4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride

Product Name: 4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride
CAS No.: 35941-71-0
Chemical Name: 4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride
Synonyms: Fk 1160;RHC 2592;Solantal;Nsc289337;Corensoul;Nta-194 HCl;Usv 2592 HCl;benzo[d]thiazol-2(3H);Tiaramide hydrochloride;Tiaramide hydrochloride-r
CBNumber: CB9941351
Molecular Formula: C15H19Cl2N3O3S
Formula Weight: 392.30066
MOL File: 35941-71-0.mol

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4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride Property

Melting point:: 159-161°
Water Solubility: Completely soluble in water
form: powder to crystal
color: White to Orange to Green
Merck: 14,9424

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Safety

RTECS: TL7050000
HS Code: 2934.20.8000
Toxicity: LD50 in male mice, rats (mg/kg): 178, 203 i.v.; 298, 540 i.p.; 564, 3600 orally (Watanabe)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T3176
Product name: Tiaramide Hydrochloride
Purity: >98.0%(T)
Packaging: 25mg
Price: $123
Updated: 2024/03/01

TCI Chemical

Product number: T3176
Product name: Tiaramide Hydrochloride
Purity: >98.0%(T)
Packaging: 100mg
Price: $370
Updated: 2024/03/01

TRC

Product number: T445105
Product name: Tiaramide Hydrochloride
Packaging: 1g
Price: $950
Updated: 2021/12/16

AK Scientific

Product number: 6762AL
Product name: Tiaramide Hydrochloride
Packaging: 25mg
Price: $357
Updated: 2021/12/16

Chem-Impex

Product number: 38322
Product name: Tiaramidehydrochloride,98%(AssaybyTitration)
Purity: 98%(AssaybyTitration)
Packaging: 100MG
Price: $740.32
Updated: 2021/12/16

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4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride Chemical Properties,Usage,Production

Originator

Solantal,Fujisawa,Japan,1975

Uses

Tiaramide Hydrochloride is a useful compound for treatment of gastrointestinal disease.

Definition

ChEBI: Tiaramide hydrochloride is a member of benzothiazoles.

Manufacturing Process

A solution of ethyl 5-chloro-2-oxo-3-benzo-thiazolineacetate (4.0 grams) in 1- (2-hydroxyethyl)piperazine is heated at 100°C for 24 hours. After cooling, the resulting mixture is extracted with chloroform. The chloroform extract is washed with water and shaken with 10% hydrochloric acid. The hydrochloric acid layer is washed with chloroform, made alkaline with 10% sodium hydroxide solution and extracted with chloroform. The chloroform extract is washed with water, dried over magnesium sulfate and concentrated. The residual oil (5.5 grams) is allowed to stand to form crystals, which are recrystallized from a mixture of ethyl acetate (40 ml) and ethanol (15 ml) to give 3-[4-(2-hydroxyethyl)-1-piperazinylcarbonylmethyl]-5-chloro-2(3H)- benzothiazolinone (3.2 grams) as colorless crystals, MP 159° to 161°C. The following is an alternate method of preparation: A mixture of 3-(1- piperazinyl)carbonylmethyl-5-chloro-2(3H)-benzothiazolinone (500 mg), anhydrous potassium carbonate (400 mg), 2-hydroxyethyl bromide (300 mg) and anhydrous ethanol (20 ml) is heated while refluxing for 5 hours. The reaction mixture is concentrated under reduced pressure. The residue is extracted with chloroform. The chloroform layer is dried over magnesium sulfate and concentrated. The residue is crystallized from a mixture of ethyl acetate and ethanol to give 3-[4-(2-hydroxyethyl]-1- piperazinylcarbonylmethyl]-5-chloro-2(3H)-benzothiazolinone (370 mg) as crystals, MP 159° to 160°C.

Therapeutic Function

Antiinflammatory

4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride Suppliers

China 22 India 1 Japan 1 United States 7 Global 31

TCI (Shanghai) Development Co., Ltd.

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35941-71-0, 4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochlorideRelated Search:

1-ACETYL-4-(2-HYDROXY-ETHYL)-PIPERAZINE X HCL 4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride 5-CHLORO-2-BENZOTHIAZOLINONE 2-AMINO-1-[4-(2-HYDROXY-ETHYL)-PIPERAZIN-1-YL]-ETHANONE 2 HCL Tiaramide 2-AMINO-1-(4-METHYL-PIPERAZIN-1-YL)-ETHANONE 2 HCL Piperazine, 1-methyl-4-[(methylamino)acetyl]- (9CI)

1-Piperazineethanol, 4-[(5-chloro-2-oxo-3(2H)-benzothiazolyl)acetyl]-, monohydrochloride

4-[(5-Chloro-2-oxo-3-benzothiazolinyl)acetyl]-1-piperazineethanol hydrochloride

Fk 1160

Nsc289337

Nta-194 HCl

Tiaramide hydrochloride-r

Usv 2592 HCl

RHC 2592

5-Chloro-3-(2-(4-(2-hydroxyethyl)piperazin-1-yl)-2-oxoethyl)benzo[d]thiazol-2(3H)-one hydrochloride

5-Chloro-3-(2-(4-(2-hydroxyethyl)

benzo[d]thiazol-2(3H)

Tiaramide hydrochloride (JP14)

Corensoul

Solantal

4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride

Tiaramide hydrochloride

2(3H)-Benzothiazolone,5-chloro-3-[2-[4-(2-hydroxyethyl)-1-piperazinyl]-2-oxoethyl]-, hydrochloride(1:1)

1-Piperazineethanol, 4-[(5-chloro-2-oxo-3(2H)-benzothiazolyl)acetyl]-

5-Chloro-3-[[4-(2-hydroxyethyl)piperazin-1-yl]carbonylmethyl]-2-benzothiazolinone Hydrochloride

35941-71-0

35941-70-0

C15H18ClN3O3SHCl