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Escin

Product Name
Escin
CAS No.
6805-41-0
Chemical Name
Escin
Synonyms
AESCIN;BETA-AESCIN;escina;Escine;Escin USP/EP/BP;044;ESCIN;a-4700;UK-116;reparilu
CBNumber
CB1728224
Molecular Formula
C55H86O24
Formula Weight
1131.26
MOL File
6805-41-0.mol
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Escin Property

Melting point:
224.5°C
Boiling point:
764.81°C (rough estimate)
Density 
1.1200 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
4°C, protect from light
solubility 
Soluble in methanol.
form 
powder
color 
white
Merck 
13,3730
Stability:
Hygroscopic
CAS DataBase Reference
6805-41-0
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Safety

Hazard Codes 
Xn
Risk Statements 
22-20/22
Safety Statements 
22-24/25
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2
RTECS 
KF6296000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E1378
Product name
Escin
Purity
≥95%, powder
Packaging
1g
Price
$103
Updated
2024/03/01
Sigma-Aldrich
Product number
E1378
Product name
Escin
Purity
≥95%, powder
Packaging
5g
Price
$393
Updated
2024/03/01
Alfa Aesar
Product number
J66968
Product name
Aescin, 98%
Packaging
1g
Price
$66.5
Updated
2024/03/01
Alfa Aesar
Product number
J66968
Product name
Aescin, 98%
Packaging
5g
Price
$211.65
Updated
2024/03/01
Sigma-Aldrich
Product number
E1378
Product name
Escin
Purity
≥95%, powder
Packaging
10g
Price
$626
Updated
2024/03/01
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Escin Chemical Properties,Usage,Production

Chemical Properties

saponin mixture

Originator

Aescin,Sinochem

Uses

membrane permeabilizer

Uses

escin is a saponin occurring in the seed of the horse chestnut tree.

Uses

Escin, a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, is used and studied as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent. It may be used to study its pharmacokinetics, safety and efficacy as a chemosensitizer and modulator of NF-κ B cell signaling.

Manufacturing Process

The 1st method of preparation of escin (US Patent No. 3,238,190):
500 g of pulverized horse chestnut seeds were extracted two times for 1 hour with 2.5 L each of aqueous 50% methanol with stirring. The solution was filtered, additional methanol was added thereto to increase the methanol concentration to 65%, and then it was filtered again. The obtained solution containing the extracted saponin had a pH of 5 and was passed through a column of 500 ml (wet volume) of cation exchange resin (Lewatit S-100 of Farben-fabriken Bayer A.G.) which had been treated with 65% methanolic 1% sulfuric acid and then had been washed neutral with 65% methanol. The solution leaving the resin had a pH in the range of about 3 to 4 and was concentrated by distillation to about 4/5 of its original volume. On cooling, crystallization of the escin started and the solution was allowed to stand until the crystallization had been completed. Escin having a melting point of 224- 226°C was obtained in a yield of 2%, calculated on the starting material.
The 2st method of preparations of escin (US Patent No. 3,163,636):
An ethereal solution of 1 kg of cholesterol is added to 100 kg of a 10% aqueous-alcoholic horse extract. The resulting emulsion is stirred at 90°C for 1 hour, while the ether is distilled off. The water insoluble saponin-cholesterol precipitate is centrifuged and washed with cold water until the wash water is colorless. The precipitate is air-dried at room temperature. The resulting dustfine powder is extracted with ether in a Soxhlet apparatus for 10 days. The residue is treated with 20 kg of methanol and the undissolved material is filtered off. The yellowish methanol solution is treated with activated charcoal until it is colorless. The methanol is distilled off in a vacuum, and the residue is dried over phosphorus pentoxide in a vacuum not exceeding 1 mm Hg. The yield of pure sodium escinate obtained thereby is about 0.8 kg (8%).

