8772-8116
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chengzhenyong@cdfirster.com
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China
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ShangHai AmK Pharmaceutical Technology Co., Ltd.
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微信 17321281695 18019252918
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sale@amkchem.com
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China
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50488-44-3, 4-BROMO-2-METHYLQUINOLINERelated Search:

2-Quinolinol 4-bromo-2-(trifluoromethyl)quinoline Disperse Yellow 64 4-BROMO-8-METHOXY-2-METHYLQUINOLINE 4-BROMO-2-METHYLQUINOLINE 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE 4-BROMO-6-METHOXY-2-METHYLQUINOLINE 3,4-Dibromo-2-methylquinoline 4-BROMOQINOLINE-2-CARBOXALDEHYDE 4-BROMO-2,8-DIMETHYLQUINOLINE 4,6-DIBROMO-2-PHENYLQUINOLINE 4-BROMO-2-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ACID 4-BROMOQUINOLINE-2-CARBOXYLIC ACID 4,6-DIBROMO-2-METHYLQUINOLINE

  • 2-Methyl-4-broMoquinoline
  • 4-BROMO-2-METHYLQUINOLINE
  • 4-Bromoquinaldine
  • Quinoline, 4-bromo-2-methyl-
  • 4-BROMO-2-METHYLQUINOLINE ISO 9001：2015 REACH
  • 4-Bromo-2-methylquinoline 97%min
  • 50488-44-3