methysergide
- Product Name
- methysergide
- CAS No.
- 361-37-5
- Chemical Name
- methysergide
- Synonyms
- C07199;UML-491;UML 491;Deseril;Desernyl;Methysergid;methysergide;Methylergometrine maleate EP Impurity G;9,10-Didehydro-N-[(S)-1-(hydroxymethyl)propyl]-1,6-dimethylergoline-8β-carboxamide;Ergoline-8-carboxamide,9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-, (8b)-
- CBNumber
- CB9910759
- Molecular Formula
- C21H27N3O2
- Formula Weight
- 353.46
- MOL File
- 361-37-5.mol
methysergide Property
- Melting point:
- 194-196°
- alpha
- D20 -45° (c = 0.5 in pyridine)
- Boiling point:
- 486.87°C (rough estimate)
- Density
- 1.1377 (rough estimate)
- refractive index
- 1.6300 (estimate)
- storage temp.
- Amber Vial, -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly)
- form
- Solid
- pka
- pKa 6.62± 0.02(H2O,t =24,I<0.01)(Approximate)
- color
- Off-White
- Stability:
- Light Sensitive
Safety
- Hazardous Substances Data
- 361-37-5(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- M329359
- Product name
- Methysergide
- Packaging
- 10mg
- Price
- $485
- Updated
- 2021/12/16
- Product number
- API0009062
- Product name
- METHYSERGIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.01
- Updated
- 2021/12/16
methysergide Chemical Properties,Usage,Production
Originator
Sansert,Sandoz,US,1962
Uses
Methysergide (Methylergonovine EP Impurity G) is a serotonergic receptor antagonist.
Uses
Vasoconstrictor (specific in migraine).
Definition
ChEBI: (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide is an ergoline alkaloid.
Manufacturing Process
As described in US Patent 3,218,324, 0.9 part of potassium are dissolved in 500 parts by volume of liquid ammonia, then oxidized with ferric nitrate to potassium amide, after which 4.85 parts of lysergic acid-1'-hydroxybutylamide-2' are dissolved in the obtained mixture. After 15 minutes there are added to the obtained yellow solution 4.1 parts of methyl iodide in 5 parts by volume of ether, the mixture being allowed to stand for 30 more minutes at -60°C. The liquid ammonia is thereupon evaporated and the dry residue is shaken out between water and chloroform. The mixture of bases which remains after the evaporation of the chloroform is chromatographed on a column of 250 parts of aluminum oxide, the desired 1-methyl-lysergic acid-1'- hydroxy-butylamide-2' being washed into the filtrate with chloroform and chloroform-0.2% ethanol. The 1-methyl-lysergic acid-1'hydroxy-butylamide-2' crystallizes from chloroform in the form of plates which melt at 194° to 196°C. Reaction with maleic acid gives the dimaleate, melting at 187° to 188°C.
Therapeutic Function
Migraine therapy
Clinical Use
Methysergide (Sansert), which is structurally identical to methylergonovine except for the addition of a methyl group to the indole nitrogen, has far less of the uterine stimulatory properties of the other agents and, instead, is used exclusively for treatment of migraine headache as a serotonin antagonist at 5-HT1/5-HT2 receptors.Methysergide is a potent peripheral inhibitor of 5-HT receptors in the blood vessel, which inhibits vessel-wall permeability. Methysergide also inhibits the release of histamine from mast cells and stabilizes platelets against the release of 5-HT, which may be responsible for the onset of the migraine attack. In contrast to its peripheral effects, methysergide appears to be a central 5-HT1 agonist, resulting in alleviation of the central hyperalgesia effect that occurs in patients with migraine.