(S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid

Product Name: (S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid
CAS No.: 154212-61-0
Chemical Name: (S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid
Synonyms: MTV;MTV-III;Ureidovaline;N-[2-Isopropylthiazol-4-ylmethyl(methyl)carbamoyl]-L-valine;N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-L-valine;]-4-thiazoL;-N-[(2-isopropyL;Ritonavir EP IMP A;Ritonavir EP Impurity 22;Ritonavir EP Impurity A(BP Impurity A)
CBNumber: CB9854932
Molecular Formula: C14H23N3O3S
Formula Weight: 313.42
MOL File: 154212-61-0.mol

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(S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid Property

Boiling point:: 532.6±40.0 °C(Predicted)
Density: 1.193
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 4.39±0.10(Predicted)
color: Light Yellow to Beige
InChI: InChI=1S/C14H23N3O3S/c1-8(2)11(13(18)19)16-14(20)17(5)6-10-7-21-12(15-10)9(3)4/h7-9,11H,6H2,1-5H3,(H,16,20)(H,18,19)/t11-/m0/s1
InChIKey: OSQWRZICKAOBFA-NSHDSACASA-N
SMILES: C(O)(=O)[C@H](C(C)C)NC(N(C)CC1=CSC(C(C)C)=N1)=O
CAS DataBase Reference: 154212-61-0(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: M314850
Product name: N-[[N-Methyl-N-[(2-isopropyl]-4-thiazolyl)methyl)amino]carbonyl-L-valineCarboxylicAcid
Packaging: 50mg
Price: $155
Updated: 2021/12/16

Activate Scientific

Product number: AS38794
Product name: N-[2-Isopropylthiazol-4-ylmethyl(methyl)carbamoyl]-L-valine
Purity: 95%
Packaging: 1g
Price: $19
Updated: 2021/12/16

AK Scientific

Product number: S031
Product name: N-[2-Isopropylthiazol-4-ylmethyl(methyl)carbamoyl]-L-valine
Packaging: 5g
Price: $37
Updated: 2021/12/16

AK Scientific

Product number: J99144
Product name: N-[2-Isopropylthiazol-4-ylmethyl(methyl)carbamoyl]-L-valine
Packaging: 10g
Price: $45
Updated: 2021/12/16

Activate Scientific

Product number: AS38794
Product name: N-[2-Isopropylthiazol-4-ylmethyl(methyl)carbamoyl]-L-valine
Purity: 95%
Packaging: 5G
Price: $46
Updated: 2021/12/16

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(S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Oil

Uses

N-[[N-Methyl-N-[(2-isopropyl]-4-thiazolyl)methyl)amino]carbonyl-L-valine Carboxylic Acid (Ritonavir EP Impurity A) is an intermediate in the synthesis of Ritonavir.

Synthesis

154248-99-4

154212-61-0

The general procedure for the synthesis of (S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid from N-((N-methyl-N-((2-isopropylthiazol-4-yl)methyl)amino)formyl)-L-valine methyl ester was as follows: compound 28 was prepared by reference to the method used for the preparation of compound 6 in Scheme 4, except that compound 9 was substituted for compound 4 as the starting material. Compound 28 (0.757 g, 2.31 mmol) was dissolved in THF (9 mL), and a freshly prepared aqueous 1M LiOH solution (4.6 mL, 4.6 mmol) was slowly added at room temperature. After 1.5 h of reaction, 1M HCl aqueous solution (7 mL, 7 mmol) was added to neutralize the reaction solution. Subsequently, the reaction mixture was extracted several times with EtOAc (5 × 15 mL). All organic layers were combined and dried with anhydrous sodium sulfate.

References

[1] Patent: WO2008/10921, 2008, A2. Location in patent: Page/Page column 199-200
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 4, p. 602 - 617
[3] Patent: WO2006/90270, 2006, A1. Location in patent: Page/Page column 10
[4] Patent: US5484801, 1996, A
[5] Patent: US5559158, 1996, A

(S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid Suppliers

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View Lastest Price from (S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: (S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid 154212-61-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-26

Shenzhen Nexcon Pharmatechs Ltd.

