ChemicalBook > CAS DataBase List > Butamirate citrate
Butamirate citrate
- Product Name
- Butamirate citrate
- CAS No.
- 18109-81-4
- Chemical Name
- Butamirate citrate
- Synonyms
- HH-197;Acodeen;Panatus;Sinecod;CoughCut;Sincodin;Sincodix;Sinecond;Sincodeen;Abbott 36581
- CBNumber
- CB9875076
- Molecular Formula
- C24H37NO10
- Formula Weight
- 499.55128
- MOL File
- 18109-81-4.mol
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Butamirate citrate Property
- Melting point:
- 66-68°C
- storage temp.
- Hygroscopic, Refrigerator, Under Inert Atmosphere
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White
- InChI
- InChI=1S/C18H29NO3.C6H8O7/c1-4-17(16-10-8-7-9-11-16)18(20)22-15-14-21-13-12-19(5-2)6-3;7-3(8)1-6(13,5(11)12)2-4(9)10/h7-11,17H,4-6,12-15H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
- InChIKey
- JVKMHUAWFDGPTF-UHFFFAOYSA-N
- SMILES
- C1(C=CC=CC=1)C(CC)C(=O)OCCOCCN(CC)CC.C(O)(C(=O)O)(CC(=O)O)CC(=O)O
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N-Bromosuccinimide Price
Usbiological
- Product number
- 005097
- Product name
- Butamirate Citrate
- Packaging
- 5mg
- Price
- $418
- Updated
- 2021/12/16
TRC
- Product number
- B690025
- Product name
- ButamirateCitrate
- Packaging
- 25mg
- Price
- $460
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB19371
- Product name
- Butamirate citrate
- Packaging
- 100g
- Price
- $500
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB19371
- Product name
- Butamirate citrate
- Packaging
- 250g
- Price
- $600
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0007949
- Product name
- BUTAMIRATE CITRATE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $739.2
- Updated
- 2021/12/16
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Butamirate citrate Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
Sinecod,Hommel,Switz.,1967
Uses
Anxiolytic, Muscle Relaxant
Uses
Butamirate Citrate is a novel antitussive drug. It is used for the symptomatic treatment of non-productive (dry) cough.
Manufacturing Process
18.2 grams of α-phenylbutyric acid chloride are dissolved in 25 ml of toluene.
To this solution, there is slowly added a solution of 16.1 grams of
diethylaminoethoxyethanol in 25 ml of toluene, the reaction mixture thereby
becoming hot. It is then heated for 8 hr under reflux. The reaction mixture,
after cooling, is carefully poured onto 75 grams of ice and made alkaline with
dilute ammonia. After thorough shaking of the solution, the toluene layer is
removed and washed until neutral with water. The toluene solution is treated
with carbon and dried over sodium sulfate. The toluene is distilled off from the
filtered solution.
The residue is α-phenylbutyric acid diethylaminoethoxyethyl ester. The basic
ester is purified by distillation in a high vacuum. 10 grams of ester are added
to a solution of 7 grams of citric acid in 30 ml of warm acetone. After standing
for some time, the citrate of the ester crystallizes out. After suction filtration and washing with acetone the ester citrate is recrystallized from acetone. The
melting point of the citrate is 75°C.
Therapeutic Function
Antitussive
General Description
Butamirate citrate is a non-opioid antitussive with a central effect on receptors in the brain stem. It has also been reported that it reduces bronchospasm with peripheral effect and has anti-inflammatory and anticholinergic effects. Therefore, it is thought to be effective in cough with both acute and chronic etiology.
Butamirate citrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Butamirate citrate manufacturers
Sense Chemicals (Shanghai) Co., Ltd.
- Product
- Butamirate Citrate 18109-81-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99% HPLC
- Supply Ability
- 500kg/year
- Release date
- 2022-11-09
Sense Chemicals (Shanghai) Co., Ltd.
- Product
- Butamirate Citrate 18109-81-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99% HPLC
- Supply Ability
- 500kg/year
- Release date
- 2022-11-08
Sense Chemicals (Shanghai) Co., Ltd.
- Product
- Butamirate Citrate 18109-81-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99% HPLC
- Supply Ability
- 500kg/year
- Release date
- 2022-11-07