BUTYROLACETONE 3
- Product Name
- BUTYROLACETONE 3
- CAS No.
- 778649-18-6
- Chemical Name
- BUTYROLACETONE 3
- Synonyms
- Butyrolactone 3;BUTYROLACETONE 3;GCN5 INHIBITOR 1;3-Furancarboxylic acid, tetrahydro-4-methylene-5-oxo-2-propyl-, (2R,3S)-rel-
- CBNumber
- CB9848548
- Molecular Formula
- C9H12O4
- Formula Weight
- 184.19
- MOL File
- 778649-18-6.mol
BUTYROLACETONE 3 Property
- storage temp.
- -20°C
- solubility
- ≤14mg/ml in ethanol;14mg/ml in DMSO;13mg/ml in dimethyl formamide
- form
- powder
- color
- white to off-white
- Stability:
- Light Sensitive
Safety
- WGK Germany
- nwg
N-Bromosuccinimide Price
- Product number
- 12095
- Product name
- Butyrolactone 3
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $54
- Updated
- 2024/03/01
- Product number
- 12095
- Product name
- Butyrolactone 3
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $155
- Updated
- 2024/03/01
- Product number
- B761010
- Product name
- Butyrolactone3
- Packaging
- 50mg
- Price
- $1315
- Updated
- 2021/12/16
- Product number
- 207098
- Product name
- Butyrolactone 3
- Packaging
- 2mg
- Price
- $325
- Updated
- 2021/12/16
- Product number
- CS-0103268
- Product name
- Butyrolactone3
- Purity
- ≥98.0%
- Packaging
- 10mg
- Price
- $400
- Updated
- 2021/12/16
BUTYROLACETONE 3 Chemical Properties,Usage,Production
Uses
Butyrolactone 3 is a selective inhibitor of histone acetyltransferase Gcn5 with affinity for the enzyme comparable to its natural substrate. Butyrolactone 3 is very useful tool in understanding and further studying the histone code.
Definition
ChEBI: (2S,3R)-4-methylene-5-oxo-2-propyl-3-oxolanecarboxylic acid is a gamma-lactone.
in vitro
the analogs of butyrolactone 3 only showed a weak inhibition of cbp, while butyrolactone 3 led to an inhibition of gcn5. it was important to see that in the presence of acetyl-coa the kd value for binding of histone h3 to gcn5 or pcaf was around 100 mm. moreover, the affinity of butyrolactone 3 to the gcn5 enzyme was found to be comparable to that of the natural substrate h3 and could provide an good starting point for the study of sar. in addition, a nonirreversible inhibition of gcn5 could be determine, and thus a michael addition of nucleophilic groups of the enzymebs active side was unlikely. therefore, the derivatization of gbutyrolactone 3 at position 2 might be a promising starting point for future sar studies [1].
IC 50
100 μm
References
1. m. biel, a. kretsovali, e. karatzali, et al. design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase gcn5. angewandte chemie international edition 43, 3974-3976 (2004).
BUTYROLACETONE 3 Preparation Products And Raw materials
Raw materials
Preparation Products
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