Butamirate citrate

Product Name: Butamirate citrate
CAS No.: 18109-81-4
Chemical Name: Butamirate citrate
Synonyms: HH-197;Acodeen;Panatus;Sinecod;CoughCut;Sincodin;Sincodix;Sinecond;Sincodeen;Abbott 36581
CBNumber: CB9875076
Molecular Formula: C24H37NO10
Formula Weight: 499.55128
MOL File: 18109-81-4.mol

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Butamirate citrate Property

Melting point:: 66-68°C
storage temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White
InChI: InChI=1S/C18H29NO3.C6H8O7/c1-4-17(16-10-8-7-9-11-16)18(20)22-15-14-21-13-12-19(5-2)6-3;7-3(8)1-6(13,5(11)12)2-4(9)10/h7-11,17H,4-6,12-15H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChIKey: JVKMHUAWFDGPTF-UHFFFAOYSA-N
SMILES: C1(C=CC=CC=1)C(CC)C(=O)OCCOCCN(CC)CC.C(O)(C(=O)O)(CC(=O)O)CC(=O)O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 005097
Product name: Butamirate Citrate
Packaging: 5mg
Price: $418
Updated: 2021/12/16

TRC

Product number: B690025
Product name: ButamirateCitrate
Packaging: 25mg
Price: $460
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB19371
Product name: Butamirate citrate
Packaging: 100g
Price: $500
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB19371
Product name: Butamirate citrate
Packaging: 250g
Price: $600
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007949
Product name: BUTAMIRATE CITRATE
Purity: 95.00%
Packaging: 10MG
Price: $739.2
Updated: 2021/12/16

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Butamirate citrate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Sinecod,Hommel,Switz.,1967

Uses

Anxiolytic, Muscle Relaxant

Uses

Butamirate Citrate is a novel antitussive drug. It is used for the symptomatic treatment of non-productive (dry) cough.

Manufacturing Process

18.2 grams of α-phenylbutyric acid chloride are dissolved in 25 ml of toluene. To this solution, there is slowly added a solution of 16.1 grams of diethylaminoethoxyethanol in 25 ml of toluene, the reaction mixture thereby becoming hot. It is then heated for 8 hr under reflux. The reaction mixture, after cooling, is carefully poured onto 75 grams of ice and made alkaline with dilute ammonia. After thorough shaking of the solution, the toluene layer is removed and washed until neutral with water. The toluene solution is treated with carbon and dried over sodium sulfate. The toluene is distilled off from the filtered solution.
The residue is α-phenylbutyric acid diethylaminoethoxyethyl ester. The basic ester is purified by distillation in a high vacuum. 10 grams of ester are added to a solution of 7 grams of citric acid in 30 ml of warm acetone. After standing for some time, the citrate of the ester crystallizes out. After suction filtration and washing with acetone the ester citrate is recrystallized from acetone. The melting point of the citrate is 75°C.

Therapeutic Function

Antitussive

General Description

Butamirate citrate is a non-opioid antitussive with a central effect on receptors in the brain stem. It has also been reported that it reduces bronchospasm with peripheral effect and has anti-inflammatory and anticholinergic effects. Therefore, it is thought to be effective in cough with both acute and chronic etiology.

Butamirate citrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Butamirate citrate Suppliers

Canada 1 China 51 Czech 1 Germany 2 India 6 Russia 1 South Korea 1 United Kingdom 1 United States 5 Global 69

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

SINO High Goal Chemical Technology Co., Ltd.

Tel: 021-57646680 18306277365
Fax: 2469917557
Email: sunkai@chembiobanksh.com
Country: China
ProdList: 2042
Advantage: 55

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18042
Advantage: 56

Chongqing Xingcan Pharmaceutical Technology Co., Ltd.

Tel: 15523000485
Email: xingcanyaoye@sina.com
Country: China
ProdList: 1686
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9648
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Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
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Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6463
Advantage: 55

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
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Shanghai CR Corporation Limited

Tel: 021-80270511; 4006653949
Fax: QQ: 2136646215
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 10044
Advantage: 58

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View Lastest Price from Butamirate citrate manufacturers

Sense Chemicals (Shanghai) Co., Ltd.

Product: Butamirate Citrate 18109-81-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99% HPLC
Supply Ability: 500kg/year
Release date: 2022-11-09

Sense Chemicals (Shanghai) Co., Ltd.

Product: Butamirate Citrate 18109-81-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99% HPLC
Supply Ability: 500kg/year
Release date: 2022-11-08

Sense Chemicals (Shanghai) Co., Ltd.

Product: Butamirate Citrate 18109-81-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99% HPLC
Supply Ability: 500kg/year
Release date: 2022-11-07

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18109-81-4

C18H29NO3C6H8O7

C24H37NO10

Antitussive

Amines

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals