ChemicalBook > CAS DataBase List > 2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE

2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE

Product Name
2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE
CAS No.
70006-24-5
Chemical Name
2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE
Synonyms
ABT 724;ABT-724, 10 mM in DMSO;ABT 724 TRIHYDROCHLORIDE;2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole;1H-Benzimidazole, 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-;2-((4-(Pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole;2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE;ABT 724,Inhibitor,Dopamine Receptor,penile,erection,D4-receptor,Dopamine,ABT-724,inhibit,ABT724,potentiation,side-effect
CBNumber
CB9850686
Molecular Formula
C17H19N5
Formula Weight
293.37
MOL File
70006-24-5.mol
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2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE Property

storage temp. 
Inert atmosphere,2-8°C
form 
solid
color 
White
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Tocris
Product number
2214
Product name
ABT-724 trihydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$144
Updated
2021/12/16
Tocris
Product number
2214
Product name
ABT-724 trihydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$603
Updated
2021/12/16
TRC
Product number
A112605
Product name
ABT724
Packaging
50mg
Price
$100
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BRS0000085
Product name
ABT-724
Purity
95.00%
Packaging
10MG
Price
$697.34
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BRS0000085
Product name
ABT-724
Purity
95.00%
Packaging
50MG
Price
$1170.31
Updated
2021/12/16
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2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

ABT 724 trihydrochloride is a potent dopamine D4 receptor agonist. ABT 724 is used in pharmacology systems for treating ocular disorders.

Definition

ChEBI: 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole is a member of pyridines and a member of piperazines.

Biological Activity

Potent dopamine D 4 receptor partial agonist (EC 50 = 12.4 nM; 61% efficacy vs. dopamine). Has no agonist activity at D 2 receptors (EC 50 > 10 μ M). Selective in rats in vivo : produces penile erection following i.c.v. administration; increases intracavernosal pressure and potentiates the proerectile effects of sildenafil following s.c. administration. Displays minimal side effects.

2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE Suppliers

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70006-24-5, 2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDERelated Search:

2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE

  • ABT 724 TRIHYDROCHLORIDE
  • 2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE
  • 2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole
  • ABT 724
  • 1H-Benzimidazole, 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-
  • ABT 724,Inhibitor,Dopamine Receptor,penile,erection,D4-receptor,Dopamine,ABT-724,inhibit,ABT724,potentiation,side-effect
  • 2-((4-(Pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole
  • ABT-724, 10 mM in DMSO
  • 70006-24-5
  • C17H22Cl3N5
  • C17H19N53HCl