Avermectin A1a, 5-O-demethyl-22,23-dihydro-

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Avermectin A1a, 5-O-demethyl-22,23-dihydro-

Product Name: Avermectin A1a, 5-O-demethyl-22,23-dihydro-
CAS No.: 71827-03-7
Chemical Name: Avermectin A1a, 5-O-demethyl-22,23-dihydro-
Synonyms: Ivermectin B1a;IvermectinH2B1a;Ivermectin B1a (>85%);Ivermectin Impurity 3;Dihydroavermectin B1a;22,23-dihydroavermectin B1a in Methanol;5-O-Demethyl-22,23-dihydroavermectin A1a;22,23-Dihydro-5-O-demethylavermectin A1a;Avermectin A1a, 5-O-demethyl-22,23-dihydro-;Ivermectin 2-epimer (Dihydro Avermectin B1a)
CBNumber: CB9928288
Molecular Formula: C48H74O14
Formula Weight: 875.09
MOL File: 71827-03-7.mol

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Avermectin A1a, 5-O-demethyl-22,23-dihydro- Property

Melting point:: 155-157°
Boiling point:: 717.97°C (rough estimate)
Density: 1.0683 (rough estimate)
refractive index: 1.6130 (estimate)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: solid
pka: 12.42±0.70(Predicted)
color: white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18768
Product name: Ivermectin B1a
Purity: ≥95%
Packaging: 5mg
Price: $127
Updated: 2024/03/01

Cayman Chemical

Product number: 18768
Product name: Ivermectin B1a
Purity: ≥95%
Packaging: 25mg
Price: $567
Updated: 2024/03/01

ApexBio Technology

Product number: C3905
Product name: IvermectinB1a
Packaging: 5mg
Price: $138
Updated: 2021/12/16

ChemScene

Product number: CS-0108408
Product name: IvermectinB1a
Purity: ≥99.0%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PST0000756
Product name: B-1-ALPHA-IVERMECTIN COMPONENT
Purity: 95.00%
Packaging: 5MG
Price: $499.44
Updated: 2021/12/16

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Avermectin A1a, 5-O-demethyl-22,23-dihydro- Chemical Properties,Usage,Production

Description

Ivermectin B_1a is the main component (>80%) of the anthelmintic ivermectin, which also contains ivermectin B_1b (<20%; ). It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening and very long-lasting hyperpolarization/depolarization of the neuron/muscle cell, thereby blocking further function (EC₅₀ = 104 nM). Formulations containing ivermectin inhibit replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero/hSLAM cells.

Uses

Ivermectin B1a-D2 is a deuterium labelled analogue of Ivermectin B1a (I940815), which is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.

Definition

ChEBI: A macrocyclic lactone that is avermectin B1a in which the double bond present in the spirocyclic ring system has been reduced to a single bond. It is the major component of ivermectin.

References

[1] j. wolsetnholme and a. t. rogers. glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. parasitology131 suppl, s85-s95 (2005).
[2] s. gaisser, l. kellenberger, a. l. kaja, et al. direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of streptomyces avermitilis atcc31272. organic & biomolecular chemistry 1(16), 2840-2847 (2003).
[3] j. p. arena, k. k. liu, p. s. paress, et al. the mechanism of action of avermectins in caenorhabditis elegans: correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity. journal of parasitology 81, 286-294 (1995).

Avermectin A1a, 5-O-demethyl-22,23-dihydro- Preparation Products And Raw materials

Raw materials

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