ChemicalBook > CAS DataBase List > (S)-Methyl 2-aminobutanoate

(S)-Methyl 2-aminobutanoate

Product Name
(S)-Methyl 2-aminobutanoate
CAS No.
15399-22-1
Chemical Name
(S)-Methyl 2-aminobutanoate
Synonyms
H-Abu-OMe;H-ABU-OME HCL;Levetiracetam-10;Methyl (2S)​Levetiracetam Impurity J;Levetiracetam Impurity 14;Levetiracetam impuritiesJ;Methyl (2S)-Aminobutanoate;Levetiracetam impurities513;(S)-Methyl 2-aminobutanoate
CBNumber
CB9850868
Molecular Formula
C5H11NO2
Formula Weight
117.15
MOL File
15399-22-1.mol
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(S)-Methyl 2-aminobutanoate Property

Boiling point:
127.8±13.0 °C(Predicted)
Density 
0.987±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
7.89±0.29(Predicted)
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Safety

HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M285735
Product name
Methyl(2S)​-​2-​Aminobutanoate
Packaging
5g
Price
$250
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA107933
Product name
H-Abu-OMe·HCl
Packaging
1g
Price
$94
Updated
2021/12/16
Activate Scientific
Product number
AS47651
Product name
(S)-Methyl 2-aminobutanoate
Purity
97% ee
Packaging
1g
Price
$158
Updated
2021/12/16
Activate Scientific
Product number
AS47651
Product name
(S)-Methyl 2-aminobutanoate
Purity
97% ee
Packaging
5G
Price
$430
Updated
2021/12/16
AK Scientific
Product number
B311
Product name
Methyl(2S)-2-Aminobutanoate
Packaging
5g
Price
$474
Updated
2021/12/16
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(S)-Methyl 2-aminobutanoate Chemical Properties,Usage,Production

Uses

Methyl (2S)?-?2-?Aminobutanoate is a general chemical reagent used in the synthesis of methylsulphonamide based small molecule legumain inhibitors.

Synthesis

67-56-1

1492-24-6

2483-62-7

Step 1: Preparation of methyl (2S)-2-aminobutyrate; (2S)-2-aminobutyric acid (21.56 g, 0.21 mol) was dissolved in 120 mL of methanol. The reaction mixture was cooled to 0°C in an ice-water bath and thionyl chloride (30.5 mL, 0.42 mol) was added slowly and dropwise with continuous stirring. After the dropwise addition, the reaction mixture was heated to reflux for 2 hours and subsequently cooled to room temperature. The solvent was removed by concentration under reduced pressure to afford methyl (2S)-2-aminobutyrate (31.87 g, 99.3% yield) as a white solid.

References

[1] Patent: EP2481739, 2012, A1. Location in patent: Page/Page column 78
[2] Patent: US2012/184543, 2012, A1. Location in patent: Page/Page column 79
[3] Patent: WO2009/23655, 2009, A1. Location in patent: Page/Page column 53
[4] Journal of the American Chemical Society, 1991, vol. 113, # 11, p. 4297 - 4303
[5] Justus Liebigs Annalen der Chemie, 1961, vol. 649, p. 183 - 202

(S)-Methyl 2-aminobutanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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15399-22-1, (S)-Methyl 2-aminobutanoateRelated Search:

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