hydroxocobalamin monohydrochloride

Product Name: hydroxocobalamin monohydrochloride
CAS No.: 59461-30-2
Chemical Name: hydroxocobalamin monohydrochloride
Synonyms: Einecs 261-772-4;Vitamin B12a monohydrochloride;Hydroxocobalain onohydrochloride;hydroxocobalamin monohydrochloride;Vitamin B12a hydrochloride >=96% (UV), >=96% (HPLC);Cyanocobalamin Impurity 13 (Cyanocobalamin EP Impurity H Hydrochloride);Cobinamide hydroxide dihydrogen phosphate (ester), inner salt 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole monohydrochloride;Cobinamide,Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with(5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3), hydrochloride (1:1);Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3), monohydrochloride
CBNumber: CB9927953
Molecular Formula: C62H89ClCoN13O15P
Formula Weight: 1381.83
MOL File: 59461-30-2.mol

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hydroxocobalamin monohydrochloride Property

storage temp.: 2-8°C
solubility: methanol: soluble10mg/mL at 20°C, clear, dark red
form: Solid
color: Red to black

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 95200
Product name: Vitamin B12a hydrochloride
Purity: ≥96% (UV), ≥96% (HPLC)
Packaging: 1g
Price: $199.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1324319
Product name: Hydroxocobalamin chloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 3x150mg
Price: $460
Updated: 2024/03/01

Sigma-Aldrich

Product number: H7126
Product name: Vitamin B12a hydrochloride
Purity: analytical standard
Packaging: 100mg
Price: $108
Updated: 2024/03/01

Sigma-Aldrich

Product number: H7126
Product name: Vitamin B12a hydrochloride
Purity: analytical standard
Packaging: 1g
Price: $198.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 95200
Product name: Vitamin B12a hydrochloride
Purity: ≥96% (UV), ≥96% (HPLC)
Packaging: 250mg
Price: $111
Updated: 2024/03/01

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hydroxocobalamin monohydrochloride Chemical Properties,Usage,Production

Biological Activity

Hydroxocobalamin monohydrochloride (Vitamin B12a monohydrochloride) is an injectable, natural vitamin B12 with a favorable adverse reaction profile that can be used as a dietary supplement for vitamin B12 deficiency, including pernicious anemia.

in vitro

The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide and hydroxocobalamin attenuates vascular responses to NO in vitro .

in vivo

Treatment with hydroxocobalamin before or after giving LPS attenuates LPS-induced hypotension and increases in plasma RNI and enhances LPS-induced urinary excretion of RNI. Hydroxocobalamin (20 mg/kg ip) given to Swiss-Webster mice 30 min before giving LPS (16 mg/kg ip) decreases the 24-hr mortality of LPS from 80 to 50% and the 36- and 96-hr mortality from 100 to 60% (hydroxocobalamin).
More than 60% of the mice administered 35 mg/kg (0.63 mmol/kg) of NaSH (LD90) survive (at 24 h) when hydroxocobalamin (0.25 mmol/kg) was given after NaSH administration whereas less than 15% of the mice survive without hydroxocobalamin. Hydroxocobalamin (50–100 μM) or cobalt (50–100 μM) also preventes hepatocyte cytotoxicity induced by NaSH (500 μM). Furthermore, adding hydroxocobalamin 60 min later than NaSH still shows some protective activity.

hydroxocobalamin monohydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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hydroxocobalamin monohydrochloride Suppliers

China 20 India 1 United States 5 Global 26

MedChemexpress LLC

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TargetMol Chemicals Inc.

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Beijing Aomi Jiade Pharmaceutical Technology Co., Ltd

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Energy Chemical

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59461-30-2, hydroxocobalamin monohydrochlorideRelated Search:

Hydroxocobalamin

Einecs 261-772-4

Cobinamide hydroxide dihydrogen phosphate (ester), inner salt 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole monohydrochloride

hydroxocobalamin monohydrochloride

Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3), monohydrochloride

Cobinamide,Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with(5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3), hydrochloride (1:1)

Vitamin B12a monohydrochloride

Vitamin B12a hydrochloride >=96% (UV), >=96% (HPLC)

Hydroxocobalain onohydrochloride

Cyanocobalamin Impurity 13 (Cyanocobalamin EP Impurity H Hydrochloride)

59461-30-2