2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE

Product Name: 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE
CAS No.: 35853-45-3
Chemical Name: 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE
Synonyms: 2,8-BIS(TRIFL;)-4-BROMOQUINOL;1-METHYL-3-(AMINOMETHYL)PIPERIDINE;2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLIN;4-BROMO-2,8-BIS(TRIFLUOROMETHYL)QUINOLINE;2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE;Quinoline, 4-bromo-2,8-bis(trifluoromethyl)-;4-Bromo-2,8-bis(trifluoromethyl)quinoline, >=98%;2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE ISO 9001：2015 REACH
CBNumber: CB7173196
Molecular Formula: C11H4BrF6N
Formula Weight: 344.05
MOL File: 35853-45-3.mol

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2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE Property

Melting point:: 62-64 °C(lit.)
Boiling point:: 281.6±35.0 °C(Predicted)
Density: 1.720±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Crystalline Powder
pka: -3.67±0.50(Predicted)
color: Off-white to yellow

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B810378
Product name: 4-Bromo-2,8-bis(trifluoromethyl)quinoline
Packaging: 500mg
Price: $100
Updated: 2021/12/16

Apolloscientific

Product number: PC407017
Product name: 2,8-Bis(trifluoromethyl)-4-bromoquinoline
Packaging: 1g
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: W5740
Product name: 4-Bromo-2,8-bis(trifluoromethyl)quinoline
Packaging: 250mg
Price: $40
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB08107
Product name: 4-Bromo-2,8-bis(trifluoromethyl)quinoline
Packaging: 1g
Price: $280
Updated: 2021/12/16

Matrix Scientific

Product number: 090407
Product name: 4-Bromo-2,8-bis(trifluoromethyl)quinoline
Purity: 95+%
Packaging: 1g
Price: $284
Updated: 2021/12/16

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2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE Chemical Properties,Usage,Production

Synthesis

35853-41-9

35853-45-3

Under argon protection, phosphorus bromide oxide (4 g, 14.2 mmol) was heated to 90 °C until the solid was completely dissolved. To this hot solution was added 2,8-bis(trifluoromethyl)-4-hydroxyquinoline (4.08 g, 14.2 mmol) and the temperature of the oil bath was raised to 150 °C. After 6 hours of reaction, the mixture was cooled to room temperature. The reaction was quenched by the addition of ice water and the resulting precipitate was filtered and washed with cold water to afford the target product 4-bromo-2,8-bis(trifluoromethyl)quinoline (4.70 g, 96% yield) as a white solid. Thin layer chromatography (TLC) Rf value was 0.79 (unfolding agent: cyclohexane/ether=5:1). Melting point: 60°C. 1H NMR (300 MHz, CDCl3) δ 7.82 (t, J=7.9 Hz, 1H), 8.11 (s, 1H), 8.22 (d, J=7.3 Hz, 1H), 8.46 (d, J=8.6 Hz, 1H). 13C NMR (125 MHz, CDCl3) δ 120.9 (q, J= 276.0 Hz), 122.0 (q, J=2.0 Hz), 123.6 (q, J=273.8 Hz), 128.9, 129.4, 129.8 (q, J=30.8 Hz), 130.5 (q, J=5.3 Hz), 131.5, 138.5, 144.5, 148.6 (q, J=36.1 Hz). Infrared spectra (IR) νmax: 1577, 1422, 1302, 1136, 1098, 1010, 876, 824 cm-1. gas chromatography-mass spectrometry (GC-MS) m/z: 343. high-resolution mass spectrometry (HRMS) calculated value of C11H4BrF6Na(M+Na)+: 365.9329, measured value: 365.9346.

References

[1] Angewandte Chemie - International Edition, 2015, vol. 54, # 47, p. 14070 - 14074
[2] Angew. Chem., 2015, vol. 127, # 47, p. 14276 - 14280,5
[3] Journal of Organic Chemistry, 2016, vol. 81, # 20, p. 9567 - 9575
[4] Tetrahedron Asymmetry, 2011, vol. 22, # 2, p. 138 - 148
[5] Patent: WO2012/107532, 2012, A1. Location in patent: Page/Page column 20-21

2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE Suppliers

Belgium 1 Canada 1 CHINA 92 Germany 5 India 4 Switzerland 1 The Netherlands 1 United Kingdom 9 United States 23 Global 137

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Thermo Fisher Scientific

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View Lastest Price from 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE manufacturers

Career Henan Chemical Co

Product: 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE 35853-45-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-30

35853-45-3, 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINERelated Search:

4-bromo-2-(trifluoromethyl)quinoline 4-Bromoquinoline 4-Bromo-2-methylpyridine 8-Methylquinoline 4-BROMO-8-TRIFLUOROMETHYLQUINOLINE 8-Trifluoromethylquinoline 4-BROMO-8-METHYLQUINOLINE 4-Bromopyridine 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE 2,8-Dimethylquinoline 2-(Trifluoromethyl)pyridine 8-METHYL-2-TRIFLUOROMETHYLQUINOLINE 4-BROMO-2-TRIFLUOROMETHYLPYRIDINE 4-BROMO-2-METHYLQUINOLINE 2-TRIFLUOROMETHYLQUINOLINE 4-BROMO-2,8-DIMETHYLQUINOLINE 2-FLUOROMETHYL-PYRIDINE

2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE

4-BROMO-2,8-BIS(TRIFLUOROMETHYL)QUINOLINE

2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLIN

4-Bromo-2,8-bis(trifluoromethyl)quinoline, >=98%

1-METHYL-3-(AMINOMETHYL)PIPERIDINE

2,8-BIS(TRIFL

Quinoline, 4-bromo-2,8-bis(trifluoromethyl)-

)-4-BROMOQUINOL

2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE ISO 9001：2015 REACH

35853-45-3

C11H4BrF6N

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