((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate

Product Name: ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate
CAS No.: 144163-97-3
Chemical Name: ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate
Synonyms: NCT;Ritonavir middle 2;5-(p-NitrophenoxycarbonyloxyMethyl);Thiazolylmethyl-4-nitrophenylcarbonate;4-Nitrophenyl 5-thiazolylmethyl carbonate;[(5-Thiazol)Methyl]-(4-nitrophenyl)carbonate;((5-Thiazolyl)methyl)-(4-nitrophenyl)carbote;4-Nitrophenyl (thiazol-5-ylMethyl) carbonate;((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate;((5-Isothiazolyl)methyl)-(4-nitrophenyl)carbonate
CBNumber: CB4855282
Molecular Formula: C11H8N2O5S
Formula Weight: 280.26
MOL File: 144163-97-3.mol

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((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate Property

Melting point:: 65-67°C
Boiling point:: 475.3±45.0 °C(Predicted)
Density: 1.485
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: Chloroform, Ethyl Acetate (Slightly)
form: Solid
pka: 1.86±0.10(Predicted)
color: Pale Yellow
InChI: InChI=1S/C11H8N2O5S/c14-11(17-6-10-5-12-7-19-10)18-9-3-1-8(2-4-9)13(15)16/h1-5,7H,6H2
InChIKey: FTEKBGGQRNJIPQ-UHFFFAOYSA-N
SMILES: C(OCC1SC=NC=1)(=O)OC1=CC=C([N+]([O-])=O)C=C1
CAS DataBase Reference: 144163-97-3(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

TRC

Product number: T344300
Product name: Thiazolylmethyl-4-nitrophenylcarbonate
Packaging: 250mg
Price: $95
Updated: 2021/12/16

Usbiological

Product number: 290113
Product name: Thiazolylmethyl-4-nitrophenylcarbonate
Packaging: 10mg
Price: $446
Updated: 2021/12/16

Ark Pharm

Product number: P000124985
Product name: 4-Nitrophenyl (thiazol-5-ylmethyl) carbonate
Purity: 97%
Packaging: 5g
Price: $9
Updated: 2021/12/16

Ark Pharm

Product number: P000124985
Product name: 4-Nitrophenyl (thiazol-5-ylmethyl) carbonate
Purity: 97%
Packaging: 10g
Price: $15
Updated: 2021/12/16

Ark Pharm

Product number: P000124985
Product name: 4-Nitrophenyl (thiazol-5-ylmethyl) carbonate
Purity: 97%
Packaging: 25g
Price: $21
Updated: 2021/12/16

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((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate Chemical Properties,Usage,Production

Chemical Properties

Pale-Yellow Solid

Uses

Retinovir intermediate.

Synthesis

38585-74-9

5070-13-3

144163-97-3

General procedure for the synthesis of ((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate (compound 9) from 5-hydroxymethylthiazole (compound 8, 17 mmol) and bis(p-nitrophenyl)carbonate (compound 7, 19 mmol): compound 7 was added to a dichloromethane (DCM, 40 mL) solution of compound 8, followed by triethylamine (26 mmol) . The reaction mixture was stirred at room temperature for 12 h. After completion of the reaction it was concentrated under reduced pressure. The concentrated mixture was diluted with ethyl acetate (EtOAc) and washed sequentially with saturated aqueous sodium carbonate (Na2CO3) solution, water and brine. After washing, the organic solvent was removed under reduced pressure. The residue was purified by fast column chromatography (silica gel as stationary phase, eluent ratio hexane/ethyl acetate=1/1) to give the final compound 9 (4.7 g).

References

[1] Patent: WO2008/10921, 2008, A2. Location in patent: Page/Page column 188-189
[2] Patent: US2010/256366, 2010, A1. Location in patent: Page/Page column 19
[3] Patent: EP2231628, 2015, B1. Location in patent: Paragraph 0878
[4] Patent: US2018/30043, 2018, A1. Location in patent: Paragraph 0163

((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate Preparation Products And Raw materials

Raw materials

Preparation Products

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((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate Suppliers

Canada 2 China 211 Germany 3 India 14 United Kingdom 1 United States 7 Global 238

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View Lastest Price from ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate 144163-97-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-21

Henan Aochuang Chemical Co.,Ltd.

Product: ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate 144163-97-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-10

Hebei Chuanghai Biotechnology Co,.LTD

Product: ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate 144163-97-3
Price: US $10.70/KG
Min. Order: 10KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-13

144163-97-3, ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonateRelated Search:

Sodium carbonate EC 4.2.1.1 (S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid [(1S,3S,4S)-4-Amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-carbamic acid 1,1-dimethylethyl ester Tris(trimethylsilyl)phosphate Triphosgene Dichloromethylphenylsilane Dimethyl carbonate Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Methyl salicylate Chloromethyl isopropyl carbonate 2-Methyl-4-isothiazolin-3-one Methyltriphenylphosphonium bromide Thiophanate-methyl Calcium carbonate Methyl Thiazole ((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate hydrochloride

5-(p-NitrophenoxycarbonyloxyMethyl)

[(5-Thiazol)Methyl]-(4-nitrophenyl)carbonate

((5-thiazolyl)Methyl)-(4-nitrophenyl)carbonate (SC)

NCT

4-Nitrophenyl (thiazol-5-ylMethyl) carbonate

((5-Thiazolyl)methyl)-(4-nitrophenyl)carbote

carbonic acid 4-nitrophenyl 5-thiazolylmethyl ester

RITONAVIR INTERMEDIATE-A THIOZOLE [CARBONIC ACID-4NITROPHENYL-5-THIAZOLYLMETHYLESTER (NCT)

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate

Thiazolylmethyl-4-nitrophenylcarbonate

carbonic acid [4-nitro-2-(5-thiazolylmethyl)phenyl] ester

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate ( for Antiviral Drugs )

((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate in stock GMP Factory

((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate (NCT)

Ritonavir intermediate/Thiazolylmethyl-4-nitrophenylcarbonate

((5-THIAZOLYL)METHYL)-(4-NITROPHENYL)CARBONATE / RITONAVIR INTERMEDIATE/ CAS:144163-97-3

((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate ISO 9001：2015 REACH

4-Nitrophenyl-5-thiazolylcarbonic acid methyl ester

Ritonavir middle 2

4-Nitrophenyl 5-thiazolylmethyl carbonate

(5-Thiazolyl)methyl-(4-nitrophenyl) carbonate (NPTC)

((5-Isothiazolyl)methyl)-(4-nitrophenyl)carbonate

Carbonic acid 4-nitrophenyl 5-thiazolylmethyl este

144163-97-3

44163-97-3

144163-77-3

Heterocyclic Compounds

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Ritonavir

API intermediates