ChemicalBook > CAS DataBase List > ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate
((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate
- Product Name
- ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate
- CAS No.
- 144163-97-3
- Chemical Name
- ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate
- Synonyms
- NCT;Ritonavir middle 2;5-(p-NitrophenoxycarbonyloxyMethyl);Thiazolylmethyl-4-nitrophenylcarbonate;4-Nitrophenyl 5-thiazolylmethyl carbonate;[(5-Thiazol)Methyl]-(4-nitrophenyl)carbonate;((5-Thiazolyl)methyl)-(4-nitrophenyl)carbote;4-Nitrophenyl (thiazol-5-ylMethyl) carbonate;((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate;((5-Isothiazolyl)methyl)-(4-nitrophenyl)carbonate
- CBNumber
- CB4855282
- Molecular Formula
- C11H8N2O5S
- Formula Weight
- 280.26
- MOL File
- 144163-97-3.mol
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((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate Property
- Melting point:
- 65-67°C
- Boiling point:
- 475.3±45.0 °C(Predicted)
- Density
- 1.485
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- Chloroform, Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 1.86±0.10(Predicted)
- color
- Pale Yellow
- InChI
- InChI=1S/C11H8N2O5S/c14-11(17-6-10-5-12-7-19-10)18-9-3-1-8(2-4-9)13(15)16/h1-5,7H,6H2
- InChIKey
- FTEKBGGQRNJIPQ-UHFFFAOYSA-N
- SMILES
- C(OCC1SC=NC=1)(=O)OC1=CC=C([N+]([O-])=O)C=C1
- CAS DataBase Reference
- 144163-97-3(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
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N-Bromosuccinimide Price
TRC
- Product number
- T344300
- Product name
- Thiazolylmethyl-4-nitrophenylcarbonate
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
Usbiological
- Product number
- 290113
- Product name
- Thiazolylmethyl-4-nitrophenylcarbonate
- Packaging
- 10mg
- Price
- $446
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 184019
- Product name
- Carbonic acid 4-nitrophenyl ester thiazol-5-ylmethyl ester
- Purity
- 95%
- Packaging
- 5g
- Price
- $1568
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM0014955
- Product name
- THIAZOLYLMETHYL-4-NITROPHENYLCARBONATE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $1871.1
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM0014955
- Product name
- THIAZOLYLMETHYL-4-NITROPHENYLCARBONATE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $739.2
- Updated
- 2021/12/16
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((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate Chemical Properties,Usage,Production
Chemical Properties
Pale-Yellow Solid
Uses
Retinovir intermediate.
Synthesis
38585-74-9
5070-13-3
144163-97-3
General procedure for the synthesis of ((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate (compound 9) from 5-hydroxymethylthiazole (compound 8, 17 mmol) and bis(p-nitrophenyl)carbonate (compound 7, 19 mmol): compound 7 was added to a dichloromethane (DCM, 40 mL) solution of compound 8, followed by triethylamine (26 mmol) . The reaction mixture was stirred at room temperature for 12 h. After completion of the reaction it was concentrated under reduced pressure. The concentrated mixture was diluted with ethyl acetate (EtOAc) and washed sequentially with saturated aqueous sodium carbonate (Na2CO3) solution, water and brine. After washing, the organic solvent was removed under reduced pressure. The residue was purified by fast column chromatography (silica gel as stationary phase, eluent ratio hexane/ethyl acetate=1/1) to give the final compound 9 (4.7 g).
References
[1] Patent: WO2008/10921, 2008, A2. Location in patent: Page/Page column 188-189
[2] Patent: US2010/256366, 2010, A1. Location in patent: Page/Page column 19
[3] Patent: EP2231628, 2015, B1. Location in patent: Paragraph 0878
[4] Patent: US2018/30043, 2018, A1. Location in patent: Paragraph 0163
((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate 144163-97-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-21
Henan Aochuang Chemical Co.,Ltd.
- Product
- ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate 144163-97-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10
Hebei Chuanghai Biotechnology Co,.LTD
- Product
- ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate 144163-97-3
- Price
- US $10.70/KG
- Min. Order
- 10KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-13
144163-97-3, ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonateRelated Search:
Sodium carbonate
EC 4.2.1.1
(S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid
[(1S,3S,4S)-4-Amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-carbamic acid 1,1-dimethylethyl ester
Tris(trimethylsilyl)phosphate
Triphosgene
Dichloromethylphenylsilane
Dimethyl carbonate
Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT)
Methyl salicylate
Chloromethyl isopropyl carbonate
2-Methyl-4-isothiazolin-3-one
Methyltriphenylphosphonium bromide
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Calcium carbonate
Methyl
Thiazole
((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate hydrochloride