Product: (S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid 154212-61-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000
Release date: 2025-04-15

Hebei Chuanghai Biotechnology Co,.LTD

Product: N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-L-valine 154212-61-0
Price: US $10.70/KG
Min. Order: 10KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-20

154212-61-0, (S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acidRelated Search:

Pirimiphos-methyl Valine Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Methyl salicylate L-Valine 2-Aminothiazole-4-acetic acid DL-Norvaline Benzothiazole Kresoxim-methyl 1,1'-Carbonyldiimidazole Methyl acetate METSULFURON METHYL Tribenuron methyl ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate [(1S,3S,4S)-4-Amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-carbamic acid 1,1-dimethylethyl ester Thiophanate-methyl Methyl Ritonavir EP Impurity O

N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)Methyl)aMino)carbonyl)-L-valine (MTV-III)

MTV-III N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)Methyl)aMino)carbonyl)-L-valine

(MTV-III) N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)Methyl)aMino)carbonyl)-L-valin

MTV

L-Valine,N-[[methyl[[2-(1-methylethyl)-4-thiazolyl]methyl]amino]carbonyl]-

N-[2-Isopropylthiazol-4-ylmethyl(methyl)carbamoyl]-L-valine

(s)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid

(S)-2-(3-((2-ISOPROPYLTHIAZOL-4-YL)METHYL)-3-METHYLUREIDO)-3-METHYLBUTANOIC ACID,98%

N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-L-valine

MTV-III

N-[N-[(2-isopropyl-4-thiazole)Methyl]-N-Methyl]car

(2S)-3-Methyl-2-{[Methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]Methyl})carbaMoyl]aMino}butanoic acid

Ritonavir Impurity 1(Ritonavir EP Impurity A)

3-methyl-2-[[[methyl-[(2-propan-2-yl-4-thiazolyl)methyl]amino]-oxomethyl]amino]butanoic acid

(S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid in stock GMP Factory

N-[2-Isopropylthiazol-4-ylmethyl (methyl)-carbamoyl]-L-valine(MTV-III)

Ritonavir EP IMP A

Ureidovaline

Ritonavir EP Impurity A(BP Impurity A)

-N-[(2-isopropyL

N-(N-methyl)-N-((2-Isopropyl-4-Thiazolyl)methyl amine) Carbinol- L- valine

]-4-thiazoL

(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoicaci

(S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acidmethylbutanoic acid

N-[2-ISOPROPYLTHIAZOL-4-YLMETHYL(METHYL)CARBAMOYL]-L-VALINE (MTV III ) [RITONAVIR INTERMEDIATE] / CAS:154212-61-0

(S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid USP/EP/BP

Ritonavir EP Impurity 22

(S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acidQ: What is (S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid Q: What is the CAS Number of (S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid Q: What is the storage condition of (S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid Q: What are the applications of (S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid

(((2-Isopropylthiazol-4-yl)methyl)(methyl)carbamoyl)-L-valine

N-[Methyl(2-isopropyl-4-thiazolylmethyl)amino carbonyl]-L-valine

N-[2-Isopropylthiazol-4-ylmethyl(methyl)carbamoyl]-L-valine (ITVM)

N-[[[(2-Isopropyl-4-Thiazolyl)Methyl](Methyl)Amino]Carbonyl]-L-Valine

N-((N-Methyl-N-((2-isopropyl-4-thiazolyl) methyl) carbonyl)-L-valine

(S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid (Ritonavir Impurity)

(2S)-3-Methyl-2-[[methyl[[2-(1-methylethyl)thiazol-4-yl]methyl]carbamoyl]amino]butanoic Acid

154212-61-0

Amino Acids & Derivatives

Heterocycles

Intermediates

ANTI HIV INT.