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Escin

Product Name
Escin
CAS No.
6805-41-0
Chemical Name
Escin
Synonyms
AESCIN;BETA-AESCIN;escina;Escine;Escin USP/EP/BP;044;ESCIN;a-4700;UK-116;reparilu
CBNumber
CB1728224
Molecular Formula
C55H86O24
Formula Weight
1131.26
MOL File
6805-41-0.mol
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Escin Property

Melting point:
224.5°C
Boiling point:
764.81°C (rough estimate)
Density 
1.1200 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
4°C, protect from light
solubility 
Soluble in methanol.
form 
powder
color 
white
Merck 
13,3730
Stability:
Hygroscopic
CAS DataBase Reference
6805-41-0
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Safety

Hazard Codes 
Xn
Risk Statements 
22-20/22
Safety Statements 
22-24/25
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2
RTECS 
KF6296000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E1378
Product name
Escin
Purity
≥95%, powder
Packaging
1g
Price
$103
Updated
2024/03/01
Sigma-Aldrich
Product number
E1378
Product name
Escin
Purity
≥95%, powder
Packaging
5g
Price
$393
Updated
2024/03/01
Alfa Aesar
Product number
J66968
Product name
Aescin, 98%
Packaging
1g
Price
$66.5
Updated
2024/03/01
Alfa Aesar
Product number
J66968
Product name
Aescin, 98%
Packaging
5g
Price
$211.65
Updated
2024/03/01
Sigma-Aldrich
Product number
E1378
Product name
Escin
Purity
≥95%, powder
Packaging
10g
Price
$626
Updated
2024/03/01
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Escin Chemical Properties,Usage,Production

Chemical Properties

saponin mixture

Originator

Aescin,Sinochem

Uses

membrane permeabilizer

Uses

escin is a saponin occurring in the seed of the horse chestnut tree.

Uses

Escin, a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, is used and studied as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent. It may be used to study its pharmacokinetics, safety and efficacy as a chemosensitizer and modulator of NF-κ B cell signaling.

Manufacturing Process

The 1st method of preparation of escin (US Patent No. 3,238,190):
500 g of pulverized horse chestnut seeds were extracted two times for 1 hour with 2.5 L each of aqueous 50% methanol with stirring. The solution was filtered, additional methanol was added thereto to increase the methanol concentration to 65%, and then it was filtered again. The obtained solution containing the extracted saponin had a pH of 5 and was passed through a column of 500 ml (wet volume) of cation exchange resin (Lewatit S-100 of Farben-fabriken Bayer A.G.) which had been treated with 65% methanolic 1% sulfuric acid and then had been washed neutral with 65% methanol. The solution leaving the resin had a pH in the range of about 3 to 4 and was concentrated by distillation to about 4/5 of its original volume. On cooling, crystallization of the escin started and the solution was allowed to stand until the crystallization had been completed. Escin having a melting point of 224- 226°C was obtained in a yield of 2%, calculated on the starting material.
The 2st method of preparations of escin (US Patent No. 3,163,636):
An ethereal solution of 1 kg of cholesterol is added to 100 kg of a 10% aqueous-alcoholic horse extract. The resulting emulsion is stirred at 90°C for 1 hour, while the ether is distilled off. The water insoluble saponin-cholesterol precipitate is centrifuged and washed with cold water until the wash water is colorless. The precipitate is air-dried at room temperature. The resulting dustfine powder is extracted with ether in a Soxhlet apparatus for 10 days. The residue is treated with 20 kg of methanol and the undissolved material is filtered off. The yellowish methanol solution is treated with activated charcoal until it is colorless. The methanol is distilled off in a vacuum, and the residue is dried over phosphorus pentoxide in a vacuum not exceeding 1 mm Hg. The yield of pure sodium escinate obtained thereby is about 0.8 kg (8%).

