Astragaloside III

ChemicalBook > CAS DataBase List > Astragaloside III

Product Name: Astragaloside III
CAS No.: 84687-42-3
Chemical Name: Astragaloside III
Synonyms: Astragaloside-Ⅲ;Astragaloside III;Astragaloside III-RM;ASTRAGALOSIDE III(SH);Astragaloside III,98%;Balofloxacin Impurity 4;2'-Dihydroxy-3',4'-dimethoxyisoflavan-7-O-β-D-glucopyranoside;β-D-Xylopyranoside,(3β,6α,16β,20R,24S)-20,24-epoxy-6,16,25-trihydroxy-9,19-cyclolanostan-3-yl2-O-β-D-glucopyranosyl-;b-D-Xylopyranoside, (3b,6a,16b,20R,24S)-20,24-epoxy-6,16,25-trihydroxy-9,19-cyclolanostan-3-yl 2-O-b-D-glucopyranosyl-
CBNumber: CB9854891
Molecular Formula: C41H68O14
Formula Weight: 784.97
MOL File: 84687-42-3.mol

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Astragaloside III Property

Melting point:: 245～247℃
Boiling point:: 906.8±65.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Methanol (Slightly), Pyridine (Slightly)
form: Solid
pka: 12.89±0.70(Predicted)
color: White to Off-White
InChI: InChI=1/C41H68O14/c1-35(2)24(53-34-30(26(46)21(45)17-51-34)54-33-29(49)28(48)27(47)22(16-42)52-33)9-11-41-18-40(41)13-12-37(5)32(39(7)10-8-25(55-39)36(3,4)50)20(44)15-38(37,6)23(40)14-19(43)31(35)41/h19-34,42-50H,8-18H2,1-7H3/t19-,20-,21+,22+,23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33-,34-,37+,38-,39-,40-,41+/s3
InChIKey: FVFSMBDVZVUETN-HCAUMGIPNA-N
SMILES: [C@@]123CC[C@]4(C)[C@@]([C@@H](O)C[C@@]4(C)[C@]1([H])C[C@H](O)[C@@]1([H])C([C@@H](O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)CC[C@]21C3)(C)C)([H])[C@]1(C)CC[C@@H](C(C)(C)O)O1 |&1:0,3,5,6,9,11,14,16,19,21,24,26,28,30,32,35,37,39,43,48,52,r|

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Safety

HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL80357
Product name: Astragaloside III
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $875
Updated: 2024/03/01

Sigma-Aldrich

Product number: SMB00317
Product name: Astragaloside III
Purity: ≥96% (HPLC)
Packaging: 5MG
Price: $304
Updated: 2023/06/20

Cayman Chemical

Product number: 22432
Product name: Astragaloside III
Purity: ≥95%
Packaging: 500μg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 22432
Product name: Astragaloside III
Purity: ≥95%
Packaging: 1mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 22432
Product name: Astragaloside III
Purity: ≥95%
Packaging: 5mg
Price: $214
Updated: 2024/03/01

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Astragaloside III Chemical Properties,Usage,Production

Description

Astragaloside III is a saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine. It is bioavailable after oral administration, distributed mainly to the thymus and spleen, and has a half-life of approximately 2 hours.

Uses

Astragaloside III has cardioprotective effects as well as causing improvement in cognitive function. Used in the prevention of cardio-cerebral vascular diseases. Antioxidant.

Definition

ChEBI: A triterpenoid saponin that is cycloastragenol with a 2-O-beta-D-glucopyranosyl-beta-D-xylopyranosyl moiety attached at position 3 via a glycosidic linkage.

benefits

Astragaloside III is a natural compound from Astragalus that has been shown to have immunomodulatory effects in various systems. Astragaloside III significantly elevated the expression of natural killer group 2D (NKG2D), Fas, and interferon-γ (IFN-γ) production in NK cells, increasing tumor-killing ability. It could effectively impede tumour growth by increasing the infiltration of NK cells into the tumour and upregulating the antitumor response of NK cells. In addition, Astragaloside III increased IFN-γ secretion of NK cells by enhancing the expression of transcription factor T-bet. In conclusion, the effective antitumor function of Astragaloside III was achieved through up-regulation of the immune response of NK cells and elevation of NKG2D, Fas, and IFN-γ production[2].

Biological Activity

Astragaloside III exhibited the highest interaction energy value of -8.718 kcal/mol and -8.447 kcal/mol against envelope and NS2b/NS3 targets, respectively. Astragaloside IV exhibited -7.244 kcal/mol against the SAM site and -9.179 kcal/mol against the RNA cap site of NS5 targets. In silico ADMET analysis revealed that astragaloside II, III, and IV were non-mutagenic and non-carcinogenic, and these compounds were also non-toxic to Vero cells up to 1000 μg/mL. Against dengue virus serotype 3, astragaloside II exhibited substantial antiviral activity at the concentration of 1.56 μg/mL, followed by astragaloside III at 6.25 μg/mL and astragaloside IV at 12.5 μg/mL. Also, against dengue serotype 1, astragaloside II showed the maximum antiviral activity at 1.56 μg/mL, followed by astragaloside III and IV at 3.125 μg/mL[1].

Side effects

However, minor side effects have been reported in studies, such as a rash, itching, runny nose, nausea and diarrhea. When given by IV, astragalus may have more severe side effects, such as irregular heartbeat. It should only be administered by IV or injection under medical supervision.

References

[1] Purushothaman Indu M.Sc . “Antiviral activity of astragaloside II, astragaloside III and astragaloside IV compounds against dengue virus: Computational docking and in vitro studies.” Microbial pathogenesis 152 (2021): Article 104563.
[2] Xingmeng Chen. “Astragaloside III Enhances Anti-Tumor Response of NK Cells by Elevating NKG2D and IFN-γ.” Frontiers in Pharmacology (2019).

Astragaloside III Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Astragaloside III manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Astragaloside III 84687-42-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-22

Shanghai Standard Technology Co., Ltd.

Product: Astragaloside III 84687-42-3
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-02-27

Career Henan Chemical Co

Product: Astragaloside III 84687-42-3
Price: US $8.00/KG
Min. Order: 1g
Purity: ＞98% HPLC
Supply Ability: kg--ton
Release date: 2020-02-20

84687-42-3, Astragaloside IIIRelated Search:

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Astragaloside-Ⅲ

Astragaloside III

β-D-Xylopyranoside,(3β,6α,16β,20R,24S)-20,24-epoxy-6,16,25-trihydroxy-9,19-cyclolanostan-3-yl2-O-β-D-glucopyranosyl-

ASTRAGALOSIDE III(SH)

b-D-Xylopyranoside, (3b,6a,16b,20R,24S)-20,24-epoxy-6,16,25-trihydroxy-9,19-cyclolanostan-3-yl 2-O-b-D-glucopyranosyl-

Astragaloside III,98%

Balofloxacin Impurity 4

2'-Dihydroxy-3',4'-dimethoxyisoflavan-7-O-β-D-glucopyranoside

Astragaloside III-RM

84687-42-3

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

The group of Astralosides