1-(2-Fluoro-5-nitrophenyl)ethan-1-one
- Product Name
- 1-(2-Fluoro-5-nitrophenyl)ethan-1-one
- CAS No.
- 79110-05-7
- Chemical Name
- 1-(2-Fluoro-5-nitrophenyl)ethan-1-one
- Synonyms
- 1-(2-Fluoro-5-nitrophenyl)ethanone;2'-FLUORO-5'-NITROACETOPHENONE;2'-Fluoro-5'-nitroacetophenone 96%;Ethanone,1-(2-fluoro-5-nitrophenyl)-;1-(2-Fluoro-5-nitrophenyl)ethan-1-one;1-(2-Fluoro-5-nitrophenyl)ethan-1-one ISO 9001：2015 REACH;1-(2-Fluoro-5-nitrophenyl)ethan-1-one, 3-Acetyl-4-fluoronitrobenzene
- CBNumber
- CB9854396
- Molecular Formula
- C8H6FNO3
- Formula Weight
- 183.14
- MOL File
- 79110-05-7.mol
1-(2-Fluoro-5-nitrophenyl)ethan-1-one Property
- Melting point:
- 53-54 °C
- Boiling point:
- 241.0±20.0 °C(Predicted)
- Density
- 1.336±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- color
- White to Yellow to Green
- InChI
- InChI=1S/C8H6FNO3/c1-5(11)7-4-6(10(12)13)2-3-8(7)9/h2-4H,1H3
- InChIKey
- BCXOSCQTHVTUET-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC([N+]([O-])=O)=CC=C1F)C
Safety
- Hazard Codes
- Xi
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F1199
- Product name
- 2'-Fluoro-5'-nitroacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $81
- Updated
- 2025/07/31
- Product number
- F1199
- Product name
- 2'-Fluoro-5'-nitroacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $322
- Updated
- 2025/07/31
- Product number
- F597575
- Product name
- 2''-Fluoro-5''-nitroacetophenone
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CS-D1637
- Product name
- 1-(2-Fluoro-5-nitrophenyl)ethanone
- Purity
- 99.64%
- Packaging
- 25g
- Price
- $67
- Updated
- 2021/12/16
- Product number
- 4654-3-X8
- Product name
- 2'-Fluoro-5'-nitroacetophenone
- Packaging
- 5G
- Price
- $79
- Updated
- 2021/12/16
1-(2-Fluoro-5-nitrophenyl)ethan-1-one Chemical Properties,Usage,Production
Uses
2''-Fluoro-5''-nitroacetophenone
Synthesis
445-27-2
79110-05-7
A solution of 1-(2-fluorophenyl)ethanone (90.0 g, 652 mmol) with fuming nitric acid (53.1 mL) in concentrated sulfuric acid (129 mL) was slowly added dropwise to concentrated sulfuric acid (360 mL, 93-98%) pre-cooled to -42 °C under mechanical stirring. The reaction mixture was kept stirred at -42°C for 30 minutes. Upon completion of the reaction, the mixture was slowly poured into ice (1.3 kg) to quench the reaction. Subsequently, water (1 L) was added to precipitate the product from the solution. After all the ice melted, the precipitate was collected by filtration. The resulting solid was dissolved in EtOAc and the organic layer was washed sequentially with 5% aqueous Na2CO3 (2 x 300 mL), water (1 x 300 mL) and brine (1 x 300 mL), dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated to give a yellow solid 1-(2-fluoro-5-nitrophenyl)ethanone (115 g, 97% yield).
References
[1] Patent: WO2012/139425, 2012, A1. Location in patent: Page/Page column 117
[2] Patent: WO2011/44184, 2011, A1. Location in patent: Page/Page column 99-100
[3] Patent: US2004/122237, 2004, A1. Location in patent: Page 388
[4] Journal of Heterocyclic Chemistry, 1991, vol. 28, # 3, p. 673 - 683
[5] Patent: US2002/151715, 2002, A1
1-(2-Fluoro-5-nitrophenyl)ethan-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(2-Fluoro-5-nitrophenyl)ethan-1-one manufacturers
- Product
- 1-(2-Fluoro-5-nitrophenyl)ethan-1-one 79110-05-7
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-26
- Product
- 1-(2-Fluoro-5-nitrophenyl)ethan-1-one 79110-05-7
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100 tons
- Release date
- 2020-01-10
- Product
- 1-(2-Fluoro-5-nitrophenyl)ethan-1-one 79110-05-7
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24