Methyl alpha-bromo-2-chlorophenylacetate
- Product Name
- Methyl alpha-bromo-2-chlorophenylacetate
- CAS No.
- 85259-19-4
- Chemical Name
- Methyl alpha-bromo-2-chlorophenylacetate
- Synonyms
- -Bromo-2-chlorophenylacetate;Methyl a-Bromo-2-chlorophenylacetate;Methyl a-Bromo-2-chlorobenzeneacetat;Methyl α-Bromo-2-chlorophenylacetate;Methyl a-Bromo-2-chlorobenzeneacetate;Methyl α-Bromo-2-chlorobenzeneacetate;Methylα-Bromo-2-chlorophenylacetate>Methyl alpha-bromo-2-chlorophenylacetate;a-Bromo-2-chlorobenzeneacetic Acid Methyl Ester;alpha bromo 2 chloro phenyl acetic methyl ester
- CBNumber
- CB9947308
- Molecular Formula
- C9H8BrClO2
- Formula Weight
- 263.52
- MOL File
- 85259-19-4.mol
Methyl alpha-bromo-2-chlorophenylacetate Property
- Boiling point:
- 281 °C
- Density
- 1.567
- refractive index
- 1.5630 to 1.5670
- Flash point:
- 124 °C
- storage temp.
- Refrigerator
- solubility
- Dichloromethane, Ether, Ethyl Acetate, Methanol
- form
- Solid
- color
- Light Beige
Safety
- RIDADR
- UN 3265 8/PG II
- HS Code
- 2916.39.7900
- HazardClass
- 8
- PackingGroup
- II
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H290May be corrosive to metals
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P234Keep only in original container.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P390Absorb spillage to prevent material damage.
P405Store locked up.
P406Store in corrosive resistant/… container with a resistant inner liner.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M2175
- Product name
- Methyl α-Bromo-2-chlorophenylacetate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $58
- Updated
- 2025/07/31
- Product number
- M2175
- Product name
- Methyl α-Bromo-2-chlorophenylacetate
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $196
- Updated
- 2025/07/31
- Product number
- M294210
- Product name
- Methyl α-Bromo-2-chlorophenylacetate
- Packaging
- 10g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- W8802
- Product name
- Methylalpha-bromo-2-chlorophenylacetate
- Packaging
- 100g
- Price
- $291
- Updated
- 2021/12/16
- Product number
- 075707
- Product name
- Methyl alpha-bromo-2-chlorophenylacetate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $58
- Updated
- 2021/12/16
Methyl alpha-bromo-2-chlorophenylacetate Chemical Properties,Usage,Production
Chemical Properties
Light-Yellow Oil
Uses
Methyl α-Bromo-2-chlorophenylacetate (cas# 85259-19-4) is a compound useful in organic synthesis.
Synthesis
57486-68-7
85259-19-4
General procedure for the synthesis of α-bromo-2-chlorophenylacetic acid methyl ester from o-chlorophenylacetic acid methyl ester: N-bromosuccinimide (1.04 g, 5.84 mmol) and azobisisobutyronitrile (43 mg) were sequentially added to a stirred solution of methyl 2-chlorophenylacetate (0.86 mL, 5.31 mmol) in dichloromethane (10.2 mL, 159 mmol). The reaction mixture was stirred at 100 °C for 16 h under argon protection. After completion of the reaction, the mixture was cooled to room temperature, diluted with ether and filtered. The filtrate was concentrated under reduced pressure to remove the solvent to give an oily residue containing succinimide (456 mg), which was diluted with heptane and filtered again. Finally, the solvent was removed by distillation under reduced pressure to afford methyl α-bromo-2-chlorophenylacetate (1.38 g, 4.56 mmol) in 86% yield. The product was characterized by 1H NMR (500 MHz, CDCl3): δ 7.69 (dd, J = 7.6, 1.8 Hz, 1H), 7.31 (dd, J = 7.6, 1.7 Hz, 1H), 7.24 (td, J = 7.6, 1.7 Hz, 1H), 7.21 (dd, J = 7.5, 1.8 Hz, 1H), 5.84 (s 1H), 3.74 (s, 3H).
References
[1] Patent: WO2018/149856, 2018, A1. Location in patent: Paragraph 93-94
[2] Patent: WO2018/149853, 2018, A1. Location in patent: Page/Page column 96
[3] Angewandte Chemie - International Edition, 2013, vol. 52, # 16, p. 4440 - 4444
[4] Angew. Chem., 2013, vol. 125, # 16, p. 4536 - 4540,5
[5] Journal of Medicinal Chemistry, 1993, vol. 36, # 23, p. 3738 - 3742
Methyl alpha-bromo-2-chlorophenylacetate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl alpha-bromo-2-chlorophenylacetate manufacturers
- Product
- Methyl alpha-bromo-2-chlorophenylacetate 85259-19-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%HPLC
- Supply Ability
- 10 tons/month
- Release date
- 2020-01-07