4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride
- Product Name
- 4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride
- CAS No.
- 35941-71-0
- Chemical Name
- 4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride
- Synonyms
- Fk 1160;RHC 2592;Solantal;Nsc289337;Corensoul;Nta-194 HCl;Usv 2592 HCl;benzo[d]thiazol-2(3H);Tiaramide hydrochloride;Tiaramide hydrochloride-r
- CBNumber
- CB9941351
- Molecular Formula
- C15H19Cl2N3O3S
- Formula Weight
- 392.30066
- MOL File
- 35941-71-0.mol
4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride Property
- Melting point:
- 159-161°
- Water Solubility
- Completely soluble in water
- form
- powder to crystal
- color
- White to Orange to Green
- Merck
- 14,9424
Safety
- RTECS
- TL7050000
- HS Code
- 2934.20.8000
- Toxicity
- LD50 in male mice, rats (mg/kg): 178, 203 i.v.; 298, 540 i.p.; 564, 3600 orally (Watanabe)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P403Store in a well-ventilated place.
N-Bromosuccinimide Price
- Product number
- T3176
- Product name
- Tiaramide Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 25mg
- Price
- $123
- Updated
- 2024/03/01
- Product number
- T3176
- Product name
- Tiaramide Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 100mg
- Price
- $370
- Updated
- 2024/03/01
- Product number
- T445105
- Product name
- Tiaramide Hydrochloride
- Packaging
- 1g
- Price
- $950
- Updated
- 2021/12/16
- Product number
- 6762AL
- Product name
- Tiaramide Hydrochloride
- Packaging
- 25mg
- Price
- $357
- Updated
- 2021/12/16
- Product number
- 38322
- Product name
- Tiaramidehydrochloride,98%(AssaybyTitration)
- Purity
- 98%(AssaybyTitration)
- Packaging
- 100MG
- Price
- $740.32
- Updated
- 2021/12/16
4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride Chemical Properties,Usage,Production
Originator
Solantal,Fujisawa,Japan,1975
Uses
Tiaramide Hydrochloride is a useful compound for treatment of gastrointestinal disease.
Definition
ChEBI: Tiaramide hydrochloride is a member of benzothiazoles.
Manufacturing Process
A solution of ethyl 5-chloro-2-oxo-3-benzo-thiazolineacetate (4.0 grams) in 1- (2-hydroxyethyl)piperazine is heated at 100°C for 24 hours. After cooling, the resulting mixture is extracted with chloroform. The chloroform extract is washed with water and shaken with 10% hydrochloric acid. The hydrochloric acid layer is washed with chloroform, made alkaline with 10% sodium hydroxide solution and extracted with chloroform. The chloroform extract is washed with water, dried over magnesium sulfate and concentrated. The residual oil (5.5 grams) is allowed to stand to form crystals, which are recrystallized from a mixture of ethyl acetate (40 ml) and ethanol (15 ml) to give 3-[4-(2-hydroxyethyl)-1-piperazinylcarbonylmethyl]-5-chloro-2(3H)- benzothiazolinone (3.2 grams) as colorless crystals, MP 159° to 161°C. The following is an alternate method of preparation: A mixture of 3-(1- piperazinyl)carbonylmethyl-5-chloro-2(3H)-benzothiazolinone (500 mg), anhydrous potassium carbonate (400 mg), 2-hydroxyethyl bromide (300 mg) and anhydrous ethanol (20 ml) is heated while refluxing for 5 hours. The reaction mixture is concentrated under reduced pressure. The residue is extracted with chloroform. The chloroform layer is dried over magnesium sulfate and concentrated. The residue is crystallized from a mixture of ethyl acetate and ethanol to give 3-[4-(2-hydroxyethyl]-1- piperazinylcarbonylmethyl]-5-chloro-2(3H)-benzothiazolinone (370 mg) as crystals, MP 159° to 160°C.
Therapeutic Function
Antiinflammatory
4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
4-[(5-chloro-2-oxo-2H-benzothiazol-3-yl)acetyl]piperazine-1-ethanol monohydrochloride Suppliers
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