ChemicalBook > CAS DataBase List > BUTYROLACETONE 3
BUTYROLACETONE 3
- Product Name
- BUTYROLACETONE 3
- CAS No.
- 778649-18-6
- Chemical Name
- BUTYROLACETONE 3
- Synonyms
- Butyrolactone 3;BUTYROLACETONE 3;GCN5 INHIBITOR 1;3-Furancarboxylic acid, tetrahydro-4-methylene-5-oxo-2-propyl-, (2R,3S)-rel-
- CBNumber
- CB9848548
- Molecular Formula
- C9H12O4
- Formula Weight
- 184.19
- MOL File
- 778649-18-6.mol
More
Less
BUTYROLACETONE 3 Property
- storage temp.
- -20°C
- solubility
- ≤14mg/ml in ethanol;14mg/ml in DMSO;13mg/ml in dimethyl formamide
- form
- powder
- color
- white to off-white
- Stability:
- Light Sensitive
More
Less
Safety
- WGK Germany
- nwg
More
Less
More
Less
N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 12095
- Product name
- Butyrolactone 3
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $54
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 12095
- Product name
- Butyrolactone 3
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $155
- Updated
- 2024/03/01
TRC
- Product number
- B761010
- Product name
- Butyrolactone3
- Packaging
- 50mg
- Price
- $1315
- Updated
- 2021/12/16
Usbiological
- Product number
- 207098
- Product name
- Butyrolactone 3
- Packaging
- 2mg
- Price
- $325
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0103268
- Product name
- Butyrolactone3
- Purity
- ≥98.0%
- Packaging
- 10mg
- Price
- $400
- Updated
- 2021/12/16
More
Less
BUTYROLACETONE 3 Chemical Properties,Usage,Production
Uses
Butyrolactone 3 is a selective inhibitor of histone acetyltransferase Gcn5 with affinity for the enzyme comparable to its natural substrate. Butyrolactone 3 is very useful tool in understanding and further studying the histone code.
Definition
ChEBI: (2S,3R)-4-methylene-5-oxo-2-propyl-3-oxolanecarboxylic acid is a gamma-lactone.
in vitro
the analogs of butyrolactone 3 only showed a weak inhibition of cbp, while butyrolactone 3 led to an inhibition of gcn5. it was important to see that in the presence of acetyl-coa the kd value for binding of histone h3 to gcn5 or pcaf was around 100 mm. moreover, the affinity of butyrolactone 3 to the gcn5 enzyme was found to be comparable to that of the natural substrate h3 and could provide an good starting point for the study of sar. in addition, a nonirreversible inhibition of gcn5 could be determine, and thus a michael addition of nucleophilic groups of the enzymebs active side was unlikely. therefore, the derivatization of gbutyrolactone 3 at position 2 might be a promising starting point for future sar studies [1].
IC 50
100 μm
References
1. m. biel, a. kretsovali, e. karatzali, et al. design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase gcn5. angewandte chemie international edition 43, 3974-3976 (2004).
BUTYROLACETONE 3 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
BUTYROLACETONE 3 Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-33632979
- Fax
- 021-34692979
- info@tsbiochem.com
- Country
- China
- ProdList
- 8065
- Advantage
- 58
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51456
- Advantage
- 80
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 15971444841
- Fax
- 18327183813
- amber@biochempartner.com
- Country
- China
- ProdList
- 3061
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57412
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11217
- Advantage
- 58
- Tel
- 020-82000279 18988968278
- Fax
- QQ：3283937693
- sales@ubiochem.com
- Country
- China
- ProdList
- 4297
- Advantage
- 58
- Tel
- 15869524721
- 3525679403@qq.com
- Country
- China
- ProdList
- 3991
- Advantage
- 58
- Tel
- 15342225168
- yutianchun2007@126.com
- Country
- China
- ProdList
- 10002
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29774
- Advantage
- 58
- Tel
- 13774214275
- zhouzz@univ-bio.com
- Country
- China
- ProdList
- 24990
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24647
- Advantage
- 58
- Tel
- 021-50706066 15221275939
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 29794
- Advantage
- 58
- Tel
- 18014399201
- sales@chemlab-tachizaki.com
- Country
- China
- ProdList
- 2565
- Advantage
- 58
- Tel
- 024-024-88590548 18341751992
- 757984502@qq.com
- Country
- China
- ProdList
- 891
- Advantage
- 58
- Tel
- 025-66113011 18112977050
- cb5@aikonchem.com
- Country
- China
- ProdList
- 10528
- Advantage
- 58
- Tel
- 021-59167510 18117107507
- vip@med-life.cn
- Country
- China
- ProdList
- 4997
- Advantage
- 58
- Tel
- 18024082417
- market@ubiochem.com
- Country
- China
- ProdList
- 9272
- Advantage
- 58
- Tel
- +86-18341751992 +86-15382112998
- 757984502@qq.com
- Country
- China
- ProdList
- 892
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- 470003480@QQ.COM
- Country
- CHINA
- ProdList
- 6955
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1861586486@qq.com
- Country
- CHINA
- ProdList
- 6648
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6973
- Advantage
- 58
- Tel
- --
- Fax
- --
- 13851015143@163.com
- Country
- CHINA
- ProdList
- 6146
- Advantage
- 58
- Tel
- --
- Fax
- --
- 3007606172@qq.com
- Country
- CHINA
- ProdList
- 6002
- Advantage
- 58
- Tel
- --
- Fax
- --
- lyn@biopike.com.cn
- Country
- CHINA
- ProdList
- 6629
- Advantage
- 58
- Tel
- --
- Fax
- --
- 2453006496@qq.com
- Country
- CHINA
- ProdList
- 6184
- Advantage
- 58
- Tel
- --
- Fax
- --
- 344843571@qq.com
- Country
- CHINA
- ProdList
- 6318
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@f-biology.com
- Country
- CHINA
- ProdList
- 6025
- Advantage
- 58
- Tel
- --
- Fax
- --
- service@neobioscience.com
- Country
- CHINA
- ProdList
- 6151
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1985563437@qq.com
- Country
- CHINA
- ProdList
- 6158
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1914109725@qq.com
- Country
- CHINA
- ProdList
- 6518
- Advantage
- 58
- Tel
- --
- Fax
- --
- huaxiabio@163.com
- Country
- CHINA
- ProdList
- 6122
- Advantage
- 58
- Tel
- --
- Fax
- --
- john.st@163.com
- Country
- CHINA
- ProdList
- 1471
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6057
- Advantage
- 58
- Tel
- --
- Fax
- --
- bj_info@dakewe.net
- Country
- CHINA
- ProdList
- 6348
- Advantage
- 58
- Tel
- --
- Fax
- --
- 912529879@qq.com
- Country
- CHINA
- ProdList
- 6835
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenxue_gz@163.com
- Country
- CHINA
- ProdList
- 6600
- Advantage
- 58
- Tel
- --
- Fax
- --
- shxiyuanbio@163.com
- Country
- CHINA
- ProdList
- 6906
- Advantage
- 58
- Tel
- --
- Fax
- --
- jijinhuaxue@sina.com
- Country
- CHINA
- ProdList
- 6606
- Advantage
- 58
- Tel
- --
- Fax
- --
- yangmei@bioneeds.net
- Country
- CHINA
- ProdList
- 6999
- Advantage
- 58
- Tel
- --
- Fax
- --
- market@xlswkj.com
- Country
- CHINA
- ProdList
- 6793
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1562893815@qq.com
- Country
- CHINA
- ProdList
- 6936
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@wheybio.com
- Country
- CHINA
- ProdList
- 4398
- Advantage
- 58