Therapeutic Function

Antiedemic, Capillary protective

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Flammability and Explosibility

Non flammable

Escin Preparation Products And Raw materials

Raw materials

Preparation Products

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Escin Suppliers

Belgium 1 China 210 China Hong Kong 1 Europe 1 France 2 Germany 3 India 18 Poland 3 South Korea 1 Spain 1 Switzerland 1 United Kingdom 5 United States 26 USA 1 Global 274
Shaanxi Pioneer Biotech Co., Ltd.
Tel
13720616393；029-84385017-8003 13720616393
Fax
029-84385017
Email
sales@pioneerbiotech.com
Country
China
ProdList
778
Advantage
56
Shaanxi Haochen Biotechnology Co., Ltd
Tel
13289221193 13289221193
Email
734859349@qq.com
Country
China
ProdList
45
Advantage
58
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Shenzhen Sungening Bio-Tech Co., Ltd
Tel
+86-0755-89668383
Fax
+86-0755-89594066/4038
Email
sales@sungening.com
Country
China
ProdList
1319
Advantage
65
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2866
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
XI'AN KPC-CN BIOLOGICAL TECHNOLOGY CO.,LTD.
Tel
86-029-85456576
Fax
86-029-85456576-808
Email
daisy_wang@vip.163.com
Country
China
ProdList
292
Advantage
55
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
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View Lastest Price from Escin manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.
Product
Escin; Horse chestnut extract 6805-41-0
Price
US $0.00/KG
Min. Order
1KG
Purity
20%; 40%; 98% UV
Supply Ability
1000KG
Release date
2022-09-21
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Escin Powder 6805-41-0
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-18
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Escin 6805-41-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-12

6805-41-0, EscinRelated Search:

PANAX NOTOGINSENOSIDES Ginseng extract Hecogenin 5-Chlorovaleric acid DL-α-Tocopherol 4-(Diethylamino)salicylaldehyde TRIBULOSIDE Diosgenin Diphenolic acid Grape Seed Extract ISATIDS Yeast extract Pralmorelin Saponin HORSETAIL P.E Escin, monosodium salt Escin IA (Aescin IA) Escin IB(Aescin IB)

  • BETA-AESCIN
  • ESCIN
  • Chestnuts extract
  • AESCIN
  • (2S,3S,4S,5R,6R)-6-[[(3S,4R,4aR,6aR,6bS,8R,8aS,9S,10S,12aR,14aR,14bS)-9-Acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(Z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid
  • a-4700
  • aescusan
  • amorphousaescin
  • escina
  • reparilu
  • Escin(aescin) Chestnuts
  • ESCIN, MIXTURE OF SAPONINS
  • SodiumAescinate97-103%
  • Aescine/Escin20%,95-103%
  • Escigenin, 3-(4-O-β-D-glucopyranosyl-2-O-β-D-
  • hydroxy-2-methylbutyrate,acetate
  • xylopyranosyl-β-D-glucopyranuronoside), 3-
  • 3β-[(4-O-β-D-Galactopyranosyl-2-O-β-D-xylo-hexopyranosyl-β-D-glucopyranuronosyl)oxy]-28-[2-methyl-1-oxo-3-(acetyloxy)butoxy]oleana-12-ene-16α,21α,22β,24-tetraol
  • Escine
  • Sodium Aescinate P.E.
  • Escin,Aescin
  • Escin Synonyms Aescin
  • Horse Chestnut seed extract
  • Aescin,Horse Chestnuts extract
  • 6-[[(4S,6aR,6bS,8aR,14bR)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-(2-methyl-1-oxobut-2-enoxy)-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-
  • Horse Chestnut Extract (Standard)
  • Escin (mixture of natural saponins, Technical Grade)
  • Aescin (Horse Chestnut extract)
  • Escin USP/EP/BP
  • (2S,3S,4S,5R,6R)-6-{[(3S,4S,6aR,6bS,8R,8aR,9R,10R,14aR,14bR)-9-(acetyloxy)-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-{[(2E)-2-methylbut-2-enoyl]oxy}-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl]oxy}-4-hydroxy-3,5-bis({[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})oxane-2-carboxylic acid
  • 044
  • 044-04 [as hydrobromide]
  • UK-116
  • Aescin or escin
  • Aescine,mixture
  • Nano-Liposomal ESCIN
  • Aesculus hippocastanum L.
  • Escin Powder
  • 6805-41-0
  • Polysaccharide
  • Monosaccharides
  • Specialty Synthesis
  • BioChemical
  • Biochemicals and Reagents
  • Carbohydrates
  • Carbohydrate Synthesis
  • Inhibitors
  • Herb extract