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tofenacin hydrochloride

Product Name
tofenacin hydrochloride
CAS No.
10488-36-5
Chemical Name
tofenacin hydrochloride
Synonyms
Elamol;BS 7331;Tofacine;NSC 169432;NSC 113809;Orphenadrine USP RC C;tofenacin hydrochloride;Tofenacine hydrochloride;N-Desmethylorphenadrine Hydrochlori;Orphenadrine Related Compound C (20 mg)
CBNumber
CB9878350
Molecular Formula
C17H21NO.ClH
Formula Weight
291.82
MOL File
10488-36-5.mol
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tofenacin hydrochloride Property

Melting point:
147-148℃ (ethanol ethyl ether )
solubility 
Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Light Beige
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Safety

HS Code 
2922190900
Toxicity
LD50 in mice (mg/kg): 182 orally, 82 s.c., 58 i.p., 36.5 i.v.; in rats: 72 i.p.; in guinea pigs: 92 s.c. (Funcke)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological
Product number
291072
Product name
Tofenacin Hydrochloride
Packaging
1mg
Price
$460
Updated
2021/12/16
TRC
Product number
T528500
Product name
TofenacinHydrochlorideSalt
Packaging
25mg
Price
$1135
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
48975
Product name
TofenacinHClSalt
Packaging
25mg
Price
$2200
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0076679
Product name
METHYL[2-(2-METHYLBENZHYDRYLOXY)ETHYL]AMINE HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$501.63
Updated
2021/12/16
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tofenacin hydrochloride Chemical Properties,Usage,Production

Originator

Elamol,Brocades,UK,1971

Uses

A metabolite of Orphenadrine (O695300). An antidepressant prodrug. Ondansetron USP Related Compound C.

Manufacturing Process

A mixture of 39.5 grams of 2-methylbenzhydrol, 200 ml of β-chloroethanol and 10 ml of concentrated hydrochloric acid is boiled under reflux for 4 hours. After cooling, the reaction mixture is poured into water and extracted with petroleum ether (boiling range 40° to 60°C). The layers are separated and the ethereal solution dried with sodium sulfate. It is then filtered. The filtrate is concentrated by evaporation of the solvent. The residue is distilled under reduced pressure to give 51.0 grams (yield 98%) of β-chloroethyl-2- methylbenzhydryl ether, boiling at 156° to 158°C/2.5 mm. A mixture of 51 grams of β-chloroethyl-2-methylbenzhydryl ether and 35 grams of methylamine in 140 ml of methanol is heated for 6 hours in a closed vessel at a temperature of 125° to 135°C. After cooling, the reaction mixture is poured into water and extracted with petroleum ether (boiling range 40° to 60°C). The ether layer is separated and washed with a 2 N hydrochloric acid solution. The acidic layer is made alkaline and extracted with ether. The ethereal solution is separated and dried with sodium sulfate. After filtration, the solvent is evaporated and the residue distilled under reduced pressure. There is thus obtained 40 grams (yield 80%) of N-methylaminoethyl-2- methylbenzhydrylether boiling at 139° to 143°C/0.7 mm.
The base is dissolved in anhydrous ether, and an ethereal solution of hydrochloric acid is added to form the hydrochloride of N-methylaminoethyl-2- methylbenzhydryl ether. The salt is crystallized from a mixture of ethanol and ether. Yield is 36 grams (78%); melting point 147° to 148°C.

brand name

Tofenacin is INN and BAN.

Therapeutic Function

Psychostimulant

tofenacin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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tofenacin hydrochloride Suppliers

China 10 India 2 South Korea 1 United Kingdom 1 United States 5 Global 19
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
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United States
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19885
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Alfa Chemistry
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info@Alfa-Chemistry.com
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United States
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NE Scientific
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United States
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5030
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United States Biological
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chemicals@usbio.net
Country
United States
ProdList
6214
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International Laboratory Limited
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Email
admin@intlab.org
Country
United States
ProdList
5356
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10488-36-5, tofenacin hydrochlorideRelated Search:

tofenacin hydrochloride 3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene tofenacin ORPHENADRINE HYDROCHLORIDE

  • tofenacin hydrochloride
  • BS 7331
  • Elamol
  • N-Methyl-2-[(2-methylphenyl)phenylmethoxy]ethanamine hydrochloride
  • NSC 113809
  • NSC 169432
  • Tofacine
  • Tofenacine hydrochloride
  • Orphenadrine USP RC C
  • Orphenadrine Related Compound C (20 mg) (N-methyl-[2-(2-methylbenhydryloxy)ethyl]amine hydrochloride)
  • N-Desmethylorphenadrine Hydrochlori
  • Tofenacin HCl (Orphenadrine USP Related Compound C HCl, N-Desmethyl Orphenadrine HCl)
  • Orphenadrine Impurity 8 (Orphenadrine USP RC C)
  • Orphenadrine Related Compound C (20 mg)
  • Orphenadrine Related Compound C (N-methyl-[2-(2-methylbenzhydryloxy)ethyl]amine hydrochloride) (1479031)
  • Orphenadrine Related Compound C as Hydrochloride
  • Orphenadrine USP Related Compound C as Hydrochloride
  • Orphenadrine Related Compound C (20 mg) (N-methyl-2-[phenyl(o-tolyl)methoxy]ethanamine hydrochloride)
  • 10488-36-5