Therapeutic Function

Antiedemic, Capillary protective

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Flammability and Explosibility

Non flammable

Escin Preparation Products And Raw materials

Raw materials

Preparation Products

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Escin Suppliers

Belgium 1 China 208 China Hong Kong 1 Europe 1 France 2 Germany 3 India 18 Poland 3 South Korea 1 Spain 1 Switzerland 1 United Kingdom 5 United States 26 USA 1 Global 272
Kleos Pharma
Tel
--
Fax
--
Email
guedj.gregory@kleos-pharma.com
Country
France
ProdList
298
Advantage
58
Unipex
Tel
--
Fax
--
Email
hemical@unipex.com
Country
France
ProdList
267
Advantage
58
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View Lastest Price from Escin manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Escin Powder 6805-41-0
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-18
Changsha Staherb Natural Ingredients Co., Ltd.
Product
Escin; Horse chestnut extract 6805-41-0
Price
US $0.00/KG
Min. Order
1KG
Purity
20%; 40%; 98% UV
Supply Ability
1000KG
Release date
2022-09-21
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Escin 6805-41-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-12

6805-41-0, EscinRelated Search:

PANAX NOTOGINSENOSIDES Ginseng extract Hecogenin 5-Chlorovaleric acid DL-α-Tocopherol 4-(Diethylamino)salicylaldehyde TRIBULOSIDE Diosgenin Diphenolic acid Grape Seed Extract ISATIDS Yeast extract Pralmorelin Saponin HORSETAIL P.E Escin, monosodium salt Escin IA (Aescin IA) Escin IB(Aescin IB)

  • BETA-AESCIN
  • ESCIN
  • Chestnuts extract
  • AESCIN
  • (2S,3S,4S,5R,6R)-6-[[(3S,4R,4aR,6aR,6bS,8R,8aS,9S,10S,12aR,14aR,14bS)-9-Acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(Z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid
  • a-4700
  • aescusan
  • amorphousaescin
  • escina
  • reparilu
  • Escin(aescin) Chestnuts
  • ESCIN, MIXTURE OF SAPONINS
  • SodiumAescinate97-103%
  • Aescine/Escin20%,95-103%
  • Escigenin, 3-(4-O-β-D-glucopyranosyl-2-O-β-D-
  • hydroxy-2-methylbutyrate,acetate
  • xylopyranosyl-β-D-glucopyranuronoside), 3-
  • 3β-[(4-O-β-D-Galactopyranosyl-2-O-β-D-xylo-hexopyranosyl-β-D-glucopyranuronosyl)oxy]-28-[2-methyl-1-oxo-3-(acetyloxy)butoxy]oleana-12-ene-16α,21α,22β,24-tetraol
  • Escine
  • Sodium Aescinate P.E.
  • Escin,Aescin
  • Escin Synonyms Aescin
  • Horse Chestnut seed extract
  • Aescin,Horse Chestnuts extract
  • 6-[[(4S,6aR,6bS,8aR,14bR)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-(2-methyl-1-oxobut-2-enoxy)-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-
  • Horse Chestnut Extract (Standard)
  • Escin (mixture of natural saponins, Technical Grade)
  • Aescin (Horse Chestnut extract)
  • Escin USP/EP/BP
  • (2S,3S,4S,5R,6R)-6-{[(3S,4S,6aR,6bS,8R,8aR,9R,10R,14aR,14bR)-9-(acetyloxy)-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-{[(2E)-2-methylbut-2-enoyl]oxy}-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl]oxy}-4-hydroxy-3,5-bis({[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})oxane-2-carboxylic acid
  • 044
  • 044-04 [as hydrobromide]
  • UK-116
  • Aescin or escin
  • Aescine,mixture
  • Nano-Liposomal ESCIN
  • Aesculus hippocastanum L.
  • Escin Powder
  • 6805-41-0
  • Polysaccharide
  • Monosaccharides
  • Specialty Synthesis
  • BioChemical
  • Biochemicals and Reagents
  • Carbohydrates
  • Carbohydrate Synthesis
  • Inhibitors
  • Herb extract