bamifylline hydrochloride
- Product Name
- bamifylline hydrochloride
- CAS No.
- 20684-06-4
- Chemical Name
- bamifylline hydrochloride
- Synonyms
- AC-3810;Briofil;BAX2793Z;Trentadil;BAX 2793Z;BAX-2793Z;BAMIFYLLINE HCL;BAMIPHYLLINE HCL;BAMIPHYLLINE HCL (GMP);Bamiphyllinehydrochloride
- CBNumber
- CB9929568
- Molecular Formula
- C20H27N5O3.ClH
- Formula Weight
- 421.926
- MOL File
- 20684-06-4.mol
bamifylline hydrochloride Property
- Melting point:
- 185-186°
Safety
- Toxicity
- LD50 in mice, rats (mg/kg): 246, 1139 orally; 89, 131 i.p.; 67, 65 i.v. (Georges)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
bamifylline hydrochloride Chemical Properties,Usage,Production
Originator
Bamifylline,ZYF Pharm Chemical
Uses
Bronchodilator.
Manufacturing Process
A mixture of 100 kg of 8-benzyltheophilline, 36 L of N-ethylethanolamine, 300 L of 1,2-dichlorethane and 71 kg of sodium carbonate was refluxed for 24 hours. Then 36 L of N-ethylethanolamine was added and the reaction mixture was refluxed. After cooling to the mixture was added the water and hydrochloric acid. The organic phase was extracted with hydrochloric acid. The acidic phase was neutralized with sodium carbonate and the 7-(N-ethyl-N-β- hydroxyethylaminoethyl)-8-benzyltheophilline was extracted with dichloromethane. The solvent was evaporated and the free base of 7-(N-ethyl- N-β-hydroxyethylaminoethyl)-8-benzyltheophilline was dissolved in methanol. Hydrochloride of 7-(N-ethyl-N-β-hydroxyethylaminoethyl)-8-benzyltheophilline was obtained by addition to the solution the hydrochloric acid; yield 81%, melting point 185-186°C.
Therapeutic Function
Bronchodilator, Coronary vasodilator
bamifylline hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from bamifylline hydrochloride manufacturers
- Product
- bamifylline hydrochloride 20684-06-4
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2023-09-11