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3-Hydroxythiophene-2-carboxylic acid

Product Name
3-Hydroxythiophene-2-carboxylic acid
CAS No.
5118-07-0
Chemical Name
3-Hydroxythiophene-2-carboxylic acid
Synonyms
3-Hydroxy-2-thiophenecarboxylic acid;3-Hydroxythiophene-2-carboxylic acid;2-Thiophenecarboxylic acid, 3-hydroxy-;2-(dihydroxymethylidene)-3-thiophenone;3-Hydroxythiophene-2-carboxylic acid 97%;2-Carboxy-3-hydroxythiophene, 3-Hydroxy-2-thenoic acid;3-Hydroxythiophene-2-carboxylic acid ISO 9001：2015 REACH
CBNumber
CB9956788
Molecular Formula
C5H4O3S
Formula Weight
144.15
MOL File
5118-07-0.mol
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3-Hydroxythiophene-2-carboxylic acid Property

Melting point:
108 °C(Solv: acetone (67-64-1))
Boiling point:
326.4±27.0 °C(Predicted)
Density 
1.603±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
form 
crystalline powder
pka
3.79±0.10(Predicted)
color 
Brown/grey
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Safety

Hazard Codes 
Xi
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
H963570
Product name
3-Hydroxythiophene-2-carboxylicAcid
Packaging
100mg
Price
$150
Updated
2021/12/16
TRC
Product number
H963570
Product name
3-Hydroxythiophene-2-carboxylicAcid
Packaging
500mg
Price
$695
Updated
2021/12/16
SynQuest Laboratories
Product number
6H66-1-X2
Product name
3-Hydroxythiophene-2-carboxylic acid
Purity
97%
Packaging
250mg
Price
$205
Updated
2021/12/16
AK Scientific
Product number
7114AB
Product name
3-Hydroxythiophene-2-carboxylicacid
Packaging
250mg
Price
$236
Updated
2021/12/16
Matrix Scientific
Product number
082513
Product name
3-Hydroxythiophene-2-carboxylic acid
Purity
97%
Packaging
1g
Price
$470
Updated
2021/12/16
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3-Hydroxythiophene-2-carboxylic acid Chemical Properties,Usage,Production

Uses

3-Hydroxythiophene-2-carboxylic acid (cas# 5118-07-0) is a useful research chemical. This compound is useful because furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site.

Synthesis

186588-88-5

5118-07-0

General procedure for the synthesis of 3-hydroxythiophene-2-carboxylic acid from 3-benzyloxythiophene-2-carboxylic acid: a) 3-benzyloxythiophene-2-carboxylic acid (1.0 g) was hydrogenated with 10% palladium-carbon catalyst (1.8 g) in a mixture of ethanol (150 mL) and 2N hydrochloric acid (4.5 mL) for 2 hours at 45 psi hydrogen pressure. Upon completion of the reaction, the mixture was filtered through a layer of diatomaceous earth and the filtrate was concentrated under vacuum to afford 3-hydroxythiophene-2-carboxylic acid (600 mg, 98% yield) as an off-white solid product. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 6.78 (d, 1H), 7.49 (d, 1H). Mass spectrometry (APCI) showed m/z=145 (M+1).LC/MS analysis showed a retention time of 1.15 min.

References

[1] Patent: WO2007/1225, 2007, A1. Location in patent: Page/Page column 16

3-Hydroxythiophene-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Hydroxythiophene-2-carboxylic acid manufacturers

Career Henan Chemical Co
Product
3-Hydroxythiophene-2-carboxylic acid 5118-07-0
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-13

5118-07-0, 3-Hydroxythiophene-2-carboxylic acidRelated Search:

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  • 3-Hydroxythiophene-2-carboxylic acid
  • 3-Hydroxy-2-thiophenecarboxylic acid
  • 2-Carboxy-3-hydroxythiophene, 3-Hydroxy-2-thenoic acid
  • 3-Hydroxythiophene-2-carboxylic acid 97%
  • 2-(dihydroxymethylidene)-3-thiophenone
  • 2-Thiophenecarboxylic acid, 3-hydroxy-
  • 3-Hydroxythiophene-2-carboxylic acid ISO 9001：2015 REACH
  • 5118-07-0
  • C5H4O3S
  • Carboxylic Acids
  • Thiophenes & Benzothiophenes
  • Carboxylic Acids
  • Thiophenes & Benzothiophenes