2,5-Dimethylaniline Property

Melting point:

11.5 °C(lit.)

Boiling point:

218 °C(lit.)

Density 

0.973 g/mL at 25 °C(lit.)

vapor pressure 

20Pa

refractive index 

n20/D 1.559(lit.)

Flash point:

201 °F

storage temp. 

Store below +30°C.

solubility 

Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Sparingly)

form 

Liquid

pka

pK1:4.53(+1) (25°C)

color 

Clear yellow to red-brown

Water Solubility 

<0.1 g/100 mL at 18 ºC

Merck 

14,10084

BRN 

2205178

LogP

1.83

CAS DataBase Reference

95-78-3(CAS DataBase Reference)

IARC

3 (Vol. 16, Sup 7) 1987

NIST Chemistry Reference

Benzenamine, 2,5-dimethyl-(95-78-3)

EPA Substance Registry System

2,5-Dimethylaniline (95-78-3)

Safety

Hazard Codes 

T,N,Xn

Risk Statements 

23/24/25-33-51/53-48/20

Safety Statements 

28-36/37-45-61-28A

RIDADR 

UN 1711 6.1/PG 2

WGK Germany 

3

RTECS 

ZE9100000

F 

8-10-23

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29214910

Hazardous Substances Data

95-78-3(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

2,5-Dimethylaniline Chemical Properties,Usage,Production

Chemical Properties

clear yellow to red-brown liquid

Uses

The uses are the same as those of xylidines.

Uses

2,5-Dimethylaniline is widely used as raw materials to produce imaging chemicals like organic dyes and pigments. It is also used in the production of antioxidants, pharmaceutical, agricultural, rubber chemicals and other target organic molecules. 2,5-Dimethylaniline was also used in the synthesis of nanocomposite of multi-walled carbon nanotubes embedded in poly(2,5-dimethylaniline). 2,5-Dimethylaniline was used to study the effect of metabolites formed from 2,5-xylidine by fungi on laccase activity. The Fourier transform infrared (FTIR) and Raman spectra of 2,5-dimethylaniline was studied5. It induced transcription of lccIV.

Uses

2,5-Dimethylaniline was used in the synthesis of nanocomposite of multi-walled carbon nanotubes embedded in poly(2,5-dimethylaniline). 2,5-Dimethylaniline was used to study the effect of metabolites formed from 2,5-xylidine by fungi on laccase activity.

Definition

ChEBI: A primary arylamine that is aniline in which the hydrogens at the 2- and 5-positions are replaced by methyl groups. It is used in the manufacture of dyes and other chemicals.

General Description

Dark brown liquid.

Air & Water Reactions

2,5-Dimethylaniline may be sensitive to prolonged exposure to air. Insoluble in water.

Reactivity Profile

2,5-Dimethylaniline ignites on contact with fuming nitric acid . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Fire Hazard

2,5-Dimethylaniline is combustible.

Safety Profile

Suspected carcinogen. A poison. Moderately toxic by ingestion. Quesuonable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also other xylidme entries.

Purification Methods

Convert p-xylidine to a derivative (see below) which, after recrystallisation, is decomposed with alkali to give the free base. Dry over KOH and fractionally distil. The acetyl derivative has m 142o (from H2O or toluene), and the benzoyl derivative has m 140o (from EtOH). [Beilstein 12 H 1135, 12 IV 2567.]